Results 21 to 30 of about 17,358 (223)
Cancer Cell International, 2022 Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA).
Jingli Cai +6 more
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Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension
Epigenetics, 2023 Idiopathic pulmonary arterial hypertension (IPAH) is a serious and fatal disease. Recently, m6A has been reported to play an important role in the lungs of IPAH patients and experimental pulmonary hypertension models. However, the meaning of m6A mRNAs in
Ting Huang +9 more
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Mining for METTL3 inhibitors to suppress cancer
Nature Structural & Molecular Biology, 2021 The RNA methyltransferase METTL3 catalyzes N6-methyladenosine (m6A) modification of messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute myelogenous leukemia (AML), and promotes cancer cell growth and tumorigenicity. Now, a selective small molecule inhibitor of METTL3 shows significant antileukemic effects in preclinical
Jiazhi Li, Richard I. Gregory
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Circadian rhythms and post-transcriptional regulation in higher plants [PDF]
, 2015 The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés +1 more
core +6 more sources
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation [PDF]
Open Biology, 2017 Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining myogenic transcription factors such as MyoD. However, the mechanism of how MyoD expression is maintained in proliferative progenitor cells has not been ...
Kensuke Kudou +8 more
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Frontiers in Pharmacology, 2022 Epigenetic regulation plays a critical role in the development, progression, and treatment of tumors. The most common chemical modification of mRNA, called m6A, is essential for controlling mRNA stability, splicing, and translation.
Fangfang Ge +7 more
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METTL3 regulates breast cancer-associated alternative splicing switches
Oncogene, 2022 ABSTRACTAlternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play major roles in the development of different pathologies, including breast cancer.N6-methyladenosine (m6A), the most abundant internal modification of eukaryotic ...
Cyrinne Achour +4 more
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Mettl3 promotes oxLDL‐mediated inflammation through activating STAT1 signaling [PDF]
Journal of Clinical Laboratory Analysis, 2021 Abstract Background Atherosclerosis (AS) is the main cause of cerebrovascular diseases, and macrophages act important roles during the AS pathological process through regulating inflammation. Modification of the novel N(6)‐methyladenine (m6A) RNA is reported to be associated with AS, but its ...
Zhenwei Li +4 more
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Analysis of METTL3 and METTL14 in hepatocellular carcinoma
Aging, 2020 N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of messenger RNAs (mRNAs) and catalyzed by a multicomponent methyltransferase complex (MTC), among which methyltransferase-like 3 (METTL3) and METTL14 are two core molecules. However, METTL3 and METTL14 play opposite regulatory roles in hepatocellular carcinoma (HCC).
Liu, Xiangxiang +13 more
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iScience, 2023 Summary: METTL3 is the major writer of N6-Methyladenosine (m6A) and has been associated with controversial roles in cancer. This is best illustrated in urothelial carcinoma of the bladder (UCB), where METTL3 was described to have both oncogenic and tumor-
Jonas Koch +13 more
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