Results 21 to 30 of about 16,538 (257)

Exon2 Mettl3 KO mESCs express altered METTL3 proteins while exon4 Mettl3 KO mESCs do not.

, 2022
(A) Exon2 Mettl3 KO mESCs express a novel protein that is immunoreactive to several anti-METTL3 antibodies. We found that exon2 Mettl3 KO mESCs express new proteins that are reactive to an anti-METTL3 pAb.
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

7SK methylation by METTL3 promotes transcriptional activity [PDF]

Science Advances, 2023
A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcriptional elongation by sequestering the cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positive ...
Marcelo Perez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón   +9 more
openaire   +3 more sources

METTL3-mediated m⁶A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis

, 2023
Doxorubicin (DOX) resistance in breast cancer (BC) poses a huge challenge for the therapeutic effect on BC. Lnc KCNQ1OT1 play crucial roles in chemotherapy resistance.
Zhiyang Zhou (6252770), Yuan Yang (151457), Feiyu Chen (7479809), Yukun Cao (287252), Shouman Wang (3842485)   +4 more
core   +1 more source

METTL3 regulates heterochromatin in mouse embryonic stem cells [PDF]

, 2021
METTL3 (methyltransferase-like 3) mediates the N6-methyladenosine (m6A) methylation of mRNA, which affects the stability of mRNA and its translation into protein1.
Wen, J, Li, J, Ma, H, Shen, H, Xu, W, Wu, F, Shi, YG, Wang, J, Shi, Yang, Wang, L, He, C, Tan, L, Diao, J, Rong, B   +13 more
core   +1 more source

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

Cancer Cell International, 2022
Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA).
Jingli Cai, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding, Hai Hu   +6 more
doaj   +1 more source

METTL3/m6A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma

Frontiers in Pharmacology, 2022
Epigenetic regulation plays a critical role in the development, progression, and treatment of tumors. The most common chemical modification of mRNA, called m6A, is essential for controlling mRNA stability, splicing, and translation.
Fangfang Ge, Fangfang Ge, Zhenyu Li, Zhenyu Li, Jiaru Hu, Youguang Pu, Fangfang Zhao, Lingsuo Kong   +7 more
doaj   +1 more source

Previously described Mettl3 KO mESC lines express shorter isoforms of Mettl3.

, 2022
(A) Mettl3 KO mESCs from two groups have different m6A levels. To reconfirm the m6A levels using quantitative methods, we performed mass spectrometry to estimate the m6A in mRNA.
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma

Journal of Translational Medicine, 2022
Background As an important N6-methyladenosine (m6A) regulator, abnormal expression of methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers.
Dawei Zhu, Yingting Liu, Junjun Chen, Qi Wang, Yuan Li, Yulan Zhu, Jun Feng, Jingting Jiang   +7 more
doaj   +1 more source

METTL3-mediated m⁶A modification is required for cerebellar development [PDF]

, 2018
N6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs and plays important roles in various biological processes. The formation of m6A is catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as
Wei Li (7081), Hai-Lin Wang, Guan-Shen Cui (5349773), Chen-Xin Wang (5349779), Ang Li (110963), Bao-Fa Sun (257565), Xiu-Jie Wang, Xin-Xin Zhang (359043), Wei-Min Tong (119899), Li-Yuan Jiang (4632328), Yun-Gui Yang (119905), Ying Yang (24175), Wei Li, Chen-Xin Wang, Qi Zhou (7408), Xiu-Jie Wang (4830), Wei-Min Tong, Xiuying Liu (137554), Kai Xu (122914), Hai-Lin Wang (4476319), Guan-Shen Cui, Yun-Gui Yang, Kai Xu, Wei-Yi Lai, Ang Li, Qi Zhou, Gui-Bin Jiang (806959), Xiuying Liu, Bao-Fa Sun, Li-Yuan Jiang, Meng Wang (124646), Meng Wang, Xin-Xin Zhang, Gui-Bin Jiang, Wei-Yi Lai (5349776), Ying Yang   +35 more
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Cry2-mCh-METTL3 interaction with EGFP-METTL3/14.

, 2022
(A) Co-immunoprecipitation assay with HEK293T coexpressing Cry2-mCh-METTL3 and EGFP-tagged METTL3 or METTL14. IB, immunoblot; IP, immunoprecipitation; METTL3, methyltransferase-like 3; METTL14, methyltransferase-like 14; WCL, whole cell lysate; WTAP ...
Vivian Hoang (12072856), Xuemei Zhang (89768), Kenneth S. Kosik (7435415), Dasol Han (7435397), Andrew P. Longhini (11007554), Maxwell Z. Wilson (9930238)   +5 more
core   +1 more source