Results 11 to 20 of about 13,391 (192)
The catalytic mechanism of the RNA methyltransferase METTL3
eLife, 2023 The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N6-methyladenosine (m6A) modifications on messenger RNA (mRNA) in humans. METTL3-14 plays key roles in various biological processes through its methyltransferase (MTase) activity.
Corbeski, Ivan +11 more
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Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension
Epigenetics, 2023 Idiopathic pulmonary arterial hypertension (IPAH) is a serious and fatal disease. Recently, m6A has been reported to play an important role in the lungs of IPAH patients and experimental pulmonary hypertension models. However, the meaning of m6A mRNAs in
Ting Huang +9 more
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Mining for METTL3 inhibitors to suppress cancer
Nature Structural & Molecular Biology, 2021 The RNA methyltransferase METTL3 catalyzes N6-methyladenosine (m6A) modification of messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute myelogenous leukemia (AML), and promotes cancer cell growth and tumorigenicity. Now, a selective small molecule inhibitor of METTL3 shows significant antileukemic effects in preclinical
Jiazhi Li, Richard I. Gregory
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The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation [PDF]
Open Biology, 2017 Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining myogenic transcription factors such as MyoD. However, the mechanism of how MyoD expression is maintained in proliferative progenitor cells has not been ...
Kensuke Kudou +8 more
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Analysis of METTL3 and METTL14 in hepatocellular carcinoma
Aging, 2020 N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of messenger RNAs (mRNAs) and catalyzed by a multicomponent methyltransferase complex (MTC), among which methyltransferase-like 3 (METTL3) and METTL14 are two core molecules. However, METTL3 and METTL14 play opposite regulatory roles in hepatocellular carcinoma (HCC).
Liu, Xiangxiang +13 more
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Frontiers in Pharmacology, 2022 Epigenetic regulation plays a critical role in the development, progression, and treatment of tumors. The most common chemical modification of mRNA, called m6A, is essential for controlling mRNA stability, splicing, and translation.
Fangfang Ge +7 more
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International Journal of Immunopathology and Pharmacology, 2023 Objectives METTL3 as an m 6 A methyltransferase acts in diverse malignancies including gastric cancer (GC). We aimed to reveal the underlying mechanisms by which METTL3 contributes to gastric carcinogenesis.
Guo Ji, Xiu Wang, Hao Xi
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Roles of METTL3 in cancer: mechanisms and therapeutic targeting [PDF]
Journal of Hematology & Oncology, 2020 AbstractN6-methyladenosine (m6A) is the most abundant mRNA modification and is catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is the sole catalytic subunit. Accumulating evidence in recent years reveals that METTL3 plays key roles in a variety of cancer types, either dependent or independent on its m6A RNA ...
Chengwu Zeng +3 more
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Journal of Translational Medicine, 2022 Background As an important N6-methyladenosine (m6A) regulator, abnormal expression of methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers.
Dawei Zhu +7 more
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METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis
Journal of Experimental & Clinical Cancer Research, 2022 Background Colorectal carcinoma (CRC) is the third most common cancer and second most common cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) and methyltransferase-like 3 (METTL3) play key roles in cancer ...
Jiashu Pan +11 more
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