METTL3 regulates WTAP protein homeostasis [PDF]
Cell Death & Disease, 2018 AbstractThe Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Sorci, Melissa +8 more
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The catalytic mechanism of the RNA methyltransferase METTL3 [PDF]
eLife, 2023 The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N6-methyladenosine (m6A) modifications on messenger RNA (mRNA) in humans. METTL3-14 plays key roles in various biological processes through its methyltransferase (MTase) activity.
Corbeski, Ivan +11 more
core +8 more sources
Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder [PDF]
iScience, 2023 Summary: METTL3 is the major writer of N6-Methyladenosine (m6A) and has been associated with controversial roles in cancer. This is best illustrated in urothelial carcinoma of the bladder (UCB), where METTL3 was described to have both oncogenic and tumor-
Jonas Koch +13 more
doaj +2 more sources
METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes [PDF]
ChemMedChem, 2021 Abstract The methylase METTL3 is the writer enzyme of the N 6 ‐methyladenosine (m 6 A) modification of RNA. Using a structure‐based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM,
Moroz-Omori, Elena V +9 more
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Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation [PDF]
Cell Reports, 2023 Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear.
Tao Wei +15 more
doaj +2 more sources
Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE [PDF]
Molecular MedicineObjective METTL3, an m6A methyltransferase, enhances germinal center responses. This study explores its role in lupus B cells and its impact on B-cell activation.
Yiying Yang +9 more
doaj +2 more sources
METTL3 as a potential therapeutic target in gastric cancer [PDF]
Frontiers in OncologyGastric cancer (GC) is one of the leading causes of cancer-related death worldwide. N6-methyladenosine (m6A) modification is the most prominent epigenetic modification of eukaryotic mRNAs, and methyltransferase-like 3 (METTL3), a core component of the methyltransferase complex, catalyzes m6A modification.
Zhefei Yu, Yang Yang
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METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2 [PDF]
Scientific ReportsN6-methyladenosine (m6A) is the most prevalent modification found in eukaryotic RNA and played a significant role in various cancers. However, the mechanism by which m6A modification influences cervical cancer (CC) tumorigenesis remains unclear ...
Yilin Guo +6 more
doaj +2 more sources
Exon2 Mettl3 KO mESCs express altered METTL3 proteins while exon4 Mettl3 KO mESCs do not. [PDF]
, 2022 (A) Exon2 Mettl3 KO mESCs express a novel protein that is immunoreactive to several anti-METTL3 antibodies. We found that exon2 Mettl3 KO mESCs express new proteins that are reactive to an anti-METTL3 pAb.
Hui Xian Poh (13118985) +3 more
core +1 more source
METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis [PDF]
, 2023 Doxorubicin (DOX) resistance in breast cancer (BC) poses a huge challenge for the therapeutic effect on BC. Lnc KCNQ1OT1 play crucial roles in chemotherapy resistance.
Zhiyang Zhou (6252770) +4 more
core +1 more source