Results 11 to 20 of about 17,358 (223)

Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA

PLoS Biology, 2022
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transcripts encoding proteins that have roles in cell development, differentiation, and other pathways. METTL3 is the major methyltransferase that catalyzes the
Hui Xian Poh, Aashiq H. Mirza, Brian F. Pickering, Samie R. Jaffrey   +3 more
doaj   +5 more sources

METTL3 regulates WTAP protein homeostasis [PDF]

Cell Death & Disease, 2018
The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina, Cruciani, Sonia, Fatica, Alessandro, Fazi, Francesco, Ginistrelli, Lavinia Ceci, Ianniello, Zaira, Larivera, Simone, Marchioni, Marcella, Sorci, Melissa   +8 more
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Regulation of Methylase METTL3 on Fat Deposition

Diabetes, Metabolic Syndrome and Obesity, 2021
Gang Luo, Jialing Chen, Zhanjun Ren College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People’s Republic of ChinaCorrespondence: Zhanjun RenCollege of Animal Science and Technology, Northwest A&F University ...
Luo G, Chen J, Ren Z
doaj   +4 more sources

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia [PDF]

Nature, 2021
N6-methyladenosine (m6A) is an abundant internal RNA modification1,2 that is catalysed predominantly by the METTL3-METTL14 methyltransferase complex3,4.
Eliza Yankova, Wesley Blackaby, Etienne De Braekeleer   +2 more
exaly   +3 more sources

METTL3–m6A–STAT1/NF-κB axis: a key switch for the immunosuppressive capacity of mesenchymal stem cells [PDF]

Cellular & Molecular Biology Letters
Background Owing to their immunosuppressive nature, mesenchymal stem cells (MSCs)—a type of multipotent stem cell—hold considerable promise for therapeutic applications.
Keke Tang, Hong Han, Ruizheng Sun, Yi Xu, Shengdi Zhang, Chen Lai, Yu Peng   +6 more
doaj   +2 more sources

The catalytic mechanism of the RNA methyltransferase METTL3 [PDF]

eLife, 2023
The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N$^{6}$-methyladenosine (m$^{6}$A) modifications on messenger RNA (mRNA) in humans.
Bedi, Rajiv Kumar, Braud, Emmanuelle, Caflisch, Amedeo, Coelho, Dylan, Corbeski, Ivan, Cui, Qiang, Deng, Jiahua, Ethève-Quelquejeu, Mélanie, Huang, Danzhi, Iannazzo, Laura, Li, Yaozong, Vargas-Rosales, Pablo Andrés   +11 more
core   +5 more sources

TBK1-METTL3 Axis Facilitates Antiviral Immunity [PDF]

SSRN Electronic Journal, 2021
mRNA m6A modification is heavily involved in modulation of immune responses. However, its function in antiviral immunity is controversial, and how immune responses regulate m6A modification remains elusive. We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m6A methyltransferase METTL3 at serine 67. The phosphorylated METTL3
Jingxuan, Chen, Xuemei, Wei, Xiao, Wang, Tong, Liu, Yingchi, Zhao, Luoying, Chen, Yujie, Luo, Hongqiang, Du, Yunfei, Li, Tongtong, Liu, Lili, Cao, Zhe, Zhou, Zeming, Zhang, Ling, Liang, Lu, Li, Xuhui, Yan, Xuehui, Zhang, Xuliang, Deng, Guang, Yang, Ping, Yin, Jianlei, Hao, Zhinan, Yin, Fuping, You   +22 more
openaire   +2 more sources

7SK methylation by METTL3 promotes transcriptional activity [PDF]

Science Advances, 2023
A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcriptional elongation by sequestering the cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positive ...
Marcelo Perez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón   +9 more
openaire   +3 more sources

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

eLife, 2023
N 6 -methyladenosine (m 6 A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to ...
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
openaire   +3 more sources

METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
doaj   +1 more source