Results 11 to 20 of about 16,538 (257)
A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression
eLife, 2023 N6-methyladenosine (m6A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to breast tumorigenesis, but the underlying ...
Zirui Zhou +12 more
core +4 more sources
METTL3 regulates WTAP protein homeostasis [PDF]
Cell Death & Disease, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Ginistrelli, Lavinia Ceci +8 more
core +5 more sources
The catalytic mechanism of the RNA methyltransferase METTL3 [PDF]
eLife, 2023 The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N6-methyladenosine (m6A) modifications on messenger RNA (mRNA) in humans.
Yaozong Li +11 more
core +7 more sources
Regulation of Methylase METTL3 on Fat Deposition
Diabetes, Metabolic Syndrome and Obesity, 2021 Gang Luo, Jialing Chen, Zhanjun Ren College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People’s Republic of ChinaCorrespondence: Zhanjun RenCollege of Animal Science and Technology, Northwest A&F University ...
Luo G, Chen J, Ren Z
doaj +4 more sources
Archives of Medical ScienceIntroduction Intervertebral disc degeneration (IVDD) is a significant contributor to the development of discogenic low back pain and impairment. Apoptosis and degradation of the extracellular matrix (ECM) have also been reported to be major factors in ...
Bo Ran, Ziqing Yang, Mengzhao Li
doaj +2 more sources
The Emerging Role of METTL3 in Lung Diseases
International Journal of Molecular SciencesN6-methyladenosine (m6A) represents the most abundant and tightly controlled modification within eukaryotic mRNA, critically influencing RNA metabolism and function. The m6A methyltransferase Like-3 (METTL3), responsible for the complex’s catalytic
Ying Liu +5 more
core +3 more sources
iScience, 2023 Summary: METTL3 is the major writer of N6-Methyladenosine (m6A) and has been associated with controversial roles in cancer. This is best illustrated in urothelial carcinoma of the bladder (UCB), where METTL3 was described to have both oncogenic and tumor-
Jonas Koch +13 more
doaj +2 more sources
METTL3 as a potential therapeutic target in gastric cancer [PDF]
Frontiers in OncologyGastric cancer (GC) is one of the leading causes of cancer-related death worldwide. N6-methyladenosine (m6A) modification is the most prominent epigenetic modification of eukaryotic mRNAs, and methyltransferase-like 3 (METTL3), a core component of the ...
Zhefei Yu, Yang Yang
core +4 more sources
Scientific ReportsN6-methyladenosine (m6A) is the most prevalent modification found in eukaryotic RNA and played a significant role in various cancers. However, the mechanism by which m6A modification influences cervical cancer (CC) tumorigenesis remains unclear ...
Yilin Guo +6 more
doaj +2 more sources
TBK1-METTL3 Axis Facilitates Antiviral Immunity [PDF]
SSRN Electronic Journal, 2021 mRNA m6A modification is heavily involved in modulation of immune responses. However, its function in antiviral immunity is controversial, and how immune responses regulate m6A modification remains elusive. We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m6A methyltransferase METTL3 at serine 67. The phosphorylated METTL3
Jingxuan, Chen +22 more
openaire +2 more sources