Results 41 to 50 of about 16,538 (257)

Depletion of METTL3 leads to slower proliferation in MEFs.

, 2022
(A) Mettl3 conditional knockout MEFs do not express METTL3 protein. To confirm that Mettl3 is the sole m6A writer in cell lines other than mESCs, we produced a tamoxifen-inducible Mettl3 conditional knockout MEF cell line.
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

Roles of METTL3 in cancer: mechanisms and therapeutic targeting [PDF]

Journal of Hematology & Oncology, 2020
AbstractN6-methyladenosine (m6A) is the most abundant mRNA modification and is catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is the sole catalytic subunit. Accumulating evidence in recent years reveals that METTL3 plays key roles in a variety of cancer types, either dependent or independent on its m6A RNA ...
Chengwu Zeng, Wanxu Huang, Yangqiu Li, Hengyou Weng   +3 more
openaire   +3 more sources

METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis

Epigenetics, 2023
Doxorubicin (DOX) resistance in breast cancer (BC) poses a huge challenge for the therapeutic effect on BC. Lnc KCNQ1OT1 play crucial roles in chemotherapy resistance.
Zhiyang Zhou, Yukun Cao, Yuan Yang, Shouman Wang, Feiyu Chen   +4 more
doaj   +1 more source

LLPS of Cry2-mCherry-METTL3.

, 2022
(A) (Left) Representative confocal images of HEK293T expressing Cry2-mCherry constructs before and after (blue dots) blue light (488 nm) stimulation. (Right) Demixing index at 300 seconds of blue light stimulation was quantified by CV across the nucleus.
Vivian Hoang (12072856), Xuemei Zhang (89768), Kenneth S. Kosik (7435415), Dasol Han (7435397), Andrew P. Longhini (11007554), Maxwell Z. Wilson (9930238)   +5 more
core   +1 more source

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer [PDF]

, 2022
Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing ...
Persson, Jenny L., Jennie N. Jeyapalan, Robinson, Brian D., Nigel P. Mongan, Rutland, Catrin S., Nathan Archer, Emad A. Rakha, Jenny L. Persson, Mansour Alsaleem, Veronika M. Metzler, Toss, Michael S., Bodi, Zsuzsanna, Davis, Melissa B., Kristian B. Laursen, Lorraine J. Gudas, Alsaleem, Mansour, Archer, Nathan, Metzler, Veronika M., Jeyapalan, Jennie N., Zsuzsanna Bodi, Catrin S. Rutland, Atara Ntekim, Harris, Anna E., Corinne L. Woodcock, Michael S. Toss, Woodcock, Corinne L., Haigh, Daisy B., Rupert G. Fray, Madhusudan, Srinivasan, Srinivasan Madhusudan, Rakha, Emad A., Mongan, Nigel P., Daisy B. Haigh, Jennifer Lothion-Roy, Gudas, Lorraine J., Fray, Rupert G., Francesca Khani, Brian D. Robinson, Lothion-Roy, Jennifer, Ntekim, Atara, Anna E. Harris, Laursen, Kristian B., Khani, Francesca, Melissa B. Davis   +43 more
core   +1 more source

Cry2-mCh-METTL3 undergoes light-inducible LLPS.

, 2022
(A) Phase separation of METTL3 and pSC35 in SH-SY5Y cells. (Left) Endogenous METTL3 (green) and the nuclear speckle marker pSC35 (red) were stained using ICC. A layered and punctate distribution of METTL3 was observed surrounding central pSC35 staining. (
Vivian Hoang (12072856), Xuemei Zhang (89768), Kenneth S. Kosik (7435415), Dasol Han (7435397), Andrew P. Longhini (11007554), Maxwell Z. Wilson (9930238)   +5 more
core   +1 more source

Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics

Open Life Sciences, 2023
N6-methyladenosine (m6A) is a representative of RNA methylation modification, which plays a critical role in the epigenetic modification process of regulating human diseases.
Liu Hanqi, Huang Yanqing, Lu Shanshan, Yuan Didi, Liu Junwen   +4 more
doaj   +1 more source

Conditional METTL3 knockouts can be used to study m⁶A when stable METTL3 knockouts are not viable.

, 2022
(A) Most cell lines are dependent on METTL3 for growth. Mouse studies previously indicated that Mettl3 is an essential gene for early embryonic survival [5], so we wanted to know which cell lines are dependent on METTL3.
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

M6A Methyltransferase METTL3 Modulates Traumatic Brain Injury by Targeting Ferroptosis

Frontiers in Bioscience-Landmark
Background: Traumatic brain injury (TBI) is a disease caused by external forces that damage brain structure and function. After TBI, iron accumulation and reactive oxygen species (ROS) increase lipid peroxidation, promoting ferroptosis.
Fei Qin, Fan Li, Wenxiao Zhao, Suqin Zhang, Jiang Shen, Xinyu Yang   +5 more
doaj   +1 more source

Upregulation of METTL3 Expression Predicts Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Cancer Management and Research, 2020
Tian-Liang Xia,* Shu-Mei Yan,* Li Yuan, Mu-Sheng Zeng State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China*These authors ...
Xia TL, Yan SM, Yuan L, Zeng MS
doaj