Results 41 to 50 of about 17,358 (223)
implications for health and disease [PDF]
, 2014 Many aspects of human physiology and behavior display rhythmicity with a period of approximately 24 h. Rhythmic changes are controlled by an endogenous time keeper, the circadian clock, and include sleep-wake cycles, physical and mental performance ...
An, Shejuan +9 more
core +2 more sources
The RNA Methyltransferase METTL3 Promotes Oncogene Translation [PDF]
Cancer Discovery, 2016 Abstract METTL3 enhances translation independent of methyltransferase activity and methyl reader proteins.
openaire +2 more sources
METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes
ChemMedChem, 2021 Abstract The methylase METTL3 is the writer enzyme of the N 6 ‐methyladenosine (m 6 A) modification of RNA. Using a structure‐based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM,
Moroz-Omori, Elena V +9 more
openaire +2 more sources
Experimental Hematology & Oncology, 2022 Background N6-methyladenosine (m6A) RNA methylation and its methyltransferase METTL3 have been widely reported to be involved in different cancers by regulating RNA metabolism and function.
Yu-qing Guo +7 more
doaj +1 more source
METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer
Frontiers in Oncology, 2022 The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC.
Nuofan Wang +7 more
doaj +1 more source
陆军军医大学学报Objective To investigate the molecular mechanism by which methytransferase like3 (METTL3) cooperates with insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) to regulate HBV replication through N6-methyladenosine (m6A) modifications.
YU Ling, ZHANG Zili, ZENG Rong
doaj +1 more source
Cell Death Discovery, 2021 Ovarian cancer is a common gynecological malignant tumor with a high mortality rate and poor prognosis. There is inadequate knowledge of the molecular mechanisms underlying ovarian cancer.
Xuehan Bi +7 more
doaj +1 more source
Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]
, 2015 Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan +5 more
core +3 more sources
Cancer Cell International, 2022 Background N6-methyladenosine (m6A) has emerged as a significant regulator of the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear.
Yiming Xu +6 more
doaj +1 more source
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]
, 2017 Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven) +6 more
core +4 more sources