Results 41 to 50 of about 15,062 (245)

METTL3 knockout in U2OS cells also appears to be incomplete. [PDF]

, 2022
(A) METTL3 KO U2OS cells have persistent m6A. METTL3 KO U2OS cells have been reported to have 60% the levels of m6A found in control U2OS cells [24]. We reconfirmed this with mass spectrometry measurements of m6A, which showed that METTL3 KO U2OS cells ...
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

Analysis of METTL3 and METTL14 in hepatocellular carcinoma

Aging, 2020
N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of messenger RNAs (mRNAs) and catalyzed by a multicomponent methyltransferase complex (MTC), among which methyltransferase-like 3 (METTL3) and METTL14 are two core molecules. However, METTL3 and METTL14 play opposite regulatory roles in hepatocellular carcinoma (HCC).
Liu, Xiangxiang, Qin, Jian, Gao, Tianyi, Li, Chenmeng, Chen, Xiaoxiang, Zeng, Kaixuan, Xu, Mu, He, Bangshun, Pan, Bei, Xu, Xueni, Pan, Yuqin, Sun, Huiling, Xu, Tao, Wang, Shukui   +13 more
openaire   +2 more sources

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer [PDF]

, 2022
Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing ...
Persson, Jenny L., Jennie N. Jeyapalan, Robinson, Brian D., Nigel P. Mongan, Rutland, Catrin S., Nathan Archer, Emad A. Rakha, Jenny L. Persson, Mansour Alsaleem, Veronika M. Metzler, Toss, Michael S., Bodi, Zsuzsanna, Davis, Melissa B., Kristian B. Laursen, Lorraine J. Gudas, Alsaleem, Mansour, Archer, Nathan, Metzler, Veronika M., Jeyapalan, Jennie N., Zsuzsanna Bodi, Catrin S. Rutland, Atara Ntekim, Harris, Anna E., Corinne L. Woodcock, Michael S. Toss, Woodcock, Corinne L., Haigh, Daisy B., Rupert G. Fray, Madhusudan, Srinivasan, Srinivasan Madhusudan, Rakha, Emad A., Mongan, Nigel P., Daisy B. Haigh, Jennifer Lothion-Roy, Gudas, Lorraine J., Fray, Rupert G., Francesca Khani, Brian D. Robinson, Lothion-Roy, Jennifer, Ntekim, Atara, Anna E. Harris, Laursen, Kristian B., Khani, Francesca, Melissa B. Davis   +43 more
core   +2 more sources

METTL3-deficient macrophage enhances the phagocytosis of Aβ. [PDF]

, 2023
(A) Representative fluorescence micrographs and quantitative analysis of brains from Aβ-induced mice transferred with WT and KO BM. (B) Representative fluorescence micrographs and quantitative analysis of brain from Aβ-induced mice transferred with WT ...
Xiang Zhang (19800), Zhuan Ju (14755548), Xiaofang Zhang (181594), Wenjie Zuo (11050641), Jiadi Li (12914183), Huilong Yin (14755545), Yidi Wang (3079407), Xiaochen Ding (6841085), Yingran Peng (14755551), Rui Zhang (13940), Minhua Zheng (232421), Angang Yang (250347)   +11 more
core   +1 more source

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages. [PDF]

, 2023
Recent efforts in understanding the epitranscriptome have shown that a diverse set of modifications to RNA represent a new pervasive mechanism of gene regulation, with roles in stem cell homeostasis and disease.

core   +5 more sources

METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis

Journal of Experimental & Clinical Cancer Research, 2022
Background Colorectal carcinoma (CRC) is the third most common cancer and second most common cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) and methyltransferase-like 3 (METTL3) play key roles in cancer ...
Jiashu Pan, Feng Liu, Xiaoli Xiao, Ruohui Xu, Liang Dai, Mingzhe Zhu, Hanchen Xu, Yangxian Xu, Aiguang Zhao, Wenjun Zhou, Yanqi Dang, Guang Ji   +11 more
doaj   +1 more source

Roles of METTL3 in cancer: mechanisms and therapeutic targeting [PDF]

Journal of Hematology & Oncology, 2020
AbstractN6-methyladenosine (m6A) is the most abundant mRNA modification and is catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is the sole catalytic subunit. Accumulating evidence in recent years reveals that METTL3 plays key roles in a variety of cancer types, either dependent or independent on its m6A RNA ...
Chengwu Zeng, Wanxu Huang, Yangqiu Li, Hengyou Weng   +3 more
openaire   +3 more sources

Ligand binding states determine METTL3 phase transition. [PDF]

, 2022
(A) Representative images (left) and quantitation (right) representing demixing of Cry2-mCh-METTL3 D395A (catalytic motif, SAM binding pocket) or N549A/Q550A (SAM binding pocket) mutants after (blue dot) blue light stimulation. Scale bar = 10 μm.
Vivian Hoang (12072856), Xuemei Zhang (89768), Kenneth S. Kosik (7435415), Dasol Han (7435397), Andrew P. Longhini (11007554), Maxwell Z. Wilson (9930238)   +5 more
core   +1 more source

METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression

Experimental Hematology & Oncology, 2022
Background N6-methyladenosine (m6A) RNA methylation and its methyltransferase METTL3 have been widely reported to be involved in different cancers by regulating RNA metabolism and function.
Yu-qing Guo, Qiang Wang, Jun-guo Wang, Ya-jun Gu, Pan-pan Song, Shou-yu Wang, Xiao-yun Qian, Xia Gao   +7 more
doaj   +1 more source

METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246

Cell Death Discovery, 2021
Ovarian cancer is a common gynecological malignant tumor with a high mortality rate and poor prognosis. There is inadequate knowledge of the molecular mechanisms underlying ovarian cancer.
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang   +7 more
doaj   +1 more source