Results 41 to 50 of about 13,391 (192)

O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer

Molecular Medicine
Background Pancreatic cancer is highly lethal, and METTL3 plays a crucial role in the regulation of m6A. However, the therapeutic potential of METTL3 in pancreatic cancer is unclear.
Qiuhong Wang, Dong Wei, Chunman Li, Xiawei Yang, Kun Su, Tao Wang, Renchao Zou, Lianmin Wang, Dongyun Cun, Bo Tang, Tao Wu   +10 more
doaj   +1 more source

Research Progress on Methyltransferase-like Protein 3 in Progression of Aerobic Glycolysis in Gastrointestinal Tumors

Zhongliu Fangzhi Yanjiu
Metabolic reprogramming is one of the significant characteristics of malignant tumor development. It provides the tumor with sufficient energy and materials. During the process by which tumor cells acquire metabolic reprogramming, epigenetic changes play
Deyuan MA, Na WANG, Huiqiang WANG, Quanlin GUAN   +3 more
doaj   +1 more source

Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder

iScience, 2023
Summary: METTL3 is the major writer of N6-Methyladenosine (m6A) and has been associated with controversial roles in cancer. This is best illustrated in urothelial carcinoma of the bladder (UCB), where METTL3 was described to have both oncogenic and tumor-
Jonas Koch, Manuel Neuberger, Martina Schmidt-Dengler, Jinyun Xu, Vitor Coutinho Carneiro, Jörg Ellinger, Maximilian C. Kriegmair, Philipp Nuhn, Philipp Erben, Maurice Stephan Michel, Mark Helm, Manuel Rodríguez-Paredes, Malin Nientiedt, Frank Lyko   +13 more
doaj   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics

Open Life Sciences, 2023
N6-methyladenosine (m6A) is a representative of RNA methylation modification, which plays a critical role in the epigenetic modification process of regulating human diseases.
Liu Hanqi, Huang Yanqing, Lu Shanshan, Yuan Didi, Liu Junwen   +4 more
doaj   +1 more source

METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m6A Dependent Manner

Frontiers in Oncology, 2021
Acquired chemoresistance is a major limiting factor in the clinical treatment of glioblastoma (GBM). However, the mechanism by which GBM acquires therapeutic resistance remains unclear.
Jia Shi, Jia Shi, Gang Chen, Xuchen Dong, Haoran Li, Suwen Li, Shan Cheng, Yongdong Li, Liping Wang, Jiaqi Yuan, Zhiyuan Qian, Jun Dong   +11 more
doaj   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4

Frontiers in Bioscience-Landmark
Background: Osteosarcoma cells are prone to metastasis, and the mechanism of N6-methyladenosine (m6A) methylation modification in this process is still unclear.
Xi-song Huo, Dan Lu, Da-gui Chen, Min Ye, Xiao-wei Wang, Fu-sheng Shang   +5 more
doaj   +1 more source

Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

Cell Reports, 2023
Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear.
Tao Wei, Jin Li, Jian Zhang, Qi Zhang, Xiaoyu Liu, Qi Chen, Liang Wen, Ke Ma, Wen Chen, Jianhui Zhao, Cheng Zhang, Jinyan Huang, Yali Xie, Hao Qin, Danfeng Qian, Tingbo Liang   +15 more
doaj   +1 more source

The Emerging Role of METTL3 in Lung Diseases

International Journal of Molecular Sciences
N6-methyladenosine (m6A) represents the most abundant and tightly controlled modification within eukaryotic mRNA, critically influencing RNA metabolism and function. The m6A methyltransferase Like-3 (METTL3), responsible for the complex’s catalytic function, has emerged as a central epitranscriptomic regulator governing mRNA stability, alternative ...
Yishu Dong, Ying Liu, David Marciano, Adel Nefzi, Stephen M. Black, Ting Wang   +5 more
openaire   +2 more sources