Results 1 to 10 of about 475,417 (315)

Adenosine as an Active Ingredient in Topical Preparations Against Hair Loss: A Systematic Review and Meta-Analysis of Published Clinical Trials

Biomolecules
Research results suggest the potential of topical adenosine as a hair-promoting agent. The aim of this study was to examine the available clinical evidence of the efficacy of topical adenosine products in hair loss.
Ewelina Szendzielorz, Radoslaw Spiewak
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Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science
Although the intestinal clock (the circadian timing system in the gastrointestinal tract) is known to direct a wide variety of diurnal nutrients and metabolites, its role in the functioning of extra‐intestinal tissues such as the brain remains elusive ...
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
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CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue

Frontiers in Immunology
Next to white and brown adipocytes present in white and brown adipose tissue (WAT, BAT), vascular endothelial cells, tissue-resident macrophages and other immune cells have important roles in maintaining adipose tissue homeostasis but also contribute to ...
Michelle Y. Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren   +6 more
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Purinergic Signalling: Therapeutic Developments

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
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Deletion of murine slc29a4 modifies vascular responses to adenosine and 5‐hydroxytryptamine in a sexually dimorphic manner

Physiological Reports, 2020
Equilibrative nucleoside transporter 4 (ENT4), encoded by SLC29A4, mediates the flux of both 5‐hydroxytryptamine (5‐HT) and adenosine across cell membranes.
Ran Wei, Stephen L. Gust, David Tandio, Alexia Maheux, Khanh H. Nguyen, Joanne Wang, Stephane Bourque, Frances Plane, James R. Hammond   +8 more
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Clinical Implications of Unmasking Dormant Conduction After Circumferential Pulmonary Vein Isolation in Atrial Fibrillation Using Adenosine: A Systematic Review and Meta-Analysis

Frontiers in Physiology, 2019
Purpose: Circumferential pulmonary vein isolation (CPVI) is a routine ablation strategy of atrial fibrillation (AF). The adenosine test can be used to unmask dormant conduction (DC) of pulmonary veins after CPVI, thereby demonstrating possible pulmonary ...
Cheng Chen, Daobo Li, Jeffery Ho, Tong Liu, Xintao Li, Zhao Wang, Yajuan Lin, Fuquan Zou, Gary Tse, Gary Tse, Yunlong Xia   +10 more
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Design and Characterization of Elastic Artificial Skin Containing Adenosine-Loaded Solid Lipid Nanoparticles for Treating Wrinkles

Pharmaceutics, 2020
Adenosine (AD), which is used for treating wrinkles, exhibits poor skin permeation. The aim of the present study was to develop a cross-linked silicone-based cellulose elastomer as an elastic artificial skin for the treatment of skin wrinkles, a ...
Sooho Yeo, Sukkyun Jung, Heui Kyoung Cho, Young Ho Kim, Gi Hwan Kim, Dohyun Kim, Byoung Hyen Ko, Jaehwi Lee   +7 more
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Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores

Frontiers in Pharmacology, 2017
Duchenne muscular dystrophy (DMD) is an X-linked disorder that leads to cardiac and skeletal myopathy. The complex immune activation in boys with DMD is incompletely understood.
Jonathan H. Soslow, Larry W. Markham, Larry W. Markham, W. Bryan Burnette, Cristi L. Galindo, Igor Feoktistov, Frank J. Raucci, Bruce M. Damon, Douglas B. Sawyer, Douglas B. Sawyer, Sergey Ryzhov   +10 more
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Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells

Cells, 2020
Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs).
Sebastián Alarcón, María de los Ángeles Toro, Carolina Villarreal, Rómulo Melo, Rodrigo Fernández, Angel Ayuso Sacido, Daniel Uribe, Rody San Martín, Claudia Quezada   +8 more
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Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex

Frontiers in Pharmacology, 2018
Caffeine is the most widely used psychoactive drug, bolstering attention and normalizing mood and cognition, all functions involving cerebral cortical circuits.
Amber Kerkhofs, Amber Kerkhofs, Ana C. Xavier, Beatriz S. da Silva, Paula M. Canas, Sander Idema, Johannes C. Baayen, Samira G. Ferreira, Rodrigo A. Cunha, Rodrigo A. Cunha, Huibert D. Mansvelder   +10 more
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