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Special Issue: Adenosine Receptors [PDF]
Molecules, 2017 Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. [...]
Francisco Ciruela, Eddy Sotelo
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Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation [PDF]
Biomedicines, 2022 Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the ...
Baptiste Maille +12 more
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A metabolic immune checkpoint: adenosine in tumor microenvironment [PDF]
Frontiers in Immunology, 2016 Within tumors, some areas are less oxygenated than others. Since their home ground is under chronic hypoxia, tumor cells adapt to this condition by activating aerobic glycolysis; however, this hypoxic environment is very harsh for incoming immune cells ...
Akio eOhta
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Gene expression pattern of adenosine receptors in lung tumors [PDF]
Cancer Reports, 2023 Background Adenosine, a purine nucleoside, plays an important function in the pathogenesis of cancer through interaction with the cell surface G protein‐coupled adenosine receptors.
Elnaz Asgharkhah +3 more
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Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro [PDF]
Reproductive Biology and EndocrinologyBackground Sperm capacitation is a prerequisite for natural or in vitro fertilization. After capacitation, sperm become hyperactivated and undergo an acrosome reaction, which helps them penetrate the oocyte.
Lijun Shan +8 more
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Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K +6 more
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Antitumoral Action of Resveratrol Through Adenosinergic Signaling in C6 Glioma Cells
Frontiers in Neuroscience, 2021 Gliomas are the most common and aggressive primary tumors in the central nervous system. The nucleoside adenosine is considered to be one major constituent within the tumor microenvironment. The adenosine level mainly depends on two enzymatic activities:
Alejandro Sánchez-Melgar +3 more
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Adenosine A2A and A3 Receptors as Targets for the Treatment of Hypertensive-Diabetic Nephropathy
Biomedicines, 2020 Diabetic nephropathy (DN) and hypertension are prime causes for end-stage renal disease (ESRD) that often coexist in patients, but are seldom studied in combination.
Daniela Patinha +9 more
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The Journal of Headache and Pain, 2022 Background Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist ...
Janu Thuraiaiyah +3 more
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Annual Review of Physiology, 1992 Our knowledge of A1 and A2ARs has grown dramatically since they were first defined by Burnstock. With the recent purification of the A1AR and the cDNA cloning of the A2AR, an even more rapid expansion of information regarding their structure, function, and regulation should now ensue.
M E, Olah, G L, Stiles
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