Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation [PDF]
Biomedicines, 2022 Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the ...
Baptiste Maille +12 more
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Gene expression pattern of adenosine receptors in lung tumors [PDF]
Cancer Reports, 2023 Background Adenosine, a purine nucleoside, plays an important function in the pathogenesis of cancer through interaction with the cell surface G protein‐coupled adenosine receptors.
Elnaz Asgharkhah +3 more
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Special Issue: Adenosine Receptors [PDF]
Molecules, 2017 Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. [...]
Francisco Ciruela, Eddy Sotelo
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Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro [PDF]
Reproductive Biology and EndocrinologyBackground Sperm capacitation is a prerequisite for natural or in vitro fertilization. After capacitation, sperm become hyperactivated and undergo an acrosome reaction, which helps them penetrate the oocyte.
Lijun Shan +8 more
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Antitumoral Action of Resveratrol Through Adenosinergic Signaling in C6 Glioma Cells
Frontiers in Neuroscience, 2021 Gliomas are the most common and aggressive primary tumors in the central nervous system. The nucleoside adenosine is considered to be one major constituent within the tumor microenvironment. The adenosine level mainly depends on two enzymatic activities:
Alejandro Sánchez-Melgar +3 more
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The Journal of Headache and Pain, 2022 Background Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist ...
Janu Thuraiaiyah +3 more
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Adenosine A2A and A3 Receptors as Targets for the Treatment of Hypertensive-Diabetic Nephropathy
Biomedicines, 2020 Diabetic nephropathy (DN) and hypertension are prime causes for end-stage renal disease (ESRD) that often coexist in patients, but are seldom studied in combination.
Daniela Patinha +9 more
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Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. [PDF]
PLoS ONE, 2015 The "regulators of g-protein signalling" (RGS) comprise a large family of proteins that limit by virtue of their GTPase accelerating protein domain the signal transduction of G-protein coupled receptors.
Till Nicolas Eusemann +4 more
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The immunomodulatory function of adenosine in sepsis
Frontiers in Immunology, 2022 Sepsis is an unsolved clinical condition with a substantial mortality rate in the hospital. Despite decades of research, no effective treatments for sepsis exists. The role of adenosine in the pathogenesis of sepsis is discussed in this paper.
Teng Zhang, Li Yu-Jing, Tao Ma
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The A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1. [PDF]
PLoS ONE, 2018 It was previously shown that the estrogen-receptor negative breast cancer cell line MBA-MD-231 expresses high levels of A2B adenosine receptors as the sole adenosine receptor subtype.
Marthe Koussémou +2 more
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