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Purine and purinergic receptors [PDF]
Brain and Neuroscience Advances, 2018 Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a
Geoffrey Burnstock
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Purine and purinergic receptors in health and disease
MedComm, 2023 Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Nianzhi Chen
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Purinergic Receptors in Ocular Inflammation [PDF]
Mediators of Inflammation, 2014 Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease.
Ana Guzman-Aranguez +3 more
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The Role of Microglial Purinergic Receptors in Pain Signaling
Molecules, 2022 Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Kazuhide Inoue +2 more
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Purinergic Regulation of Neutrophil Function
Frontiers in Immunology, 2018 Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen, Chen Deyu
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Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?
Frontiers in Allergy, 2021 Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airways. Consequently,
Rebecca J. Thompson +3 more
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Purinergic Receptors in Dendritic Cells
Journal of Inflammation ResearchMiaomiao Wang,1 Xiaoxiao Zhao,1 Shuai Hou,1 Zhongbo Wu,2 Hai-yan Yin1 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Brain Disease Research Center, Tongren People’s ...
Wang M, Zhao X, Hou S, Wu Z, Yin HY
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Purinergic signaling in the male reproductive tract
Frontiers in Endocrinology, 2022 Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin +4 more
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Purinergic Signaling in Liver Pathophysiology
Frontiers in Endocrinology, 2021 Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
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Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
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