Results 1 to 10 of about 29,008 (251)
Glial Purinergic Signaling in Neurodegeneration [PDF]
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
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The Role of Microglial Purinergic Receptors in Pain Signaling
Molecules, 2022 Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Hidetoshi Tozaki-Saitoh +2 more
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Purinergic Signaling and Related Biomarkers in Depression [PDF]
Brain Sciences, 2020 It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter ...
Francesco Bartoli +3 more
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Purinergic signaling in schistosomal infection
Biomedical Journal, 2016 Human schistosomiasis is a chronic inflammatory disease caused by blood fluke worms belonging to the genus Schistosoma. Health metrics indicate that the disease is related to an elevated number of years lost-to-disability and years lost-to-life ...
Claudia Lucia Martins Silva
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Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases
Frontiers in Physiology, 2022 Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue, adenosine, all have the capacity to modulate cellular signaling pathways.
Erika Y. Faraoni +4 more
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Purinergic signaling: Diverse effects and therapeutic potential in cancer [PDF]
Frontiers in Oncology, 2023 Regardless of improved biological insights and therapeutic advances, cancer is consuming multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and physiological parameters as its hallmarks.
Jasmeet Kaur, Sanchit Dora
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Purinergic signaling in infection and autoimmune disease
Biomedical Journal, 2016 Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites.
Luiz Eduardo Baggio Savio +1 more
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Purinergic Signaling in the Hallmarks of Cancer
Cells, 2020 Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic ...
Mauricio DIAZ-MUÑOZ +1 more
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Purinergic Signaling in Ovarian Carcinoma [PDF]
Advanced Pharmaceutical BulletinOvarian carcinoma (OC) is the most lethal gynecological cancer worldwide. Around 95% of patients exhibit recurrence five years after treatment; 80% experience recurrence within 18 months after first-line treatment, and progression-free survival rates ...
Angélica Sofía Martínez-Ramírez +4 more
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Purinergic signaling: A gatekeeper of blood-brain barrier permeation
Frontiers in Pharmacology, 2023 This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Yuemei Wang +6 more
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