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The Role of Microglial Purinergic Receptors in Pain Signaling
Molecules, 2022 Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Hidetoshi Tozaki-Saitoh +2 more
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Purinergic Signaling and Related Biomarkers in Depression [PDF]
Brain Sciences, 2020 It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter ...
Francesco Bartoli +3 more
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In Memoriam Geoffrey Burnstock: Creator of Purinergic Signaling [PDF]
Function, 2020 Geoff Burnstock (1929–2020) discovered purinergic signaling in a fastidious research that started in early 1960 and culminated in a concept of purinergic nerves in 1972.
Alexei Verkhratsky +4 more
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Glial Purinergic Signaling in Neurodegeneration
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
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Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases
Frontiers in Physiology, 2022 Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue, adenosine, all have the capacity to modulate cellular signaling pathways.
Erika Y. Faraoni +4 more
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Cardiomyocytes HIPK2 regulates myocardial inflammation and heart function through purinergic signaling [PDF]
Cell Communication and SignalingPurinergic signaling is critical to myocardial inflammation and function. However, the underlying mechanisms are not well defined. Herein, we identified a protein kinase, homeodomain-interacting protein kinase 2 (HIPK2), as a novel regulator of ...
Sultan Tousif +15 more
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Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction [PDF]
Frontiers in GastroenterologyThe gastrointestinal (GI) tract contains a highly integrated network composed of the enteric nervous system (ENS), epithelial cells, resident immune populations, and intestinal microbiota. Communication among these components is essential for maintaining
Eduardo E. Valdez-Morales +4 more
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Purinergic signaling: A gatekeeper of blood-brain barrier permeation
Frontiers in Pharmacology, 2023 This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Yuemei Wang +6 more
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Extracellular Vesicles and Purinergic Signaling in Alzheimer’s Disease—Joining Forces for Novel Therapeutic Approach [PDF]
Brain SciencesNeurodegenerative diseases, including Alzheimer’s disease (AD), are a global problem affecting millions of people. Thanks to years of research and huge efforts, it has been possible to discover the pathophysiological changes accompanying Alzheimer’s ...
Julita Lewandowska +2 more
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Frontiers in Molecular Neuroscience, 2022 Trigeminal ganglion (TG) is the first station of sensory pathways in the orofacial region. The TG neurons communicate with satellite glial cells (SGCs), macrophages and other cells forming a functional unit that is responsible for processing of orofacial
Shilin Jia +10 more
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