Pathogens, 2023 CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73 pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect.
Ibrahim M Sayed +2 more
exaly +3 more sources
CD39+CD8+ T cell infiltration is associated with clinical outcomes of subsequent immunotherapy in advanced EGFR-mutant non-small cell lung cancer [PDF]
Therapeutic Advances in Medical OncologyBackground: Immunotherapy has demonstrated limited efficacy in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), often due to an immunosuppressive tumor microenvironment (TME).
Wanjun Lu +9 more
doaj +2 more sources
BLIMP-1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses. [PDF]
Immunol Cell BiolThis study found that BLIMP‐1 is highly expressed in activated effector/memory human regulatory T cells, especially CD39+ Tregs, where it is associated with increased IL‐10 production and a conserved phenotype across blood and lung tissues during immune responses such as SARS‐CoV‐2 infection.
Phetsouphanh C +10 more
europepmc +2 more sources
Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report [PDF]
Iranian Journal of Immunology, 2022 Background: Impaired renal function is considered as a significant risk factor for cardiovascular events in chronic kidney disease patients. Several immunosuppressive drugs are used in these patients, which necessitates to minimize the drug-related side ...
Yaghoub Mollaei-Kandelous +7 more
doaj +1 more source
Indian Journal of Dermatology, 2023 Objectives: Peripheral blood immune cell profiling of atopic dermatitis patients before and after treatment by single-cell RNA sequencing technique has not been reported.
Xiao-Guang Gu +6 more
doaj +1 more source
Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct
OncoImmunology, 2022 Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li +10 more
doaj +1 more source
Frontiers in Immunology, 2021 Acute respiratory distress syndrome (ARDS) is characterized by an uncontrollable cytokine storm, which is associated with high mortality due to lack of effective treatment.
Cen Chen +19 more
doaj +1 more source
CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes. [PDF]
PLoS ONE, 2018 The ectoenzymes CD39 and CD73 degrade extracellular ATP to adenosine. ATP is released by stressed or damaged cells and provides pro-inflammatory signals to immune cells through P2 receptors.
Friederike Raczkowski +9 more
doaj +1 more source
Human soluble CD39 displays substrate inhibition in a substrate-specific manner
Scientific Reports, 2023 CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD1) metabolizes extracellular ATP and ADP to AMP. AMP is subsequently metabolized by CD79 to adenosine. CD39 activity is therefore a key regulator of purinergic signalling in cancer, thrombosis,
Venkat M. K. Vadlamani +4 more
doaj +1 more source
Cell Death and Disease, 2023 While ectonucleotidase CD39 is a cancer therapeutic target in clinical trials, its direct effect on T-cell differentiation in human non-small-cell lung cancer (NSCLC) remains unclear.
Ying Wang +8 more
doaj +1 more source