Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. [PDF]
PLoS Neglected Tropical Diseases, 2013 HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP.
Fabio E Leal +10 more
doaj +6 more sources
Tumor-specific but immunosuppressive CD39+CD8+ T cells exhibit double-faceted roles in clear cell renal cell carcinoma [PDF]
Cell Reports MedicineSummary: CD39+CD8+ T cells are known as tumor-antigen-specific cells among CD8+ tumor-infiltrating lymphocytes (TILs). However, CD39+CD8+ T cells also reportedly exhibit immunosuppressive activity in hypoxic tumor models.
Yong Joon Lee +22 more
doaj +2 more sources
Cancer immunotherapy by adenosinergic CD39 and CD73 as emerging immune checkpoints [PDF]
Discover OncologyExtracellular adenosine has recently been identified as an immunological checkpoint mediator that hinders the immune response to malignancies. The production of adenosine is facilitated by the enzymatic activity of CD39 and CD73.
Xinyu Yin, Ying Yang, Songjiang Liu
doaj +2 more sources
Indian Journal of Dermatology, 2023 Objectives: Peripheral blood immune cell profiling of atopic dermatitis patients before and after treatment by single-cell RNA sequencing technique has not been reported.
Xiao-Guang Gu +6 more
doaj +1 more source
Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report [PDF]
Iranian Journal of Immunology, 2022 Background: Impaired renal function is considered as a significant risk factor for cardiovascular events in chronic kidney disease patients. Several immunosuppressive drugs are used in these patients, which necessitates to minimize the drug-related side ...
Yaghoub Mollaei-Kandelous +7 more
doaj +1 more source
Pathogens, 2023 CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73 pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect.
Alaa Elsaghir +5 more
doaj +1 more source
Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct
OncoImmunology, 2022 Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li +10 more
doaj +1 more source
Frontiers in Immunology, 2021 Acute respiratory distress syndrome (ARDS) is characterized by an uncontrollable cytokine storm, which is associated with high mortality due to lack of effective treatment.
Cen Chen +19 more
doaj +1 more source
Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K +6 more
core +10 more sources
CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes. [PDF]
PLoS ONE, 2018 The ectoenzymes CD39 and CD73 degrade extracellular ATP to adenosine. ATP is released by stressed or damaged cells and provides pro-inflammatory signals to immune cells through P2 receptors.
Friederike Raczkowski +9 more
doaj +1 more source