Results 41 to 50 of about 34,165 (229)
Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment
Advanced Science, EarlyView.Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang +9 more
wiley +1 more source
Cell Reports MedicineSummary: CD39+CD8+ T cells are known as tumor-antigen-specific cells among CD8+ tumor-infiltrating lymphocytes (TILs). However, CD39+CD8+ T cells also reportedly exhibit immunosuppressive activity in hypoxic tumor models.
Yong Joon Lee +22 more
doaj +1 more source
CD25 and CD39 expression in CD4+ T cells.
, 2013 Compare results from HAM/TSP patients, HTLV-1 asymptomatic carriers (AC) and uninfected subjects.
Harry Wynn-Williams (280357) +10 more
core +1 more source
FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape
Advanced Science, EarlyView.FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu +14 more
wiley +1 more source
Purinergic Signaling as a Regulator of Th17 Cell Plasticity. [PDF]
PLoS ONE, 2016 T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation.
Dominique Fernández +17 more
doaj +1 more source
A humanized monoclonal antibody targeting CD39 with novel mechanism for cancer treatment
Medicine in Drug Discovery, 2021 ATP-adenosine signal axis plays an import role in tumor immune regulation. ATP released by tumor cells can promote antitumor immunity, and adenosine can suppress the immune response.
Zheng Wei +5 more
doaj +1 more source
Rat pancreas secretes particulate ecto-nucleotidase CD39
, 2003 Udgivelsesdato: 2003-Sep-15In exocrine pancreas, acini release ATP and the excurrent ducts express several types of purinergic P2 receptors. Thereby, ATP, or its hydrolytic products, might play a role as a paracrine regulator between acini and ducts. The
Ankorina-Stark, Ieva +4 more
core +1 more source
Advanced Science, EarlyView.A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu +6 more
wiley +1 more source
, 2019 (A) Determination of CD39 activity in cell membranes using three different cell lines, Farage cell (solid circle) has the highest CD39 activity using ATP as substrate.
Said A. Goueli (7548320) +1 more
core +1 more source
Treg inhibit IL-2 production via the CD39 pathway.
, 2013 (A) Using CD39 cell surface expression, Treg/CD39+ and Treg/CD39− were sorted and co-cultured with CFSE labeled CD4+CD45RA+CD25low naive T cells (ratio ½).
Ayrin Kök (214658) +12 more
core +1 more source