Results 41 to 50 of about 28,618 (205)

CD39 Modulates Endothelial Cell Activation and Apoptosis [PDF]

Molecular Medicine, 2000
CD39 is the dominant vascular nucleoside triphosphate diphosphohydrolase (NTPDase) that exerts major effects on platelet reactivity by the regulated hydrolysis of extracellular adenine nucleotides. The effects of NTPDases on endothelial cell (EC) activation and apoptosis remain unexplored.Recombinant replication-deficient adenoviruses were constructed ...
C, Goepfert, M, Imai, S, Brouard, E, Csizmadia, E, Kaczmarek, S C, Robson   +5 more
openaire   +2 more sources

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation

Frontiers in Immunology, 2022
The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory ...
Shi Qian, Shi Qian, Shi Qian, Chunbin Xiong, Chunbin Xiong, Meiting Wang, Meiting Wang, Zining Zhang, Zining Zhang, Yajing Fu, Yajing Fu, Qinghai Hu, Qinghai Hu, Haibo Ding, Haibo Ding, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han, Hong Shang, Hong Shang, Yongjun Jiang, Yongjun Jiang   +21 more
doaj   +1 more source

Functionally impaired CD103+CD39+CD8+ T cell subsets with immune-suppressive properties infiltrating gastric cancer tissues promote tumor progression

陆军军医大学学报
Objective To detect the infiltration level of CD103+CD39+CD8+ T cell subsets in gastric cancer tissues and analyze their response characteristics, clarifying the clinical relevance of this subset.
HUANG Mengqiu, ZHONG Hang
doaj   +1 more source

Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity

Journal for ImmunoTherapy of Cancer, 2019
Background Cancer cells are known to develop mechanisms to circumvent effective anti-tumor immunity. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP to adenosine ...
Abhishek S. Kashyap, Tamara Thelemann, Richard Klar, Sandra M. Kallert, Julia Festag, Melanie Buchi, Lisa Hinterwimmer, Monika Schell, Sven Michel, Frank Jaschinski, Alfred Zippelius   +10 more
doaj   +1 more source

In vitro Study of a Novel Stent Coating Using Modified CD39 Messenger RNA to Potentially Reduce Stent Angioplasty-Associated Complications. [PDF]

PLoS ONE, 2015
Stent angioplasty provides a minimally invasive treatment for atherosclerotic vessels. However, no treatment option for atherosclerosis-associated endothelial dysfunction, which is accompanied by a loss of CD39, is available, and hence, adverse effects ...
Meike-Kristin Abraham, Andrea Nolte, Rebekka Reus, Andreas Behring, Diane Zengerle, Meltem Avci-Adali, Jan David Hohmann, Karlheinz Peter, Christian Schlensak, Hans Peter Wendel, Stefanie Krajewski   +10 more
doaj   +1 more source

CD39 in the development and progression of pulmonary arterial hypertension

Purinergic Signalling, 2022
AbstractPulmonary arterial hypertension (PAH) is a devastating progressive disease characterised by pulmonary arterial vasoconstriction and vascular remodelling. Endothelial dysfunction has emerged as a contributing factor in the development of PAH. However, despite progress in the understanding of the pathophysiology of this disease, current therapies
Willcox, Abbey, Lee, Natasha Ting, Nandurkar, Harshal H., Sashindranath, Maithili   +3 more
openaire   +2 more sources

On the mechanism of anti-CD39 immune checkpoint therapy [PDF]

Journal for ImmunoTherapy of Cancer, 2020
With the coming of age of cancer immunotherapy, the search for new therapeutic targets has led to the identification of immunosuppressive adenosine as an important regulator of antitumor immunity. This resulted in the development of selective inhibitors targeting various components of the adenosinergic pathway, including small molecules antagonists ...
John Stagg, Bertrand Allard, David Allard   +2 more
openaire   +3 more sources

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Tumor-specific but immunosuppressive CD39+CD8+ T cells exhibit double-faceted roles in clear cell renal cell carcinoma

Cell Reports Medicine
Summary: CD39+CD8+ T cells are known as tumor-antigen-specific cells among CD8+ tumor-infiltrating lymphocytes (TILs). However, CD39+CD8+ T cells also reportedly exhibit immunosuppressive activity in hypoxic tumor models.
Yong Joon Lee, Seung Hyuck Jeon, Jin Hee Yeo, Sun-ju Byeon, Jae Hyung Jung, Heejin Nam, Minwoo Jeon, Eui-Soon Kim, Jeon Yeob Jang, Chul-Ho Kim, Kee Yang Chung, Jung Yun Lee, Shin Hwang, Jee Ye Kim, Seung-Il Kim, Jae-Ho Cheong, Chang Gon Kim, Sang Joon Shin, Su-Hyung Park, Minsun Jung, Minyong Kang, Seong Il Seo, Eui-Cheol Shin   +22 more
doaj   +1 more source

Expression of CD39 Is Correlated With HIV DNA Levels in Naïve Tregs in Chronically Infected ART Naïve Patients

Frontiers in Immunology, 2019
Background: Treg cells represent important viral reservoirs during chronic HIV infection. CD39 is closely involved in Treg-mediated immunosuppressive effects. However, CD39 expression on nTregs and mTregs and a relationship with HIV DNA levels during HIV
Jin-Wen Song, Hui-Huang Huang, Chao Zhang, Hong-Ge Yang, Ji-Yuan Zhang, Ruo-Nan Xu, Lei Jin, Ming Shi, Fu-Sheng Wang, Yan-Mei Jiao   +9 more
doaj   +1 more source