Results 41 to 50 of about 33,325 (191)

A humanized monoclonal antibody targeting CD39 with novel mechanism for cancer treatment

Medicine in Drug Discovery, 2021
ATP-adenosine signal axis plays an import role in tumor immune regulation. ATP released by tumor cells can promote antitumor immunity, and adenosine can suppress the immune response.
Zheng Wei, Fang Ren, Shiyong Gong, Beilei Shi, Kedong Ouyang, Chengbin Wu   +5 more
doaj   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration

, 2008
BACKGROUND & AIMS: Little is known about how endothelial cells respond to injury, regulate hepatocyte turnover and reconstitute the hepatic vasculature.
Enjyoji, K, Erb, L, Imai, M, Csizmadia, E, Wu, Y, Beldi, G, Sun, X, Robson, S.C., Candinas, D   +8 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Reduced Ki67 expression in CD4⁺CD39⁺ T cells following CD39 blocking.

, 2018
PBMC from microfilaremic (Fil+) and uninfected (Fil-) subjects were stained for intracellular Ki67, an indicator of T-cell proliferation. We first compared the proportion of Ki67+ cells among CD4+CD39+ and CD4+CD39- T cells (panel A) and CD39+ and CD39 ...
Marcelo U. Ferreira (138475), Raquel M. Gonçalves-Lopes (4288384), Nathália F. Lima (622805), Maria Yazdanbakhsh (90295), Yvonne C. M. Kruize (90288)   +4 more
core   +1 more source

Generation and characterization of antagonistic anti-human CD39 nanobodies

Frontiers in Immunology
CD39 is the major enzyme controlling the levels of extracellular adenosine triphosphate (ATP) via the stepwise hydrolysis of ATP to adenosine diphosphate (ADP) and adenosine monophosphate (AMP).
Stephan Menzel, Stephan Menzel, Stephan Menzel, Yinghui Duan, Julia Hambach, Birte Albrecht, Dorte Wendt-Cousin, Riekje Winzer, Eva Tolosa, Anne Rissiek, Anne Rissiek, Andreas H. Guse, Friedrich Haag, Tim Magnus, Friedrich Koch-Nolte, Björn Rissiek   +15 more
doaj   +1 more source

Interleukin‐2 Deprived State of Regulatory T cells and Their Recovery by Low‐Dose Interleukin‐2 in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

CD39 Regulation and Functions in T Cells

, 2021
CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the ...
Eleonora Timperi, Vincenzo Barnaba
core   +2 more sources

Electroacupuncture Alleviates Lung Injury in CpG1826-Challenged Mice via Modulating CD39-NLRP3 Pathway

Journal of Inflammation Research, 2023
Jiasi Wu, Xin Xiong, Xiumin Hu Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Jiasi Wu, Email wujiasi@cdutcm.edu.cnPurpose: Cytokine storm secondary lung ...
Wu J, Xiong X, Hu X
doaj