Results 41 to 50 of about 31,390 (228)

Targeting CD39 in cancer reveals an extracellular ATP- and inflammasome-driven tumor immunity [PDF]

, 2019
We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39 conversion of extracellular ATP (eATP) to AMP and thus potentially augment eATP-P2-mediated proinflammatory responses.
Robson, Simon C., Alana G. Lerner, Beers, Courtney, Welch, Megan, Jason Madore, Amelia Roman Aguilera, Smyth, Mark J, Tracy dela Cruz, Spatola, Bradley N, Lerner, Alana G., Kyohei Nakamura, Christos Xiao, Rebecca L. Johnston, Xian-Yang Li, Corbin, John, Maike Effern, Bald, Tobias, John Corbin, Clifford Wong, Johnston, Rebecca L, Soros, Vanessa B., Spatola, Bradley N., Nicola Waddell, Bradley N. Spatola, Li, Xian-Yang, Xiao, Christos, Lerner, Alana G, Tobias Bald, Courtney Beers, Haiyan Zhang, Sundarrajan, Ashmitha, Wong, Clifford, Teng, Michele WL, Vanessa B. Soros, Lepletier, Ailin, Megan Welch, Soros, Vanessa B, Geetha, Nishamol, Aguilera, Amelia Roman, Anderson, Ana C., Simon C. Robson, Smith, Corey, Johnston, Rebecca L., Anderson, Ana C, Ana C. Anderson, Ailin Lepletier, Madore, Jason, Moesta, Achim K, Robson, Simon C, Effern, Maike, Achim K. Moesta, Michael Hölzel, Mika Casey, Teng, Michele W L, Ashmitha Sundarrajan, Hölzel, Michael, Dela Cruz, Tracy, Waddell, Nicola, Jacoberger-Foissac, Celia, Corey Smith, Hoelzel, Michael, Celia Jacoberger-Foissac, Zhang, Haiyan, Mark J. Smyth, Moesta, Achim K., Nishamol Geetha, Nakamura, Kyohei, Michele W. L. Teng, Smyth, Mark J., Casey, Mika   +69 more
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Reducing Lung ATP Levels and Alleviating Asthmatic Airway Inflammation through Adeno-Associated Viral Vector-Mediated CD39 Expression

Biomedicines, 2021
Asthma is a chronic respiratory inflammatory disease. Patients usually suffer long-term symptoms and high medical expenses. Extracellular ATP (eATP) has been identified as a danger signal in innate immunity and serves as a potent inflammatory mediator ...
Yung-An Huang, Jeng-Chang Chen, Chih-Ching Wu, Chia-Wei Hsu, Albert Min-Shan Ko, Li-Chen Chen, Ming-Ling Kuo   +6 more
doaj   +1 more source

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]

, 2014
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H., Fountain, Samuel J., Sexton, D. W., Campwala, Hinnah, Fountain, SJ, Crossman, David C., Sexton, Darren W., Campwala, H, Crossman, D. C., Fountain, S. J., Sexton, DW, Crossman, DC   +11 more
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Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase [PDF]

Journal of Biological Chemistry, 1996
Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available from various mammalian and avian ATPDases revealed their close homology with CD39, a putative B-cell activation marker.
Kaczmarek, E, Katarzyna Agata Koziak, Sévigny, J, Siegel, JB, Anrather, J, Beaudoin, AR, Bach, FH, Robson, SC   +7 more
openaire   +2 more sources

CD39 Modulates Endothelial Cell Activation and Apoptosis [PDF]

Molecular Medicine, 2000
CD39 is the dominant vascular nucleoside triphosphate diphosphohydrolase (NTPDase) that exerts major effects on platelet reactivity by the regulated hydrolysis of extracellular adenine nucleotides. The effects of NTPDases on endothelial cell (EC) activation and apoptosis remain unexplored.Recombinant replication-deficient adenoviruses were constructed ...
C, Goepfert, M, Imai, S, Brouard, E, Csizmadia, E, Kaczmarek, S C, Robson   +5 more
openaire   +2 more sources

Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice [PDF]

, 2010
Natural killer (NK) cells play crucial roles in innate immunity and express CD39 (Ecto-nucleoside triphosphate diphosphohydrolase 1 [E-NTPD1]), a rate-limiting ectonucleotidase in the phosphohydrolysis of extracellular nucleotides to adenosine.
Robson, Simon C., Beldi, Guido, Enjyoji, Keiichi, Li, Xian, Graubardt, Nadine, Junger, Wolfgang G., Banz, Yara, Nowak, Martina, Candinas, Daniel, Sun, Xiaofeng, Wu, Yan, Kroemer, Alexander, Rellstab, Alyssa   +12 more
core   +1 more source

Functionally impaired CD103+CD39+CD8+ T cell subsets with immune-suppressive properties infiltrating gastric cancer tissues promote tumor progression

陆军军医大学学报
Objective To detect the infiltration level of CD103+CD39+CD8+ T cell subsets in gastric cancer tissues and analyze their response characteristics, clarifying the clinical relevance of this subset.
HUANG Mengqiu, ZHONG Hang
doaj   +1 more source

CD39 and CD161 Modulate Th17 Responses in Crohn's Disease [PDF]

, 2022
CD39 (ENTPD1) is expressed by subsets of pathogenic human CD4+ T cells, such as T helper type 17 (Th17) cells. These Th17 cells are considered important in intestinal inflammation, such as seen in Crohn’s disease. Recently, CD161 (NKR-P1A) has been shown
Moss, Alan, Gao, Wenda, Sun, Xiaofeng, Longhi, Maria Serena, Robson, Simon, Bai, Aiping, Cheifetz, Adam, Wu, Yan, Zheng, Yi, Kokkotou, Efi, Usheva, Anny   +10 more
core   +1 more source

Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. [PDF]

PLoS Neglected Tropical Diseases, 2013
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP.
Fabio E Leal, Lishomwa C Ndhlovu, Aaron M Hasenkrug, Fernanda R Bruno, Karina I Carvalho, Harry Wynn-Williams, Walter K Neto, Sabri S Sanabani, Aluisio C Segurado, Douglas F Nixon, Esper G Kallas   +10 more
doaj   +1 more source

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians [PDF]

, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Alfonso Cruz-Jentoft, Almudena Crooke, Martínez López, Joaquín, Martínez-Henández, Juan, Jesús Pintor, Crooke Álvarez, Almudena, Huete Toral, Fernando, Pintor, Jesús, Juan Martínez-Henández, Fernando Huete-Toral, Pintor Just, Jesús Jerónimo, Martínez-López, Joaquín, Crooke, Almudena, Cruz-Jentoft, Alfonso, Cruz Jentoft, Alfonso, Huete-Toral, Fernando, Joaquín Martínez-López, Martínez Henández, Juan   +17 more
core   +1 more source