High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors [PDF]
, 2015 One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects.
Aliagas Marín, Elisabeth +5 more
core +1 more source
CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta
Frontiers in Cell and Developmental Biology, 2023 Tissue insults in response to inflammation, hypoxia and ischemia are accompanied by the release of ATP into the extracellular space. There, ATP modulates several pathological processes, including chemotaxis, inflammasome induction and platelet activation.
Désirée Forstner +24 more
doaj +1 more source
Metabolic, mental and immunological effects of normoxic and hypoxic training in multiple sclerosis patients: a pilot study [PDF]
, 2018 Background: Physical activity might attenuate inflammation and neurodegeneration in multiple sclerosis (MS). Erythropoietin, which is produced upon exposure to hypoxia, is thought to act as a neuroprotective agent in MS. Therefore, we studied the effects
Balogh, Andras +9 more
core +3 more sources
CD39-adenosinergic axis in renal pathophysiology and therapeutics [PDF]
Purinergic Signalling, 2018 Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial biological functions. Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5'-nucleotidase.
Bellamkonda K. Kishore +2 more
openaire +2 more sources
In vitro Study of a Novel Stent Coating Using Modified CD39 Messenger RNA to Potentially Reduce Stent Angioplasty-Associated Complications. [PDF]
PLoS ONE, 2015 Stent angioplasty provides a minimally invasive treatment for atherosclerotic vessels. However, no treatment option for atherosclerosis-associated endothelial dysfunction, which is accompanied by a loss of CD39, is available, and hence, adverse effects ...
Meike-Kristin Abraham +10 more
doaj +1 more source
The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance [PDF]
, 2011 Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized.
Robson, Simon Christopher +2 more
core +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors [PDF]
Frontiers in Pharmacology, 2020 Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential as novel drugs for the (immuno)therapy of cancer. They increase the extracellular concentration of immunostimulatory ATP and reduce the formation of AMP, which can be further hydrolyzed by ecto-5'-nucleotidase (CD73) to immunosuppressive, cancer-promoting adenosine ...
Laura Schäkel +12 more
openaire +3 more sources
Frontiers in Immunology, 2019 Background: Treg cells represent important viral reservoirs during chronic HIV infection. CD39 is closely involved in Treg-mediated immunosuppressive effects. However, CD39 expression on nTregs and mTregs and a relationship with HIV DNA levels during HIV
Jin-Wen Song +9 more
doaj +1 more source
Circulating gluten-specific FOXP3 + CD39 + regulatory T cells have impaired suppressive function in patients with celiac disease [PDF]
, 2017 Background Celiac disease is a chronic immune-mediated inflammatory disorder of the gut triggered by dietary gluten. Although the effector T-cell response in patients with celiac disease has been well characterized, the role of regulatory T (Treg ...
Anderson, Robert P. +14 more
core +1 more source