Results 61 to 70 of about 34,165 (229)

CD39 in the development and progression of pulmonary arterial hypertension

Purinergic Signalling, 2022
AbstractPulmonary arterial hypertension (PAH) is a devastating progressive disease characterised by pulmonary arterial vasoconstriction and vascular remodelling. Endothelial dysfunction has emerged as a contributing factor in the development of PAH. However, despite progress in the understanding of the pathophysiology of this disease, current therapies
Willcox, Abbey, Lee, Natasha Ting, Nandurkar, Harshal H., Sashindranath, Maithili   +3 more
openaire   +2 more sources

Altered T cell immune profile and its prognostic implications in children with portal hypertension: A pilot study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Immune dysregulation in paediatric portal hypertension (PHT) is poorly understood. We aimed to characterise T cell phenotype and function and circulating immune mediators in children with PHT according to disease aetiology. Methods Forty‐four children with PHT (27 chronic liver disease [CLD]‐related and 17 portal vein thrombosis ...
Tengfei Si, Huihong Yu, Bethany Tucker, Fabiola Di Dato, Qing Shao, Xuan Luo, Cody Chan, Pauline Kane, Dylan Lewis, Eirini Kyrana, Yun Ma, Tassos Grammatikopoulos   +11 more
wiley   +1 more source

In vitro Study of a Novel Stent Coating Using Modified CD39 Messenger RNA to Potentially Reduce Stent Angioplasty-Associated Complications. [PDF]

PLoS ONE, 2015
Stent angioplasty provides a minimally invasive treatment for atherosclerotic vessels. However, no treatment option for atherosclerosis-associated endothelial dysfunction, which is accompanied by a loss of CD39, is available, and hence, adverse effects ...
Meike-Kristin Abraham, Andrea Nolte, Rebekka Reus, Andreas Behring, Diane Zengerle, Meltem Avci-Adali, Jan David Hohmann, Karlheinz Peter, Christian Schlensak, Hans Peter Wendel, Stefanie Krajewski   +10 more
doaj   +1 more source

Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase [PDF]

Journal of Biological Chemistry, 1996
Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available from various mammalian and avian ATPDases revealed their close homology with CD39, a putative B-cell activation marker.
Kaczmarek, E, Katarzyna Agata Koziak, Sévigny, J, Siegel, JB, Anrather, J, Beaudoin, AR, Bach, FH, Robson, SC   +7 more
openaire   +2 more sources

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy

Cancer Biology & Medicine
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages (TAMs), a key determinant of the tumor microenvironment (TME).
Lei Yang, Yi Zhang, Li Yang
doaj   +1 more source

Expression of CD39 Is Correlated With HIV DNA Levels in Naïve Tregs in Chronically Infected ART Naïve Patients

Frontiers in Immunology, 2019
Background: Treg cells represent important viral reservoirs during chronic HIV infection. CD39 is closely involved in Treg-mediated immunosuppressive effects. However, CD39 expression on nTregs and mTregs and a relationship with HIV DNA levels during HIV
Jin-Wen Song, Hui-Huang Huang, Chao Zhang, Hong-Ge Yang, Ji-Yuan Zhang, Ruo-Nan Xu, Lei Jin, Ming Shi, Fu-Sheng Wang, Yan-Mei Jiao   +9 more
doaj   +1 more source

TCRseq for "Merkel cell polyomavirus-specific and CD39+CLA+ CD8 T cells as blood-based predictive biomarkers for PD-1 blockade in Merkel cell carcinoma"

, 2023
MCC bulk TCR seq data (fastq) from sorted CD8 T cell populations (from PBMC) and tumor. CD39neg: CD39– CD8 T cells CD39pos: CD39+CLA–CD103– CD8 T cells CLA: CD39+CLA+ CD8 T cells CD103: CD39+CLA–CD103+ CD8 T ...
Ryu, Heeju
core   +1 more source

CD39 Modulates Endothelial Cell Activation and Apoptosis [PDF]

Molecular Medicine, 2000
CD39 is the dominant vascular nucleoside triphosphate diphosphohydrolase (NTPDase) that exerts major effects on platelet reactivity by the regulated hydrolysis of extracellular adenine nucleotides. The effects of NTPDases on endothelial cell (EC) activation and apoptosis remain unexplored.Recombinant replication-deficient adenoviruses were constructed ...
C, Goepfert, M, Imai, S, Brouard, E, Csizmadia, E, Kaczmarek, S C, Robson   +5 more
openaire   +2 more sources

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source