Results 61 to 70 of about 33,325 (191)

Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response

Biomolecules, 2023
In rheumatoid arthritis (RA) synovium, ATP, and ADP are released, sparking inflammation. Ectoenzymes CD39 and CD73 metabolize these purine nucleotides, generating anti-inflammatory adenosine. Therefore, dysregulated CD39 and CD73 expression may impact RA
María Angels Ortiz, Cesar Diaz-Torné, Juan Jose De Agustin, Paula Estrada, Delia Reina, María Victoria Hernandez, Hye Sang, Carlos Zamora, Elisabet Cantó, Hector Corominas, Silvia Vidal   +10 more
doaj   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Targeting CD39 in cancer reveals an extracellular ATP- and inflammasome-driven tumor immunity

, 2019
We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39 conversion of extracellular ATP (eATP) to AMP and thus potentially augment eATP-P2-mediated proinflammatory responses.
Robson, Simon C., Alana G. Lerner, Beers, Courtney, Welch, Megan, Jason Madore, Amelia Roman Aguilera, Smyth, Mark J, Tracy dela Cruz, Spatola, Bradley N, Lerner, Alana G., Kyohei Nakamura, Christos Xiao, Rebecca L. Johnston, Xian-Yang Li, Corbin, John, Maike Effern, Bald, Tobias, John Corbin, Clifford Wong, Johnston, Rebecca L, Soros, Vanessa B., Spatola, Bradley N., Nicola Waddell, Bradley N. Spatola, Li, Xian-Yang, Xiao, Christos, Lerner, Alana G, Tobias Bald, Courtney Beers, Haiyan Zhang, Sundarrajan, Ashmitha, Wong, Clifford, Teng, Michele WL, Vanessa B. Soros, Lepletier, Ailin, Megan Welch, Soros, Vanessa B, Geetha, Nishamol, Aguilera, Amelia Roman, Anderson, Ana C., Simon C. Robson, Smith, Corey, Johnston, Rebecca L., Anderson, Ana C, Ana C. Anderson, Ailin Lepletier, Madore, Jason, Moesta, Achim K, Robson, Simon C, Effern, Maike, Achim K. Moesta, Michael Hölzel, Mika Casey, Teng, Michele W L, Ashmitha Sundarrajan, Hölzel, Michael, Dela Cruz, Tracy, Waddell, Nicola, Jacoberger-Foissac, Celia, Corey Smith, Hoelzel, Michael, Celia Jacoberger-Foissac, Zhang, Haiyan, Mark J. Smyth, Moesta, Achim K., Nishamol Geetha, Nakamura, Kyohei, Michele W. L. Teng, Smyth, Mark J., Casey, Mika   +69 more
core   +1 more source

High circulating CD39+ regulatory T cells predict poor survival for sepsis patients

International Journal of Infectious Diseases, 2015
Background: Sepsis encompasses two phases, the ‘hyper’-reactive phase and the ‘hypo’-reactive phase. The initial inflammatory stage is quickly counterbalanced by an anti-inflammatory response, which compromises the immune system, leading to immune ...
Huihuang Huang, Ruonan Xu, Fang Lin, Chunmei Bao, Siyu Wang, Chengcheng Ji, Ke Li, Lei Jin, Jingsong Mu, Yonggang Wang, Lei Li, Lijian Sun, Biao Xu, Zheng Zhang, Fu-Sheng Wang   +14 more
doaj   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Hydrolysis of extracellular ATP to adenosine (eADO) is an important immune checkpoint in cancer immunology. We here investigated the impact of the eADO pathway in high-grade serous ovarian cancer (HGSC) using multiparametric platforms.Methods ...
John Stagg, Anne-Marie Mes-Masson, Rejean Lapointe, Pamela Thebault, David Allard, Isabelle Cousineau, Yacine Bareche, Sandra Pommey, Mayra Carneiro, Laurence Buisseret, Pavel Chrobak, Laudine Communal, Simon C Robson, Diane Provencher   +13 more
doaj   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice

, 2010
Natural killer (NK) cells play crucial roles in innate immunity and express CD39 (Ecto-nucleoside triphosphate diphosphohydrolase 1 [E-NTPD1]), a rate-limiting ectonucleotidase in the phosphohydrolysis of extracellular nucleotides to adenosine.
Robson, Simon C., Beldi, Guido, Enjyoji, Keiichi, Li, Xian, Graubardt, Nadine, Junger, Wolfgang G., Banz, Yara, Nowak, Martina, Candinas, Daniel, Sun, Xiaofeng, Wu, Yan, Kroemer, Alexander, Rellstab, Alyssa   +12 more
core   +1 more source

Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

Hematology/Oncology and Stem Cell Therapy, 2019
Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune ...
Eman Mosaad Zaki, Asmaa Mohamed Zahran, Alshimaa Abdelazeem Metwaly, Rania Hafez, Safinaz Hussein, Abdallah Elaiw Mohammed   +5 more
doaj   +1 more source