Results 81 to 90 of about 34,165 (229)

RNAseq for "Merkel cell polyomavirus-specific and CD39+CLA+ CD8 T cells as blood-based predictive biomarkers for PD-1 blockade in Merkel cell carcinoma"

, 2023
MCC bulk RNA seq data (BAM) from sorted CD9 T cell populations (from PBMC). CD39neg: CD39– CD8 T cells CD39pos: CD39+CLA–CD103– CD8 T cells CLA: CD39+CLA+ CD8 T cells CD103: CD39+CLA–CD103+ CD8 T ...
Ryu, Heeju
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

, 2015
International audienceThe ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell ...
Eliaou, Jean-François, Stéphanie Cochaud, Nicole Bec, Nathalie Bonnefoy, Gilles Alberici, Jeremy Bastid, Anne Regairaz, Jérôme Giustiniani, Bonnefoy, Nathalie, Elisa Funck-Brentano, Giustiniani, Jérôme, Patrice Hemon, Laheurte, Caroline, Hemon, Patrice, Bec, Nicole, Cécile Déjou, Emilie Laprevotte, Laprevotte, Emilie, Jean-François Eliaou, Larroque, Christian, Caroline Laheurte, Armand Bensussan, Dejou, Cécile, Cochaud, Stéphanie, Bensussan, Armand, Regairaz, Anne, Christian Larroque, Bastid, Jérémy, Funck-Brentano, Elisa, Laurent Gros, Gros, Laurent, Alberici, Gilles   +31 more
core   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Hepatic Arachidonic Acid Dysregulation Impairs Double-Negative Regulatory T Cell-Mediated Immunoregulation via CD39 Downregulation and Drives MASLD Development

Journal of Immunology Research
Immune dysregulation is a key driver of metabolic dysfunction-associated steatotic liver disease (MASLD). Double-negative regulatory T (DNT) cells, which are essential for hepatic immune homeostasis, are functionally impaired in MASLD.
Hua Jin, Xiyu Wang, Xinjuan Liu, Dong Zhang, Guangyong Sun   +4 more
doaj   +1 more source

CD39-adenosinergic axis in renal pathophysiology and therapeutics

, 2018
© 2018, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial biological functions.
SC Robson (14541245), KM Dwyer (14448135), BK Kishore (14541434)   +2 more
core  

Unleashing the potential of CD39-targeted cancer therapy: Breaking new ground and future prospects [PDF]

The review article titled CD39 Transforming Cancer Therapy by Modulating Tumor Microenvironment published in June 2024 in Cancer Letters provides a comprehensive overview of CD39's multifaceted roles in cancer, particularly its influence on ...
Minev, Theia, Shao, Shengwen, Ma, Wenxue, Zhou, Qiongyan   +3 more
core   +1 more source

Genetic Engineering of Tumor‐Infiltrating Lymphocytes (TIL) via a T‐Editor Platform to Enhance Anti‐Tumor Activity

Cancer Science, EarlyView.
A rapid and efficient CRISPR‐mediated gene editing platform for TIL engineering identified FAM84B as a novel potential target to enhance antitumor activity and pioneered the use of CBE to generate FAM84B loss‐of‐function TIL with enhanced antitumor activity.
Fenge Li, Xuejiao Ma, Yongming Xue, Jilong Yang, Ruijing Wang, Xiang Li, Chao Zhang, Wenhan Lu, Mei Liu, Yue Xu, Xinyi Wang, Shengnan Wu, Ning Kang, Chunhua Ma   +13 more
wiley   +1 more source

CD39 expression defines exhausted CD4+ T cells associated with poor survival and immune evasion in human gastric cancer

Clinical & Translational Immunology
Objectives CD4+ T cell helper and regulatory function in human cancers has been well characterised. However, the definition of tumor‐infiltrating CD4+ T cell exhaustion and how it contributes to the immune response and disease progression in human ...
Zhen‐quan Duan, Yu‐xian Li, Yuan Qiu, Yang Shen, Ying Wang, Yuan‐yuan Zhang, Bao‐hang Zhu, Xiao‐hong Yu, Xue‐ling Tan, Weisan Chen, Yuan Zhuang, Ping Cheng, Wei‐jun Zhang, Quan‐ming Zou, Dai‐yuan Ma, Liu‐sheng Peng   +15 more
doaj   +1 more source

Characterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation

, 2021
Traditional antithrombotic agents commonly share a therapy-limiting side effect, as they increase the overall systemic bleeding risk. A novel approach for targeted antithrombotic therapy is nanoparticles.
Konstantin Krutzke, Netanel Korin, Meinrad Paul Gawaz, Alexander Bild, Jeremy A. Nestele, Daniela Eißler, Moran Levi, Valerie Dicenta, Anne-Katrin Rohlfing, Marcel Kremser, Frederic Emschermann, Oliver Borst, Tilman E. Schäffer   +12 more
core   +1 more source