Results 81 to 90 of about 38,336 (234)

Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia [PDF]

, 2014
Microglia are myeloid cells of the central nervous system (CNS) that participate both in normal CNS function and disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that were uniquely or highly expressed
Antel, Jack P., Butovsky, Oleg, Chen, Zhuoxun, Cialic, Ron, Dake, Ben, Doykan, Camille E., Fanek, Zain, Gabriely, Galina, Gygi, Steven P., Jedrychowski, Mark P., Koeglsperger, Thomas, Lanser, Amanda J., Liu, LiPing, Moore, Craig S., Ransohoff, Richard M., Rothstein, Jeffrey D., Weiner, Howard L., Wu, Pauline M.   +17 more
core   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

CD39/Adenosine Pathway Is Involved in AIDS Progression

PLoS Pathogens, 2011
HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in
Nikolova, Maria, Carriere, Matthieu, Jenabian, Mohammad-Ali, Limou, Sophie, Younas, Mehwish, Kök, Ayrin, Huë, Sophie, Seddiki, Nabila, Hulin, Anne, Delaneau, Olivier, Schuitemaker, Hanneke, Herbeck, Joshua, Mullins, James, Muhtarova, Maria, Bensussan, Armand, Zagury, Jean-François, Lelievre, Jean-Daniel, Lévy, Yves   +17 more
openaire   +8 more sources

Regulation of the T Cell Response by CD39 [PDF]

Trends in Immunology, 2016
The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. CD39 generates AMP, which is in turn used by the ecto-5'-nucleotidase CD73 to synthesize adenosine.
Maisa C, Takenaka, Simon, Robson, Francisco J, Quintana   +2 more
openaire   +2 more sources

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse [PDF]

Cardiovascular Research, 2009
Extracellular nucleotides are vasoactive molecules. The concentrations of these molecules are regulated by ectonucleotidases. In this study, we investigated the role of the blood vessel ectonucleotidase NTPDase1, in the vasoconstrictor effect of nucleotides using Entpd1(-/-) mice.Immunofluorescence, enzyme histochemistry, and HPLC analysis were used to
Kauffenstein, Gilles, Drouin, Annick, Thorin-Trescases, Nathalie, Bachelard, Hélène, Robaye, Bernard, D'Orléans-Juste, Pedro, Marceau, François, Thorin, Eric, Sévigny, Jean   +8 more
openaire   +2 more sources

Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism

mAbs, 2020
The extracellular ATP/adenosine axis in the tumor microenvironment (TME) has emerged as an important immune-regulatory pathway. Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), otherwise known as CD39, is highly expressed in the TME, both on ...
Bradley N. Spatola, Alana G. Lerner, Clifford Wong, Tracy dela Cruz, Megan Welch, Wanchi Fung, Maria Kovalenko, Karolina Losenkova, Gennady G. Yegutkin, Courtney Beers, John Corbin, Vanessa B. Soros   +11 more
doaj   +1 more source

Potential benefits and risks of clinical xenotransplantation [PDF]

, 2012
The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core   +2 more sources

Immune Imbalance in Sickle Cell Anemia: Flow Cytometric Insights Into Regulatory T Cells and Neutrophil Dynamics

Journal of Clinical Laboratory Analysis, EarlyView.
Flow cytometric analysis in sickle cell anemia reveals preserved Treg frequency despite decreased CD25 expression and increased neutrophil activity, highlighting a complex immune imbalance. The proportions of both neutrophil and lymphocyte cells have been shown to be a reliable predictor of CD3+ T cell levels, thus emphasizing the importance of innate ...
Rukiye Ölçüoğlu, Funda Tanrıkulu, Sevtap Kılınç, Eda Çakmak, Süheyl Asma, Can Boğa, Hakan Özdoğu, İlknur Pamuk   +7 more
wiley   +1 more source

CD39 expression defines exhausted CD4+ T cells associated with poor survival and immune evasion in human gastric cancer

Clinical & Translational Immunology
Objectives CD4+ T cell helper and regulatory function in human cancers has been well characterised. However, the definition of tumor‐infiltrating CD4+ T cell exhaustion and how it contributes to the immune response and disease progression in human ...
Zhen‐quan Duan, Yu‐xian Li, Yuan Qiu, Yang Shen, Ying Wang, Yuan‐yuan Zhang, Bao‐hang Zhu, Xiao‐hong Yu, Xue‐ling Tan, Weisan Chen, Yuan Zhuang, Ping Cheng, Wei‐jun Zhang, Quan‐ming Zou, Dai‐yuan Ma, Liu‐sheng Peng   +15 more
doaj   +1 more source