Results 91 to 100 of about 34,165 (229)
Cancer Science, EarlyView.Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang +6 more
wiley +1 more source
mAbs, 2020 The extracellular ATP/adenosine axis in the tumor microenvironment (TME) has emerged as an important immune-regulatory pathway. Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), otherwise known as CD39, is highly expressed in the TME, both on ...
Bradley N. Spatola +11 more
doaj +1 more source
Targeting CD39 as a Therapeutic for Cancer Immunotherapy
Expert Reviews in Molecular MedicineAbstract CD39 plays a pivotal role in the ATP-to-adenosine signalling pathway, serving as a critical mediator of immune suppression within the tumour microenvironment. Increasing preclinical evidence indicates that its inhibition can restore antitumour immunity and improve the efficacy of established treatments.
Zhongliang Li, Weiguo Xu, Hang Fai Kwok
openaire +2 more sources
Lactate and Lactylation: What We Know and What We Expect in Tumour Progression
Cell Proliferation, EarlyView.Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley +1 more source
In vitro NAD+ supplementation increases CD4+ and CD8+ T cell function in people with HIV
HIV Medicine, EarlyView.Abstract Objectives HIV perturbs T cell homeostasis and disrupts immune function, increasing the risk of age‐associated comorbidities. Ageing people with HIV (PWH) have exacerbated expression of CD38 on T cells, which depletes intracellular nicotinamide adenine dinucleotide (NAD+).
Guangming Li +5 more
wiley +1 more source
Research progress of CD39-CD73-adenosine pathway in immune regulation of hepatocellular carcinoma
Zhongguo Linchuang YixueHepatocellular carcinoma (HCC) patients accounts for 85%-90% of all primary liver cancer patients. Surgical treatment methods, represented by resection and liver transplantation, have relatively good efficacy and are currently the preferred treatment ...
Lin SUN, Beili WANG, Wei GUO
doaj +1 more source
Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
Nature Communications, 2020 CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelioration ...
Rasika P. Harshe +14 more
doaj +1 more source
Vector map, generation and purification of CD39 mRNA.
, 2015 (A) Vector map of the pcDNA 3.3 plasmid containing the ENTDP-1/CD39 construct for mammalian expression. (B) Electrophoresis with a 1% agarose-TBE gel of the purified CD39 mRNA (1533 bp). eGFP mRNA (993 bp) was used as a loading control.
Andrea Nolte (797371) +10 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida +4 more
wiley +1 more source
Generation and characterization of nanobodies against the ecto-enzymes CD39/CD73 [PDF]
, 2021 CD39 and CD73 are the two key ecto-enzymes in the process of converting pro-inflammatory ATP into anti-inflammatory adenosine. The enzymatic activity of both ecto-enzymes modulates the course inflammation associated diseases, including cancer.
Duan, Yinghui
core