Results 91 to 100 of about 31,390 (228)

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

Hematology/Oncology and Stem Cell Therapy, 2019
Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune ...
Eman Mosaad Zaki, Asmaa Mohamed Zahran, Alshimaa Abdelazeem Metwaly, Rania Hafez, Safinaz Hussein, Abdallah Elaiw Mohammed   +5 more
doaj   +1 more source

High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Hydrolysis of extracellular ATP to adenosine (eADO) is an important immune checkpoint in cancer immunology. We here investigated the impact of the eADO pathway in high-grade serous ovarian cancer (HGSC) using multiparametric platforms.Methods ...
John Stagg, Anne-Marie Mes-Masson, Rejean Lapointe, Pamela Thebault, David Allard, Isabelle Cousineau, Yacine Bareche, Sandra Pommey, Mayra Carneiro, Laurence Buisseret, Pavel Chrobak, Laudine Communal, Simon C Robson, Diane Provencher   +13 more
doaj   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration [PDF]

, 2008
Microglia is activated by brain injury. They migrate in response to ATP and although adenosine alone has no effect on wild type microglial migration, we show that inhibition of adenosine receptors impedes ATP triggered migration.
Gertz, K., Simon C. Robson, Enjyoji, K., Faerber, K., Nolte, C., Prinz, V., Ulrike Pannasch, Markworth, S., Pannasch, U., Endres, M., Vincent Prinz, Kettenmann, H., Kronenberg, G., Keiichi Enjyoji, Sören Markworth, Ingo Bechmann, Katrin Färber, Christiane Nolte, Golo Kronenberg, Matthias Endres, Helmut Kettenmann, Bechmann, I., Karen Gertz, Robson, S.C.   +23 more
core   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

CD25 and CD39 expression in CD4⁺ T cells. [PDF]

, 2013
Compare results from HAM/TSP patients, HTLV-1 asymptomatic carriers (AC) and uninfected subjects.
Harry Wynn-Williams (280357), Sabri S. Sanabani (166413), Douglas F. Nixon (68367), Lishomwa C. Ndhlovu (132462), Fernanda R. Bruno (280354), Karina I. Carvalho (244966), Aaron M. Hasenkrug (154303), Walter K. Neto (280358), Aluisio C. Segurado (280360), Esper G. Kallas (36139), Fabio E. Leal (280352)   +10 more
core   +1 more source

A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection

Alimentary Pharmacology &Therapeutics, EarlyView.
Cirrhosis patients with untreated HBV in Ethiopia exhibit a distinct immune profile marked by depletion of NK cells, B cells, and T cells, alongside an expanded CD38+HLA‐DR+ CD8 T‐cell population. ABSTRACT Background and Aims The immune cell phenotype of African patients living with chronic hepatitis B virus (HBV) infection is rarely described, despite
Julia MacLeod, Fikadu G. Gudissa, Asiya Jeylan, Nega Berhe, Hailemichael Desalegn, Lasse Rossvoll, Asgeir Johannessen, Niklas K. Björkström, Dag Henrik Reikvam, Annika Niehrs   +9 more
wiley   +1 more source

Treg inhibit IL-2 production via the CD39 pathway. [PDF]

, 2013
(A) Using CD39 cell surface expression, Treg/CD39+ and Treg/CD39− were sorted and co-cultured with CFSE labeled CD4+CD45RA+CD25low naive T cells (ratio ½).
Ayrin Kök (214658), Nabila Seddiki (214661), Matthieu Carriere (214642), Elnaz Ghadimi (407444), Alain Tremblay (407445), Jean-Pierre Routy (118465), Jean-Daniel Lelievre (170842), Yves Levy (119516), Jean Sévigny (183762), Anne Hulin (214665), Mohammad-Ali Jenabian (49586), Ahmad Yatim (407443), Mehwish Younas (214656)   +12 more
core   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, EarlyView.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source