Results 101 to 110 of about 33,325 (191)
Rapamycin Regulates iTreg Function through CD39 and Runx1 Pathways [PDF]
, 2014 It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression.
Ling Lu +9 more
core +1 more source
MedComm – Oncology, Volume 5, Issue 3, September 2026.The up‐to‐date clinical progress of immune checkpoint inhibitor (ICI) therapy in solid tumors, specifically the combinational regimens between ICIs and other treatment strategies, the mechanisms underlying primary and acquired resistance, and mechanism‐matched strategies to improve clinical outcomes are synthesized in this review.
Qiongyu Zhang, Zhi Qin, Caijuan Guo
wiley +1 more source
CD39 regulates cerebrovascular dysfunction during sepsis 2334223
Introduction Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Vascular alterations play a central role, promoting endothelial barrier disruption and neuroinflammation, key features of
Simon Robson +9 more
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Inhibitor selectivity using purified and membrane associated CD39.
, 2019 Inhibitors of CD39 and CD73 were incubated with purified CD39 (A, B) and Farage associated enzyme (C, D) and assayed for CD39 activity using ATP (A, C) or ADP (B, D) as substrate.
Said A. Goueli (7548320) +1 more
core +1 more source
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas [PDF]
, 1998 Ecto-ATPase activities of melanocytes and human melanoma cell lines differing in the stage of progression were compared. A dramatic increase in ecto-ATPase activity above the level of normal melanocytes was demonstrated in the differentiated melanomas ...
Dzhandzhugazyan, Karine N +7 more
core +1 more source
PlateletsDue to platelet storage lesions (PSL), transfused platelets are unable to function properly in the prevention and treatment of bleeding in critically ill patients.
Cheng Liu +6 more
doaj +1 more source
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
Precision Medical Sciences, Volume 15, Issue 3, Page 176-193, September 2026.This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
Expression of CD39 and CD73 ectonucleotidases and associated ectoenzymatic activity.
, 2014 (A) Mean (+SEM) frequency of (A) CD39+ cells, (B) CD39 mean fluorescence intensity (MFI) and of (C) CD39+CD73+ cells within CD4mem at baseline and within Th17, iT-reg and supTh17. Results from 12 healthy subjects are shown. *P≤0.05; **P≤0.01; ***P≤0.001.
Yan Wu (70890) +7 more
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Precision Radiation Oncology, Volume 10, Issue 3, Page 417-427, September 2026.The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu +4 more
wiley +1 more source
, 2015 Flow cytometric analyses of transfected HEK293 cells (A) human ECs (B) and immortalized porcine endothelial cells (PAE; C) with different CD39 mRNA concentrations. For control untreated and Lipofectamin-treated cells were used.
Andrea Nolte (797371) +10 more
core +1 more source