Results 101 to 110 of about 34,165 (229)
Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation
The Journal of Physiology, EarlyView.Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min +2 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 11, Page 2569-2583, November 2026.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy with limited treatment options and a dismal prognosis. The tumor immune microenvironment (TIME) is crucial for iCCA progression, yet its comprehensive characterization remains ...
Qi-Wei Zhang +8 more
core +1 more source
, 2015 Flow cytometric analyses of transfected HEK293 cells (A) human ECs (B) and immortalized porcine endothelial cells (PAE; C) with different CD39 mRNA concentrations. For control untreated and Lipofectamin-treated cells were used.
Andrea Nolte (797371) +10 more
core +1 more source
Arthritis &Rheumatology, Volume 78, Issue 11, Page 2341-2350, November 2026.Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes +10 more
wiley +1 more source
Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals
Cell Reports, 2016 Summary: In an immune response, CD4+ T cells expand into effector T cells and then contract to survive as long-lived memory cells. To identify age-associated defects in memory cell formation, we profiled activated CD4+ T cells and found an increased ...
Fengqin Fang +12 more
doaj +1 more source
Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens [PDF]
, 2016 SummaryIn humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood.
Idzko, Marco +11 more
core +1 more source
Cell Biology International, Volume 50, Issue 11, November 2026.ABSTRACT Hepatocellular carcinoma (HCC), a lethal form of liver cancer, continues to show rising mortality rates despite advancements in immunotherapies. This highlights the need for more effective treatments. Recent studies linked the presence of B cells within human tumors, including HCC, to improved responses to immunotherapy and better prognoses ...
Fang Wang +3 more
wiley +1 more source
CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression
, 2015 International audienceWe report that CD39-expressing-melanoma cells inhibited both T-cell proliferation and the generation of cytotoxic effectors in an adenosine-dependent manner, and that treatment with a CD39-blocking antibody alleviated tumor-mediated
Eliaou, Jean-François +3 more
core +1 more source
NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD [PDF]
, 2016 Purinergic receptor activation via extracellular ATP is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Nucleoside triphosphate diphosphohydrolase-1/CD39 hydrolyses extracellular ATP and modulates P2 receptor signalling.We ...
Robson, Simon C. +32 more
core +1 more source