Results 101 to 110 of about 31,390 (228)
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, EarlyView.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
mAbs, 2020 The extracellular ATP/adenosine axis in the tumor microenvironment (TME) has emerged as an important immune-regulatory pathway. Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), otherwise known as CD39, is highly expressed in the TME, both on ...
Bradley N. Spatola +11 more
doaj +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo +2 more
wiley +1 more source
Clinical & Translational ImmunologyObjectives CD4+ T cell helper and regulatory function in human cancers has been well characterised. However, the definition of tumor‐infiltrating CD4+ T cell exhaustion and how it contributes to the immune response and disease progression in human ...
Zhen‐quan Duan +15 more
doaj +1 more source
Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment
Immunology &Cell Biology, EarlyView.Three interconnected processes in glioblastoma (GBM) biology: initiation, stratification, and immunosuppression. 1) Initiation: GBM initiation is proposed to occur through migration of TERT mutation‐bearing neural stem cells from the subventricular zone to the frontal and temporal cortices, where a subsequent oncogenic transformation drives their ...
Emerson Achari +6 more
wiley +1 more source
Rapamycin Regulates iTreg Function through CD39 and Runx1 Pathways [PDF]
, 2014 It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression.
Ling Lu +9 more
core +1 more source
Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
Nature Communications, 2020 CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelioration ...
Rasika P. Harshe +14 more
doaj +1 more source
Immunology &Cell Biology, EarlyView.This study found that BLIMP‐1 is highly expressed in activated effector/memory human regulatory T cells, especially CD39+ Tregs, where it is associated with increased IL‐10 production and a conserved phenotype across blood and lung tissues during immune responses such as SARS‐CoV‐2 infection.
Chansavath Phetsouphanh +10 more
wiley +1 more source
Characterisation of human antigen-specific CD4+CD39+ regulatory T cells [PDF]
, 2014 Human antigen-specific CD4+ T cells can be detected through the dual expression of CD134 (OX40) and CD25 after 44 hours stimulation with cognate antigen. Work in this thesis demonstrates that differential surface expression of CD39 on these cells enables
Cook, Laura
core +2 more sources
Research progress of CD39-CD73-adenosine pathway in immune regulation of hepatocellular carcinoma
Zhongguo Linchuang YixueHepatocellular carcinoma (HCC) patients accounts for 85%-90% of all primary liver cancer patients. Surgical treatment methods, represented by resection and liver transplantation, have relatively good efficacy and are currently the preferred treatment ...
Lin SUN, Beili WANG, Wei GUO
doaj +1 more source