Results 111 to 120 of about 34,165 (229)

The role of the adenosinergic pathway in resistance to hypomethylating agents in patients with high‐risk myelodysplastic syndromes

British Journal of Haematology, EarlyView.
George Vrachiolias, Eleftheria Lamprianidou, Athanasios Tasis, Theodoros Spyropoulos, Despoina Dimitriou, Chryssa Kymparidou, Christina Misidou, Konstantinos Liapis, Emmanouil Spanoudakis, Maria Koffa, Menelaos Papoutselis, Iliana Stamatiou, Elsa Bernard, Elli Papaemmanuil, Ioannis Mitroulis, Ioannis Kotsianidis   +15 more
wiley   +1 more source

Serpin A1 Cargo Within Tumour‐Derived Extracellular Vesicles Supports Pro‐Tumoural Bias of Neutrophils in Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
ABSTRACT Tumour‐derived extracellular vesicles (EVs) or exosomes are critical mediators of the cancer‐immune system crosstalk, yet the mechanisms by which they reprogram neutrophil function in vivo remain insufficiently characterised. Here, we identify the serine protease inhibitor Serpin A1 as a predominant cargo component of small EVs (sEVs) released
Maksim Domnich, Ekaterina Pylaeva, Elena Siakaeva, Nastassia Kabankova, Agnieszka Bedzinska, Damian Sojka, Aneta Zebrowska, Marta Gawin, Maren Soldierer, Yaping Yu, Malwina Rist, Daniel Fochtman, Bernd Giebel, Iris Helfrich, Ilona Thiel, Basant Kumar Thakur, Cornelius H. L. Kürten, Helmut Hanenberg, Sonja Ludwig, Piotr Widlak, Stephan Lang, Monika Pietrowska, Jadwiga Jablonska   +22 more
wiley   +1 more source

Genotypic‐Phenotypic Correlations in Non‐HbE β‐Thalassemia Intermedia: A Geographic Systematic Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 11, November 2026.
β‐Thalassemia intermedia exhibits distinct region‐specific molecular patterns shaped by three interacting genetic axes: β‐globin mutation severity, HbF‐inducing modifiers, and α‐globin gene dosage. Mediterranean populations are predominantly mutation‐driven, Middle Eastern populations rely on HbF compensation, and Asian populations are governed by ...
Kavindya Fernando, Shiromi Perera, Anuja Premawardhena   +2 more
wiley   +1 more source

CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia

Journal of Translational Medicine, 2007
Background Chronic lymphocytic leukemia (CLL) is characterized by accumulation of mature appearing lymphocytes and is rarely complicated by thrombosis. One possible explanation for the paucity of thrombotic events in these patients may be the presence of
Islam Naziba, Broekman M Johan, Olson Kim E, Pulte Dianne, Ballard Harold S, Furman Richard R, Olson Ashley E, Marcus Aaron J   +7 more
doaj   +1 more source

RanBPM associates with CD39 and modulates ecto-nucleotidase activity

, 2006
CD39/ecto-NTPDase 1 (nucleoside triphosphate diphosphohydrolase 1) is an ecto-nucleotidase that influences P2 receptor activation to regulate vascular and immune cell adhesion and signalling events pivotal in inflammation.
Y Wu (808222), SC Robson (14541245), A Usheva (13612159), KM Dwyer (14448135), X Sun (6794357), E Bianchi (13612156), E Kaczmarek (13612153)   +6 more
core  

Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration

, 2008
BACKGROUND & AIMS: Little is known about how endothelial cells respond to injury, regulate hepatocyte turnover and reconstitute the hepatic vasculature.
Enjyoji, K, Erb, L, Imai, M, Csizmadia, E, Wu, Y, Beldi, G, Sun, X, Robson, S.C., Candinas, D, Robson, Simon C., Beldi, Guido, Enjyoji, Keiichi, Imai, Masato, Csizmadia, Eva, Candinas, Daniel, Sun, Xiaofeng, Erb, Laurie, Wu, Yan   +17 more
core   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

신세포암에서 종양침윤 CD39+CD8+ T세포의 특성에 대한 연구

, 2022
학위논문(박사) - 한국과학기술원 : 의과학대학원, 2022.2,[v, 57 p. :]Despite CD39 expression on tumor-infiltrating $CD8^+$ T cells have been mostly highlighted as a marker for exhausted cells or tumor antigen-reactive cells, CD39 is known to play a role in immuno-suppressive
Lee, Yong Joon
core  

CD39-Diannexin alleviates the platelet storage lesion by protecting platelets from activation, a new attempt from a traditional perspective

Platelets
Due to platelet storage lesions (PSL), transfused platelets are unable to function properly in the prevention and treatment of bleeding in critically ill patients.
Cheng Liu, Peng Wang, Yafei Gao, Xiaolong Ma, Yang Su, Yao Wei, Rui Qiao   +6 more
doaj   +1 more source

Regulatory T Cells In Transplantation: Does Extracellular Adenosine Triphosphate Metabolism Through Cd39 Play A Crucial Role?

, 2010
Despite Tremendous Improvements In Short-Term Renal Allograft Survival, Many Patients Still Have Chronic Rejection Or Side Effects Of Nonspecific Immunosuppression.
Falk, K, Roetzschke, O., Tam, PKH, Rotzschke, O, Falk, K., Tam, P., Salcido-Ochoa, F., Tsang, J, Salcido-Ochoa, F, Tsang, J., Julia Tsang, Francisco Salcido-Ochoa, Paul Tam, Olaf Rotzschke, Kirsten Falk   +14 more
core   +1 more source