Results 111 to 120 of about 31,390 (228)
The Journal of Physiology, EarlyView.Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida +4 more
wiley +1 more source
The Role of CD39 in Cardiovascular Disease. [PDF]
, 2009 While ATP and ADP are traditionally thought of as energy intermediaries in the intracellular space, these nucleotides primarily act as signaling molecules in the extracellular space.
Hyman, Matthew Craig
core
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas [PDF]
, 1998 Ecto-ATPase activities of melanocytes and human melanoma cell lines differing in the stage of progression were compared. A dramatic increase in ecto-ATPase activity above the level of normal melanocytes was demonstrated in the differentiated melanomas ...
Dzhandzhugazyan, Karine N +7 more
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Pain Practice, Volume 26, Issue 7, September 2026.ABSTRACT Background Several studies point towards the involvement of the immune system (especially the monocyte–macrophage system) in the pathophysiology of Complex Regional Pain Syndrome (CRPS), as shown by increased levels of the cytokines tumor necrosis factor (TNF)‐α and interleukin (IL)‐6.
Nadia Kriek +6 more
wiley +1 more source
Cancer, Volume 132, Issue 15, 1 August 2026.Abstract In the past 15 years, immunotherapy has become a major strategy for cancer therapy. Tumor‐infiltrating lymphocyte (TIL) therapy has been under investigation for nearly four decades and received its first Food and Drug Administration approval in 2024, when lifileucel was approved for patients with previously treated metastatic melanoma.
Shen Li +5 more
wiley +1 more source
Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens [PDF]
, 2016 SummaryIn humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood.
Idzko, Marco +11 more
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Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show limited response to standard therapies, emphasizing the need for novel, safe, and more effective targeted ...
Rongrong Hu, Zaker Ataullev, Luping Lou
wiley +1 more source
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors [PDF]
, 2022 Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP to yield AMP. AMP is subsequently
Bi, Chunyang
core
Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals
Cell Reports, 2016 Summary: In an immune response, CD4+ T cells expand into effector T cells and then contract to survive as long-lived memory cells. To identify age-associated defects in memory cell formation, we profiled activated CD4+ T cells and found an increased ...
Fengqin Fang +12 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4761-4777, August 2026.Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin +10 more
wiley +1 more source