Results 131 to 140 of about 31,390 (228)

CD39 EXPRESSION MODULATES ISCHEMIA INDUCED DIASTOLIC DYSFUNCTION [PDF]

, 2012
CD39 EXPRESSION MODULATES ISCHEMIA INDUCED DIASTOLIC ...
Anthony JF d'Apice (14541305), Debra G Wheeler (13612282), Richard J Gumina (13355988), Sibel Gokce (19214131), Shouvik D Mahamud (13612690), Zhaobin Xu (381351), Karen M Dwyer (14541281), Simon C Robson (13355982), Peter J Cowan (13355985)   +8 more
core  

Cancer immunotherapy by adenosinergic CD39 and CD73 as emerging immune checkpoints

Discover Oncology
Extracellular adenosine has recently been identified as an immunological checkpoint mediator that hinders the immune response to malignancies. The production of adenosine is facilitated by the enzymatic activity of CD39 and CD73.
Xinyu Yin, Ying Yang, Songjiang Liu
doaj   +1 more source

Regulatory role of CD39 and CD73 in tumor immunity

Future Oncology
CD39 is the rate-limiting enzyme for the molecular signal cascade leading to the generation of ADP and adenosine monophosphate (AMP). In conjunction with CD73, CD39 converts adenosine triphosphate (ATP) to ADP and AMP, which leads to the accumulation of immunosuppressive adenosine in the tumor microenvironment.
Nicole Kaplinsky, Kada Williams, Dean Watkins, Molly Adams, Laura Stanbery, John Nemunaitis   +5 more
openaire   +2 more sources

CD39+CD8+ T cell infiltration is associated with clinical outcomes of subsequent immunotherapy in advanced EGFR-mutant non-small cell lung cancer

Therapeutic Advances in Medical Oncology
Background: Immunotherapy has demonstrated limited efficacy in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), often due to an immunosuppressive tumor microenvironment (TME).
Wanjun Lu, Qiuxia Wu, Zimu Wang, Qinpei Cheng, Xueying Zuo, Xin Liu, Jiawen Lv, Yong Song, Fang Zhang, Tangfeng Lv   +9 more
doaj   +1 more source

The vascular ectonucleotidase CD39 is permissive for sinusoidal endothelial cell proliferation during liver regeneration: evidence for synergism between growth factors and extracellular nucleotides [PDF]

, 2007
Crosstalk between elements of the sinusoidal vasculature, platelets and hepatic parenchymal cells influences regenerative responses to liver injury and/or resection. Such paracrine interactions include hepatocyte growth factor (HGF), vascular endothelial
Sun, XF, Beldi, Guido, Enjyoji, Keiichi, Zimmermann, H, Imai, M, Imai, Masato, Yan, Wu, Candinas, Daniel, Enjyoji, K, Sun, Xiaofeng, Zimmermann, Herbert, Robson, Simon C, Wu, Y, Beldi, G, Candinas, D   +14 more
core  

Overexpression of CD39 protects in a mouse model of preeclampsia [PDF]

, 2013
CD39 (NTPDase1), a critical immune and vascular ecto-nucleotidase, hydrolyses pro-inflammatory and pro-thrombotic nucleotides (adenosine-5'-triphosphate (ATP) and adenosine diphosphate) to adenosine.
Joanne Sj Chia (13612720), Jennifer L McRae (13589077), Karen M Dwyer (14541281), Prudence A Russell (13612717)   +3 more
core  

Identification of clinically relevant subsets CD39+PD-1+CD8+ T cells and CD39+ regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF [PDF]

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy with limited treatment options and a dismal prognosis. The tumor immune microenvironment (TIME) is crucial for iCCA progression, yet its comprehensive characterization remains ...
Qi-Wei Zhang, Meng-Xuan Zhu, Bin-Bin Liu, Yong-Sheng Jiang, Wei-Wei Rui, Wen-Feng Liu, Xiao-Yi Ding, Zhi-Yuan Wu, Yong Chen   +8 more
core   +1 more source

T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis

International Journal of Nanomedicine
Xiaoshan Yang,1– 3,* Yang Zhou,2,3,* Fuxing Zhou,4,* Lili Bao,2,3 Zhengyan Wang,5 Zihan Li,2,3 Feng Ding,2,3 Huijuan Kuang,6,7 Huan Liu,8 Shenglong Tan,1 Xinyuan Qiu,1 Huan Jing,9 Shiyu Liu,2,3 Dandan Ma1 1Department of Endodontics ...
Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D   +13 more
doaj  

Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle-invasive bladder cancer. [PDF]

J Pathol Clin Res
Ledderose S, Schwenke J, Eismann L, Rodler S, Rudelius M, Ledderose C.   +5 more
europepmc   +1 more source

CD39 mRNA therapy attenuates localized acute inflammation: A novel anti-inflammatory strategy using cationic nanoliposomes. [PDF]

Mol Ther Nucleic Acids
Philosof NR, Walsh APG, Xu B, Watson AMD, Ren S, Hann L, Nathaniel B, Nguyen A, Liu H, Shi P, Bongcaron V, Nguyen H, Noonan J, Avci-Adali M, Peter K, Vidallon MLP, Wang X.   +16 more
europepmc   +1 more source