Results 1 to 10 of about 39,639 (239)

Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation

Journal for ImmunoTherapy of Cancer, 2023
Background Irradiation (IR) and immune checkpoint inhibitor (ICI) combination is a promising treatment modality. However, local and distance treatment failure and resistance can occur.
Pierre-Antoine Laurent, Eric Deutsch, Michele Mondini, Marine Gerbé De Thoré, Winchygn Liu, Lydia Meziani, Céline Clémenson, Marie-Catherine Vozenin   +7 more
doaj   +2 more sources

CD73 is associated with glycolysis related metabolic programs and CD8+ T cell suppression in pancreatic ductal adenocarcinoma [PDF]

Frontiers in Immunology
CD73 is an enzyme that generates extracellular adenosine and has been implicated in tumor-associated immune suppression, but its biological and clinical significance in pancreatic ductal adenocarcinoma (PDAC) remains incompletely understood.
Eriko Katsuta, Aarohan Mukherjee Burma, Eito Nakagawa, Ken Oh, Tao Dai, Subhamoy Dasgupta, Kazuaki Takabe, Kazuaki Takabe, Daisuke Ban   +8 more
doaj   +2 more sources

CD73, a Promising Therapeutic Target of Diclofenac, Promotes Metastasis of Pancreatic Cancer through a Nucleotidase Independent Mechanism

Advanced Science, 2023
CD73, a cell surface‐bound nucleotidase, facilitates extracellular adenosine formation by hydrolyzing 5′‐AMP to adenosine. Several studies have shown that CD73 plays an essential role in immune escape, cell proliferation and tumor angiogenesis, making it
Antão Chang, Chongbiao Huang, Xiaozhou Yu   +2 more
exaly   +2 more sources

Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia [PDF]

ImmunoAnalysis, 2022
Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while ...
Mohammad Sadeghi, Mahsa Yousefi Bostanabad, Omid Abedi, Abbas Ali Hosseinpour Feizi, Ali Akbar Movasaghpour Akbari, Farhad Jadidi-Niaragh   +5 more
doaj   +1 more source

Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML

OncoImmunology, 2021
The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (AML ...
F. Brauneck, F Haag, R. Woost, N. Wildner, E. Tolosa, A. Rissiek, G. Vohwinkel, J. Wellbrock, C. Bokemeyer, J. Schulze zur Wiesch, C. Ackermann, W. Fiedler   +11 more
doaj   +1 more source

Assessment of CD4⁺ cells subpopulations with the expressing CD39 and CD73 ectonucleotidases in children with psoriasis

Медицинская иммунология, 2022
Purinergic signaling modulates systemic and local inflammatory responses in immune-mediated and autoimmune diseases, including psoriasis. Extracellular ATP is an important factor of purinergic regulation, and its levels are regulated by catalytic effects
D. G. Kuptsova, T. V. Radigina, S. V. Petrichuk, N. N. Murashkin, A. A. Khotko, R. A. Ivanov   +5 more
doaj   +1 more source

Unlocking new frontiers: novel immune targets for next-generation cancer immunotherapy [PDF]

Korean Journal of Clinical Oncology
Cancer immunotherapy represents a transformative strategy in modern oncology, utilizing the body’s immune system to recognize and eliminate malignant cells with precision. Unlike traditional therapies, which often directly target the tumor, immunotherapy
Sufian Zaheer, Niti Sureka
doaj   +1 more source

CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent MannerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Metabolic imbalance and inflammation are common features of chronic liver diseases. Molecular factors controlling these mechanisms represent potential therapeutic targets.
Karel P. Alcedo, Morgan A. Rouse, Gloria S. Jung, Dong Fu, Marquet Minor, Helen H. Willcockson, Kevin G. Greene, Natasha T. Snider   +7 more
doaj   +1 more source

Development of aortic endothelial cells to express CD37 and CD73 isolated from alpha 1,3-galactosyltransferase knock-out and MCP expressing pig

Journal of Animal Reproduction and Biotechnology, 2018
Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No, Sung-June Byun, Hyeon Yang, Sun A Ock, Jae-Seok Woo, Hwi-Cheul Lee, In-sul Hwang, Ji-Youn Kim, Sang Hyoun Park, Joo Young Lee, Keon Bong Oh   +10 more
doaj   +1 more source

Graft-versus-host disease is enhanced by selective CD73 blockade in mice. [PDF]

PLoS ONE, 2013
CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models.
Long Wang, Jie Fan, Siqi Chen, Yi Zhang, Tyler J Curiel, Bin Zhang   +5 more
doaj   +1 more source