Results 1 to 10 of about 38,724 (265)

CD73-Deficient Mice Are Resistant to Carcinogenesis [PDF]

Cancer Research, 2012
Abstract CD73 is a cell surface 5′-nucleotidase that converts AMP to adenosine, an immune suppressive molecule. CD73 may promote immune escape in cancer by contributing to the degradation of extracellular ATP released by dying cancer cells in hypoxic tumors or following chemotherapy.
Stagg, John, Beavis, Paul A., Divisekera, Upulie, Liu, Mira C. P., Möller, Andreas, Darcy, Phillip K., Smyth, Mark J.   +6 more
openaire   +6 more sources

An Exceptionally Potent Inhibitor of Human CD73 [PDF]

Biochemistry, 2019
We recently reported the initiation of a Phase I clinical trial with AB680, a potent human CD73 inhibitor, being developed for the treatment of solid tumors (NCT03677973). We undertook a detailed kinetic analysis of the interaction between human CD73 and AB680 to determine the mode of inhibition.
Christine E. Bowman, Rafael G. da Silva, Amber Pham, Stephen W. Young   +3 more
openaire   +5 more sources

Features of parameters of cellular immune depending on the activity of foci of demyelination in children with multiple sclerosis

Медицинская иммунология, 2023
MS is a common disease of the central nervous system that leads to disability and reduced quality of life. The debut of disease in 3-5% of patients occurs in childhood and has a less favorable course compared to adults.
T. V. Radygina, D. G. Kuptsova, O. V. Kurbatova, S. V. Petrichuk, E. L. Semikina, A. P. Fisenko, L. M. Abdullaeva, B. I. Bursagova   +7 more
doaj   +1 more source

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases

OncoImmunology, 2017
The emerging role for CD73 in driving cancer growth and metastasis has presented opportunities to develop anti-CD73 monoclonal antibodies (mAbs) in the treatment of human cancers.
Dipti Vijayan, Deborah S. Barkauskas, Kimberley Stannard, Erin Sult, Rebecca Buonpane, Kazuyoshi Takeda, Michele W. L. Teng, Kris Sachsenmeier, Carl Hay, Mark J. Smyth   +9 more
doaj   +1 more source

Determination of CD39 and CD73 expression together with their serum soluble levels in bronchial asthma [PDF]

Exploration of Immunology
Aim: This study aimed to evaluate the expression of ectonucleotidases cluster of differentiation 39 (ecto-adenosine triphosphate diphosphohydrolase) (CD39) and cluster of differentiation 73 (ecto-5’-nucleotidase) (CD73) and determine the serum levels of ...
Amany G. Thabit, Wegdan Elagan, Noha N. Tawifilis, Yousra Ezzat   +3 more
doaj   +1 more source

CD73 sustained cancer-stem-cell traits by promoting SOX9 expression and stability in hepatocellular carcinoma

Journal of Hematology & Oncology, 2020
Background Aberrant AKT activation contributes to cancer stem cell (CSC) traits in hepatocellular carcinoma (HCC). We previously reported that CD73 activated AKT signaling via the Rap1/P110β cascade.
Xiao-Lu Ma, Bo Hu, Wei-Guo Tang, Su-Hong Xie, Ning Ren, Lin Guo, Ren-Quan Lu   +6 more
doaj   +1 more source

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer

OncoImmunology, 2017
CD39/CD73-adenosine pathway has been recently defined as an important tumor-induced immunosuppressive mechanism. We here documented a fraction of CD11b+CD33+ myeloid-derived suppressor cells (MDSCs) in peripheral blood and tumor tissues from non-small ...
Jieyao Li, Liping Wang, Xinfeng Chen, Lifeng Li, Yu Li, Yu Ping, Lan Huang, Dongli Yue, Zhen Zhang, Fei Wang, Feng Li, Li Yang, Jianmin Huang, Shuangning Yang, Hong Li, Xuan Zhao, Wenjie Dong, Yan Yan, Song Zhao, Bo Huang, Bin Zhang, Yi Zhang   +21 more
doaj   +1 more source

Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy

Cancer Biology & Medicine
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages (TAMs), a key determinant of the tumor microenvironment (TME).
Lei Yang, Yi Zhang, Li Yang
doaj   +1 more source

Serum 5′-Nucleotidase as a Novel Predictor of Adverse Clinical Outcomes after Percutaneous Coronary Intervention in Patients with Coronary Artery Disease

Reviews in Cardiovascular Medicine
Background: The correlation between 5′-Nucleotidase (5′-NT) and the clinical outcomes in coronary artery disease (CAD) patients following percutaneous coronary intervention (PCI) is not clear. This study aims to clarify this relationship.
Mikereyi Aimaitijiang, Ting-Ting Wu, Ying-Ying Zheng, Xian-Geng Hou, Haitao Yang, Yi Yang, Xiang Xie   +6 more
doaj   +1 more source

CD73 Severed as a Potential Prognostic Marker and Promote Lung Cancer Cells Migration via Enhancing EMT Progression

Frontiers in Genetics, 2021
To investigate the expression levels and prognostic value of CD73 in lung cancer. And moreover, to identify the effect and potential mechanism of CD73 on lung cancer cells proliferation and migration.
Zhao-wei Gao, Chong Liu, Lan Yang, Hao-chuan Chen, Long-fei Yang, Hui-zhong Zhang, Ke Dong   +6 more
doaj   +1 more source