Results 11 to 20 of about 36,605 (250)
CD73 Activity is Dispensable for the Polarization of M2 Macrophages. [PDF]
PLoS ONE, 2015 The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine. On regulatory T cells, CD73 is necessary for immunosuppressive functions, and on Th17 cells CD73-generated adenosine exerts anti ...
Dominik Eichin +3 more
doaj +6 more sources
CD73 Promotes Chronic Lymphocytic Leukemia [PDF]
Cancers, 2022 The ecto-nucleotidase CD73 is an important immune checkpoint in tumor immunity that cooperates with CD39 to hydrolyze pro-inflammatory extracellular ATP into immunosuppressive adenosine. While the role of CD73 in immune evasion of solid cancers is well established, its role in leukemia remains unclear.
David Allard +7 more
openaire +3 more sources
CD73-Deficient Mice Are Resistant to Carcinogenesis [PDF]
Cancer Research, 2012 Abstract CD73 is a cell surface 5′-nucleotidase that converts AMP to adenosine, an immune suppressive molecule. CD73 may promote immune escape in cancer by contributing to the degradation of extracellular ATP released by dying cancer cells in hypoxic tumors or following chemotherapy.
Stagg, John +6 more
openaire +7 more sources
CD73 in Autoimmune Arthritis [PDF]
Receptors & Clinical Investigation, 2015 Abstract Adenosine is a potent anti-inflammatory molecule that plays an important role in many diseases. Extracellular levels of adenosine are determined by a combination of membrane transporters and ecto-nucleotidases such as CD73. Therapeutic targeting of the adenosinergic pathway, such as administration of adenosine receptor agonists, could be a ...
Pavel Chrobak, John Stagg
openaire +3 more sources
CD73, a significant protein in liver diseases [PDF]
Frontiers in Medicine, 2023 Purine adenosine pathway exists widely in the body metabolism, and is involved in regulating various physiological processes. It is one of the important pathways of environmental regulation in human body. CD73 is essentially a protease that catalyzes further dephosphorylation of extracellular adenine nucleotides, hydrolyzing extracellular AMP to ...
Huilian Shi +4 more
openaire +5 more sources
An Exceptionally Potent Inhibitor of Human CD73 [PDF]
Biochemistry, 2019 We recently reported the initiation of a Phase I clinical trial with AB680, a potent human CD73 inhibitor, being developed for the treatment of solid tumors (NCT03677973). We undertook a detailed kinetic analysis of the interaction between human CD73 and AB680 to determine the mode of inhibition.
Christine E. Bowman +3 more
openaire +6 more sources
The CD73 immune checkpoint promotes tumor cell metabolic fitness [PDF]
eLife, 2023 CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials.
David Allard +6 more
doaj +2 more sources
PET imaging of colon cancer CD73 expression using cysteine site-specific 89Zr-labeled anti-CD73 antibody [PDF]
Scientific ReportsCD73 is a cell-surface ectoenzyme that hydrolyzes the conversion of extracellular adenosine monophosphate to adenosine, which in turn can promote resistance to immune checkpoint blockade therapy.
Kyung-Ho Jung +6 more
doaj +2 more sources
CD73 Dysregulates Monocyte Anti-Tumor Activity in Multiple Myeloma [PDF]
Cancer Management and Research, 2023 Lin Zhou,1,* XiaoLan Liu,2,* Tao Guan,2 HaiLing Xu,1 Fang Wei1 1Department of Hematology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Shanxi Key Laboratory of Precise and Diagnosis and Therapy of
Zhou L, Liu X, Guan T, Xu H, Wei F
doaj +1 more source
Advanced Science, 2023 CD73, a cell surface‐bound nucleotidase, facilitates extracellular adenosine formation by hydrolyzing 5′‐AMP to adenosine. Several studies have shown that CD73 plays an essential role in immune escape, cell proliferation and tumor angiogenesis, making it
Antão Chang
exaly +2 more sources