Results 11 to 20 of about 39,639 (239)
Scientific ReportsCD73 is a cell-surface ectoenzyme that hydrolyzes the conversion of extracellular adenosine monophosphate to adenosine, which in turn can promote resistance to immune checkpoint blockade therapy.
Kyung-Ho Jung +6 more
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CD73 in Autoimmune Arthritis [PDF]
Receptors & Clinical Investigation, 2015 Abstract Adenosine is a potent anti-inflammatory molecule that plays an important role in many diseases. Extracellular levels of adenosine are determined by a combination of membrane transporters and ecto-nucleotidases such as CD73. Therapeutic targeting of the adenosinergic pathway, such as administration of adenosine receptor agonists, could be a ...
Pavel Chrobak, John Stagg
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CD73 Dysregulates Monocyte Anti-Tumor Activity in Multiple Myeloma
Cancer Management and Research, 2023 Lin Zhou,1,* XiaoLan Liu,2,* Tao Guan,2 HaiLing Xu,1 Fang Wei1 1Department of Hematology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Shanxi Key Laboratory of Precise and Diagnosis and Therapy of
Zhou L, Liu X, Guan T, Xu H, Wei F
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CD73-Deficient Mice Are Resistant to Carcinogenesis [PDF]
Cancer Research, 2012 Abstract CD73 is a cell surface 5′-nucleotidase that converts AMP to adenosine, an immune suppressive molecule. CD73 may promote immune escape in cancer by contributing to the degradation of extracellular ATP released by dying cancer cells in hypoxic tumors or following chemotherapy.
Stagg, John +6 more
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CD73+ Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice [PDF]
Frontiers in Immunology, 2020 Previous studies have shown that CD73 is pivotal in the conversion of pro-inflammatory adenosine triphosphate into anti-inflammatory adenosine and that immune cells of the same type that express different levels of CD73 are functionally distinct. In this
MinHee K. Ko +3 more
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npj Regenerative MedicineNeurogenic bladder (NB) is a disabling condition lacking effective therapies. This study investigated whether CD73-expressing adipose-derived stem cells (ADSCs) promote bladder repair in a rat model of NB and explored the underlying mechanisms.
Guanqun Zhu +10 more
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, 2023 5′-Ectonucleotidase (e5NT), a metalloenzyme also known as CD73, hydrolyzes AMP to phosphate and adenosine. In mammalians, CD73 is involved in several physiological and pathological processes, among which immune homeostasis, inflammation, and tumor progression.
Supuran C. T., Capasso C.
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CD73 Activity is Dispensable for the Polarization of M2 Macrophages.
PLoS ONE, 2015 The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine. On regulatory T cells, CD73 is necessary for immunosuppressive functions, and on Th17 cells CD73-generated adenosine exerts anti ...
Dominik Eichin +3 more
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BISPECIFIC ANTIBODIES TARGETING HUMAN CD73
, 2017 The present invention relates to a bispecific antibody targeting CD73. In particular, the present invention relates to a bispecific antibody targeting different epitopes on CD73 or a bispecific antibody targeting an epitope on CD73 and an epitope on a different antigen.
Ditzel, Henrik, Gammelgaard, Odd Lilleng
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Research Progress of CD73 in Cancer [PDF]
, 2023 CD73 (NT5E, extracellular 5' nucleotidase) is a multifunctional glycoprotein encoded by the NT5E gene with a relative molecular weight of 70 kD that can be anchored to the outer surface of cell membranes by glycosyl phosphatidylinositol (GPI).CD73 ...
Guo, Shuang, Liu, Hongli
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