Results 11 to 20 of about 51,093 (261)
Scientific ReportsCD73 is a cell-surface ectoenzyme that hydrolyzes the conversion of extracellular adenosine monophosphate to adenosine, which in turn can promote resistance to immune checkpoint blockade therapy.
Kyung-Ho Jung +6 more
doaj +3 more sources
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes [PDF]
Cells, 2020 The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19.
Parimah Ahmadi +9 more
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CD73 Promotes Chronic Lymphocytic Leukemia
Cancers, 2022 The ecto-nucleotidase CD73 is an important immune checkpoint in tumor immunity that cooperates with CD39 to hydrolyze pro-inflammatory extracellular ATP into immunosuppressive adenosine. While the role of CD73 in immune evasion of solid cancers is well established, its role in leukemia remains unclear.
David Allard +7 more
openaire +2 more sources
Медицинская иммунология, 2022 Purinergic signaling modulates systemic and local inflammatory responses in immune-mediated and autoimmune diseases, including psoriasis. Extracellular ATP is an important factor of purinergic regulation, and its levels are regulated by catalytic effects
D. G. Kuptsova +5 more
doaj +1 more source
Host CD73 impairs anti-tumor immunity [PDF]
OncoImmunology, 2012 The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for
Salmi, Marko, Jalkanen, Sirpa
openaire +4 more sources
Journal for ImmunoTherapy of Cancer, 2023 Background Irradiation (IR) and immune checkpoint inhibitor (ICI) combination is a promising treatment modality. However, local and distance treatment failure and resistance can occur.
Pierre-Antoine Laurent +7 more
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CD73‐generated adenosine promotes osteoblast differentiation [PDF]
Journal of Cellular Physiology, 2012 AbstractCD731 is a GPI‐anchored cell surface protein with ecto‐5′‐nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73‐generated adenosine in bone tissue are largely unknown. To address this
Masahide, Takedachi +11 more
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Fluorescent Probes for Ecto-5′-nucleotidase (CD73) [PDF]
ACS Medicinal Chemistry Letters, 2020 Ecto-5'-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an immunosuppressive microenvironment.
Constanze C. Schmies +12 more
openaire +3 more sources
Unlocking new frontiers: novel immune targets for next-generation cancer immunotherapy [PDF]
Korean Journal of Clinical OncologyCancer immunotherapy represents a transformative strategy in modern oncology, utilizing the body’s immune system to recognize and eliminate malignant cells with precision. Unlike traditional therapies, which often directly target the tumor, immunotherapy
Sufian Zaheer, Niti Sureka
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Metabolic imbalance and inflammation are common features of chronic liver diseases. Molecular factors controlling these mechanisms represent potential therapeutic targets.
Karel P. Alcedo +7 more
doaj +1 more source