Results 21 to 30 of about 36,481 (278)

The Roles of CD73 in Cancer

BioMed Research International, 2014
Purinergic signaling has emerged as an important player in cancer progression and is regulated by a series of nucleotidases. Among the enzyme cascade, CD73, which catelyzes AMP breakdown to adenosine, has been found to be overexpressed in many types of cancer. Various factors and mechanisms are employed to regulate expression of CD73.
Gao, Zhao-wei, Dong, Ke, Zhang, Hui-zhong   +2 more
openaire   +3 more sources

Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation

Journal for ImmunoTherapy of Cancer, 2023
Background Irradiation (IR) and immune checkpoint inhibitor (ICI) combination is a promising treatment modality. However, local and distance treatment failure and resistance can occur.
Pierre-Antoine Laurent, Eric Deutsch, Michele Mondini, Marine Gerbé De Thoré, Winchygn Liu, Lydia Meziani, Céline Clémenson, Marie-Catherine Vozenin   +7 more
doaj   +1 more source

Unlocking new frontiers: novel immune targets for next-generation cancer immunotherapy [PDF]

Korean Journal of Clinical Oncology
Cancer immunotherapy represents a transformative strategy in modern oncology, utilizing the body’s immune system to recognize and eliminate malignant cells with precision. Unlike traditional therapies, which often directly target the tumor, immunotherapy
Sufian Zaheer, Niti Sureka
doaj   +1 more source

CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent MannerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Metabolic imbalance and inflammation are common features of chronic liver diseases. Molecular factors controlling these mechanisms represent potential therapeutic targets.
Karel P. Alcedo, Morgan A. Rouse, Gloria S. Jung, Dong Fu, Marquet Minor, Helen H. Willcockson, Kevin G. Greene, Natasha T. Snider   +7 more
doaj   +1 more source

CD73: Friend or Foe in Lung Injury

International Journal of Molecular Sciences, 2023
Ecto-5′-nucleotidase (CD73) plays a strategic role in calibrating the magnitude and chemical nature of purinergic signals that are delivered to immune cells. Its primary function is to convert extracellular ATP to adenosine in concert with ectonucleoside triphosphate diphosphohydrolase-1 (CD39) in normal tissues to limit an excessive immune response in
Hu, Xiu-Min, Shi, Nan-Rui, Zhang, Ji-Zhou, Zuo, Yan-Qin, Wang, Xin, Zhao, Ya-Fei, Wu, Jia-Si   +6 more
openaire   +2 more sources

Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]

, 2003
In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Kempkes, B., W. Gutensohn, Napieralski, R., Gutensohn, W., R. Napieralski, B. Kempkes   +5 more
core   +1 more source

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity [PDF]

, 2012
Background:Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers.
Monteverde, M, K Purdie, P Szlosarek, Fleming, C, Thompson, A, Szlosarek, P., Crook, T., Lo Nigro, C., M Merlano, Fleming, C., Purdie, K., Lattanzio, L., Proby, C., Inman, G. J., C Harwood, I Leigh, Lee, S, D Bergamaschi, Evans, A, C Lo Nigro, McHugh, A, E Hatzimichael, C Fleming, E Briasoulis, McHugh, A., Briasoulis, E, A McHugh, A Thompson, H Wang, N Syed, Szlosarek, P, Briasoulis, E., Inman, GJ, Monteverde, M., Matin, R, S Lee, M Monteverde, Thompson, A., N Mladkova, Proby, C, A Evans, G J Inman, Syed, N, Wang, H., Lee, S., Bergamaschi, D., L Lattanzio, Wang, H, Crook, Tim, Leigh, I, Nigro, C. Lo, R Matin, T Crook, Evans, A., Crook, T, Purdie, K, Merlano, M, Bergamaschi, D, Leigh, I., Lattanzio, L, Mladkova, N, Lo Nigro, C, Inman, G.J., Mladkova, N., Merlano, M., Hatzimichael, E., Hatzimichael, E, Harwood, C., Syed, N., Matin, R., Harwood, C, C Proby   +71 more
core   +1 more source

CD73: A Key Player in HIV Persistence [PDF]

, 2021
Replication of human immunodeficiency virus (HIV) is suppressed to undetectable levels by effective antiretroviral therapy (ART). However, current therapeutic regimens fail to completely eradicate HIV due to the persistence of latently-infected cells ...
Sperber, Hannah Sabeth
core   +1 more source

Graft-versus-host disease is enhanced by selective CD73 blockade in mice. [PDF]

PLoS ONE, 2013
CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models.
Long Wang, Jie Fan, Siqi Chen, Yi Zhang, Tyler J Curiel, Bin Zhang   +5 more
doaj   +1 more source

Development of aortic endothelial cells to express CD37 and CD73 isolated from alpha 1,3-galactosyltransferase knock-out and MCP expressing pig

Journal of Animal Reproduction and Biotechnology, 2018
Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No, Sung-June Byun, Hyeon Yang, Sun A Ock, Jae-Seok Woo, Hwi-Cheul Lee, In-sul Hwang, Ji-Youn Kim, Sang Hyoun Park, Joo Young Lee, Keon Bong Oh   +10 more
doaj   +1 more source