Results 21 to 30 of about 38,724 (265)

Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia [PDF]

ImmunoAnalysis, 2022
Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while ...
Mohammad Sadeghi, Mahsa Yousefi Bostanabad, Omid Abedi, Abbas Ali Hosseinpour Feizi, Ali Akbar Movasaghpour Akbari, Farhad Jadidi-Niaragh   +5 more
doaj   +1 more source

Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML

OncoImmunology, 2021
The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (AML ...
F. Brauneck, F Haag, R. Woost, N. Wildner, E. Tolosa, A. Rissiek, G. Vohwinkel, J. Wellbrock, C. Bokemeyer, J. Schulze zur Wiesch, C. Ackermann, W. Fiedler   +11 more
doaj   +1 more source

Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation

Journal for ImmunoTherapy of Cancer, 2023
Background Irradiation (IR) and immune checkpoint inhibitor (ICI) combination is a promising treatment modality. However, local and distance treatment failure and resistance can occur.
Pierre-Antoine Laurent, Eric Deutsch, Michele Mondini, Marine Gerbé De Thoré, Winchygn Liu, Lydia Meziani, Céline Clémenson, Marie-Catherine Vozenin   +7 more
doaj   +1 more source

Research Progress of CD73 in Cancer [PDF]

, 2023
CD73 (NT5E, extracellular 5' nucleotidase) is a multifunctional glycoprotein encoded by the NT5E gene with a relative molecular weight of 70 kD that can be anchored to the outer surface of cell membranes by glycosyl phosphatidylinositol (GPI).CD73 ...
Guo, Shuang, Liu, Hongli
core   +1 more source

Assessment of CD4⁺ cells subpopulations with the expressing CD39 and CD73 ectonucleotidases in children with psoriasis

Медицинская иммунология, 2022
Purinergic signaling modulates systemic and local inflammatory responses in immune-mediated and autoimmune diseases, including psoriasis. Extracellular ATP is an important factor of purinergic regulation, and its levels are regulated by catalytic effects
D. G. Kuptsova, T. V. Radigina, S. V. Petrichuk, N. N. Murashkin, A. A. Khotko, R. A. Ivanov   +5 more
doaj   +1 more source

Unlocking new frontiers: novel immune targets for next-generation cancer immunotherapy [PDF]

Korean Journal of Clinical Oncology
Cancer immunotherapy represents a transformative strategy in modern oncology, utilizing the body’s immune system to recognize and eliminate malignant cells with precision. Unlike traditional therapies, which often directly target the tumor, immunotherapy
Sufian Zaheer, Niti Sureka
doaj   +1 more source

Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]

, 2003
In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Kempkes, B., W. Gutensohn, Napieralski, R., Gutensohn, W., R. Napieralski, B. Kempkes   +5 more
core   +1 more source

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity [PDF]

, 2012
Background:Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers.
Monteverde, M, K Purdie, P Szlosarek, Fleming, C, Thompson, A, Szlosarek, P., Crook, T., Lo Nigro, C., M Merlano, Fleming, C., Purdie, K., Lattanzio, L., Proby, C., Inman, G. J., C Harwood, I Leigh, Lee, S, D Bergamaschi, Evans, A, C Lo Nigro, McHugh, A, E Hatzimichael, C Fleming, E Briasoulis, McHugh, A., Briasoulis, E, A McHugh, A Thompson, H Wang, N Syed, Szlosarek, P, Briasoulis, E., Inman, GJ, Monteverde, M., Matin, R, S Lee, M Monteverde, Thompson, A., N Mladkova, Proby, C, A Evans, G J Inman, Syed, N, Wang, H., Lee, S., Bergamaschi, D., L Lattanzio, Wang, H, Crook, Tim, Leigh, I, Nigro, C. Lo, R Matin, T Crook, Evans, A., Crook, T, Purdie, K, Merlano, M, Bergamaschi, D, Leigh, I., Lattanzio, L, Mladkova, N, Lo Nigro, C, Inman, G.J., Mladkova, N., Merlano, M., Hatzimichael, E., Hatzimichael, E, Harwood, C., Syed, N., Matin, R., Harwood, C, C Proby   +71 more
core   +1 more source

CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent MannerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Metabolic imbalance and inflammation are common features of chronic liver diseases. Molecular factors controlling these mechanisms represent potential therapeutic targets.
Karel P. Alcedo, Morgan A. Rouse, Gloria S. Jung, Dong Fu, Marquet Minor, Helen H. Willcockson, Kevin G. Greene, Natasha T. Snider   +7 more
doaj   +1 more source

CD73: A Key Player in HIV Persistence [PDF]

, 2021
Replication of human immunodeficiency virus (HIV) is suppressed to undetectable levels by effective antiretroviral therapy (ART). However, current therapeutic regimens fail to completely eradicate HIV due to the persistence of latently-infected cells ...
Sperber, Hannah Sabeth
core   +1 more source