Results 21 to 30 of about 39,639 (239)

Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]

, 2003
In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Kempkes, B., W. Gutensohn, Napieralski, R., Gutensohn, W., R. Napieralski, B. Kempkes   +5 more
core   +1 more source

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity [PDF]

, 2012
Background:Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers.
Monteverde, M, K Purdie, P Szlosarek, Fleming, C, Thompson, A, Szlosarek, P., Crook, T., Lo Nigro, C., M Merlano, Fleming, C., Purdie, K., Lattanzio, L., Proby, C., Inman, G. J., C Harwood, I Leigh, Lee, S, D Bergamaschi, Evans, A, C Lo Nigro, McHugh, A, E Hatzimichael, C Fleming, E Briasoulis, McHugh, A., Briasoulis, E, A McHugh, A Thompson, H Wang, N Syed, Szlosarek, P, Briasoulis, E., Inman, GJ, Monteverde, M., Matin, R, S Lee, M Monteverde, Thompson, A., N Mladkova, Proby, C, A Evans, G J Inman, Syed, N, Wang, H., Lee, S., Bergamaschi, D., L Lattanzio, Wang, H, Crook, Tim, Leigh, I, Nigro, C. Lo, R Matin, T Crook, Evans, A., Crook, T, Purdie, K, Merlano, M, Bergamaschi, D, Leigh, I., Lattanzio, L, Mladkova, N, Lo Nigro, C, Inman, G.J., Mladkova, N., Merlano, M., Hatzimichael, E., Hatzimichael, E, Harwood, C., Syed, N., Matin, R., Harwood, C, C Proby   +71 more
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

The Roles of CD73 in Cancer

BioMed Research International, 2014
Purinergic signaling has emerged as an important player in cancer progression and is regulated by a series of nucleotidases. Among the enzyme cascade, CD73, which catelyzes AMP breakdown to adenosine, has been found to be overexpressed in many types of cancer. Various factors and mechanisms are employed to regulate expression of CD73.
Gao, Zhao-wei, Dong, Ke, Zhang, Hui-zhong   +2 more
openaire   +3 more sources

CD73 Promotes Chronic Lymphocytic Leukemia

, 2022
SIMPLE SUMMARY: Many patients with chronic lymphocytic leukemia (CLL) still fail current therapies. CD73 is a novel therapeutic target for solid tumors, but its role in CLL remains unclear.
Allard, David, Bertrand Allard, Allard, Bertrand, Tessier, Priscilla, Nathalie A. Johnson, Pavel Chrobak, Bergeron, Marjorie A., Stagg, John, David Allard, Marjorie A. Bergeron, Johnson, Nathalie A., Bareche, Yacine, Priscilla Tessier, Chrobak, Pavel, John Stagg, Yacine Bareche   +15 more
core   +1 more source

The CD73 immune checkpoint promotes tumor cell metabolic fitness

eLife, 2023
CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials.
David Allard, Isabelle Cousineau, Eric H Ma, Bertrand Allard, Yacine Bareche, Hubert Fleury, John Stagg   +6 more
doaj   +1 more source

Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2023
Background CD73 promotes progression in several malignancies and is considered as a novel immune checkpoint. However, the function of CD73 in intrahepatic cholangiocarcinoma (ICC) remains uncertain.
Bao-Ye Sun, Zhang-Fu Yang, Zhu-Tao Wang, Gao Liu, Cheng Zhou, Jian Zhou, Jia Fan, Wei Gan, Yong Yi, Shuang-Jian Qiu   +9 more
doaj   +1 more source

PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment

Molecular & Cellular Oncology, 2017
The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells.
Ya-Ting Wang, Ruey-Hwa Chen
doaj   +1 more source

CD39 and CD73 in immunity and inflammation [PDF]

Trends in Molecular Medicine, 2013
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, respectively. This drives a shift from an ATP-driven proinflammatory environment to an anti-inflammatory milieu induced ...
ANTONIOLI, LUCA, Pacher, P, Vizi, Es, Haskó, G.   +3 more
openaire   +3 more sources