Results 31 to 40 of about 51,093 (261)
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
An Exceptionally Potent Inhibitor of Human CD73 [PDF]
Biochemistry, 2019 We recently reported the initiation of a Phase I clinical trial with AB680, a potent human CD73 inhibitor, being developed for the treatment of solid tumors (NCT03677973). We undertook a detailed kinetic analysis of the interaction between human CD73 and AB680 to determine the mode of inhibition.
Christine E. Bowman +3 more
openaire +4 more sources
CD73 Promotes Age-Dependent Accretion of Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent atherosclerosis remains unclear.
Nadia R, Sutton +8 more
openaire +2 more sources
BioMed Research International, 2014 Purinergic signaling has emerged as an important player in cancer progression and is regulated by a series of nucleotidases. Among the enzyme cascade, CD73, which catelyzes AMP breakdown to adenosine, has been found to be overexpressed in many types of cancer. Various factors and mechanisms are employed to regulate expression of CD73.
Gao, Zhao-wei +2 more
openaire +3 more sources
Journal of Animal Reproduction and Biotechnology, 2016 Nucleotide metabolism in endothelium is variable between different species. Recent studies demonstrated that this variability could contribute coagulation dysfunction, even though organs of the alpha1,3-galactosyltransferase gene knockout pig were ...
Keon Bong Oh +7 more
doaj +1 more source
Frontiers in Genetics, 2021 To investigate the expression levels and prognostic value of CD73 in lung cancer. And moreover, to identify the effect and potential mechanism of CD73 on lung cancer cells proliferation and migration.
Zhao-wei Gao +6 more
doaj +1 more source
Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells [PDF]
, 2013 Recent studies have shown that Abs that target the cell-surface enzyme CD73 (ecto-5′-nucleotidase) reduce growth of primary tumors and metastasis in syngenic mice by inhibiting the catalytic activity of CD73, and thus increasing the activity of cytotoxic
Christensen, Eva Arnspang +6 more
core +1 more source
Targeting CD73 to augment cancer immunotherapy
Current Opinion in Pharmacology, 2020 CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal tissues to limit excessive immune response.
Meejeon Roh +4 more
openaire +2 more sources
PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment
Molecular & Cellular Oncology, 2017 The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells.
Ya-Ting Wang, Ruey-Hwa Chen
doaj +1 more source
CD73 expression and clinical significance in human metastatic melanoma. [PDF]
, 2018 CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target. CD73 expression was detected in TC in 54% of melanoma metastases, involving < 50% TC
Caux, C. +8 more
core +1 more source