Results 31 to 40 of about 36,605 (250)

Unlocking new frontiers: novel immune targets for next-generation cancer immunotherapy [PDF]

Korean Journal of Clinical Oncology
Cancer immunotherapy represents a transformative strategy in modern oncology, utilizing the body’s immune system to recognize and eliminate malignant cells with precision. Unlike traditional therapies, which often directly target the tumor, immunotherapy
Sufian Zaheer, Niti Sureka
doaj   +1 more source

CD73: Friend or Foe in Lung Injury

International Journal of Molecular Sciences, 2023
Ecto-5′-nucleotidase (CD73) plays a strategic role in calibrating the magnitude and chemical nature of purinergic signals that are delivered to immune cells. Its primary function is to convert extracellular ATP to adenosine in concert with ectonucleoside triphosphate diphosphohydrolase-1 (CD39) in normal tissues to limit an excessive immune response in
Hu, Xiu-Min, Shi, Nan-Rui, Zhang, Ji-Zhou, Zuo, Yan-Qin, Wang, Xin, Zhao, Ya-Fei, Wu, Jia-Si   +6 more
openaire   +2 more sources

Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]

, 2003
In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Kempkes, B., W. Gutensohn, Napieralski, R., Gutensohn, W., R. Napieralski, B. Kempkes   +5 more
core   +1 more source

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity [PDF]

, 2012
Background:Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers.
Monteverde, M, K Purdie, P Szlosarek, Fleming, C, Thompson, A, Szlosarek, P., Crook, T., Lo Nigro, C., M Merlano, Fleming, C., Purdie, K., Lattanzio, L., Proby, C., Inman, G. J., C Harwood, I Leigh, Lee, S, D Bergamaschi, Evans, A, C Lo Nigro, McHugh, A, E Hatzimichael, C Fleming, E Briasoulis, McHugh, A., Briasoulis, E, A McHugh, A Thompson, H Wang, N Syed, Szlosarek, P, Briasoulis, E., Inman, GJ, Monteverde, M., Matin, R, S Lee, M Monteverde, Thompson, A., N Mladkova, Proby, C, A Evans, G J Inman, Syed, N, Wang, H., Lee, S., Bergamaschi, D., L Lattanzio, Wang, H, Crook, Tim, Leigh, I, Nigro, C. Lo, R Matin, T Crook, Evans, A., Crook, T, Purdie, K, Merlano, M, Bergamaschi, D, Leigh, I., Lattanzio, L, Mladkova, N, Lo Nigro, C, Inman, G.J., Mladkova, N., Merlano, M., Hatzimichael, E., Hatzimichael, E, Harwood, C., Syed, N., Matin, R., Harwood, C, C Proby   +71 more
core   +1 more source

CD73: A Key Player in HIV Persistence [PDF]

, 2021
Replication of human immunodeficiency virus (HIV) is suppressed to undetectable levels by effective antiretroviral therapy (ART). However, current therapeutic regimens fail to completely eradicate HIV due to the persistence of latently-infected cells ...
Sperber, Hannah Sabeth
core   +1 more source

CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent MannerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Metabolic imbalance and inflammation are common features of chronic liver diseases. Molecular factors controlling these mechanisms represent potential therapeutic targets.
Karel P. Alcedo, Morgan A. Rouse, Gloria S. Jung, Dong Fu, Marquet Minor, Helen H. Willcockson, Kevin G. Greene, Natasha T. Snider   +7 more
doaj   +1 more source

In vitro study of the role of CD73 receptor and S100b protein in skin inflammation. [PDF]

, 2023
reservedÈ noto in letteratura che durante un’infiammazione cutanea si abbia un aumento dell’espressione di CD73 con un abbassamento delle difese immunitarie e un maggiore rilascio di proteina S100b, che per questa ragione è sfruttata come biomarker ...
NICOLETTI, MATTEO GENNARO
core  

Development of aortic endothelial cells to express CD37 and CD73 isolated from alpha 1,3-galactosyltransferase knock-out and MCP expressing pig

Journal of Animal Reproduction and Biotechnology, 2018
Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No, Sung-June Byun, Hyeon Yang, Sun A Ock, Jae-Seok Woo, Hwi-Cheul Lee, In-sul Hwang, Ji-Youn Kim, Sang Hyoun Park, Joo Young Lee, Keon Bong Oh   +10 more
doaj   +1 more source

A novel anti-CD73 antibody that selectively inhibits membrane 2 CD73 shows antitumor activity and induces tumor immune escape. [PDF]

, 2022
CD73 catalyzes the conversion of ATP to adenosine, which is involved in various physiological and pathological processes, including tumor immune escape.
Vick, B., Czogalla, Bastian, Reinhard Zeidler, Binje Vick, Neubeck, Bettina von, Zeidler, Reinhard, Kellner, Markus, Bettina von Neubeck, Regina Feederle, Czogalla, B., Kellner, M., Irmela Jeremias, von Neubeck, B., Jeremias, I., Bastian Czogalla, Feederle, Regina, Feederle, R., Vick, Binje, Zeidler, R., Markus Kellner, Jeremias, Irmela   +20 more
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source