Results 31 to 40 of about 38,724 (265)

The Roles of CD73 in Cancer

BioMed Research International, 2014
Purinergic signaling has emerged as an important player in cancer progression and is regulated by a series of nucleotidases. Among the enzyme cascade, CD73, which catelyzes AMP breakdown to adenosine, has been found to be overexpressed in many types of cancer. Various factors and mechanisms are employed to regulate expression of CD73.
Gao, Zhao-wei, Dong, Ke, Zhang, Hui-zhong   +2 more
openaire   +3 more sources

Development of aortic endothelial cells to express CD37 and CD73 isolated from alpha 1,3-galactosyltransferase knock-out and MCP expressing pig

Journal of Animal Reproduction and Biotechnology, 2018
Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No, Sung-June Byun, Hyeon Yang, Sun A Ock, Jae-Seok Woo, Hwi-Cheul Lee, In-sul Hwang, Ji-Youn Kim, Sang Hyoun Park, Joo Young Lee, Keon Bong Oh   +10 more
doaj   +1 more source

A novel anti-CD73 antibody that selectively inhibits membrane 2 CD73 shows antitumor activity and induces tumor immune escape. [PDF]

, 2022
CD73 catalyzes the conversion of ATP to adenosine, which is involved in various physiological and pathological processes, including tumor immune escape.
Vick, B., Czogalla, Bastian, Reinhard Zeidler, Binje Vick, Neubeck, Bettina von, Zeidler, Reinhard, Kellner, Markus, Bettina von Neubeck, Regina Feederle, Czogalla, B., Kellner, M., Irmela Jeremias, von Neubeck, B., Jeremias, I., Bastian Czogalla, Feederle, Regina, Feederle, R., Vick, Binje, Zeidler, R., Markus Kellner, Jeremias, Irmela   +20 more
core   +1 more source

Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2023
Background CD73 promotes progression in several malignancies and is considered as a novel immune checkpoint. However, the function of CD73 in intrahepatic cholangiocarcinoma (ICC) remains uncertain.
Bao-Ye Sun, Zhang-Fu Yang, Zhu-Tao Wang, Gao Liu, Cheng Zhou, Jian Zhou, Jia Fan, Wei Gan, Yong Yi, Shuang-Jian Qiu   +9 more
doaj   +1 more source

Graft-versus-host disease is enhanced by selective CD73 blockade in mice. [PDF]

PLoS ONE, 2013
CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models.
Long Wang, Jie Fan, Siqi Chen, Yi Zhang, Tyler J Curiel, Bin Zhang   +5 more
doaj   +1 more source

CD73 Promotes Chronic Lymphocytic Leukemia

, 2022
SIMPLE SUMMARY: Many patients with chronic lymphocytic leukemia (CLL) still fail current therapies. CD73 is a novel therapeutic target for solid tumors, but its role in CLL remains unclear.
Allard, David, Bertrand Allard, Allard, Bertrand, Tessier, Priscilla, Nathalie A. Johnson, Pavel Chrobak, Bergeron, Marjorie A., Stagg, John, David Allard, Marjorie A. Bergeron, Johnson, Nathalie A., Bareche, Yacine, Priscilla Tessier, Chrobak, Pavel, John Stagg, Yacine Bareche   +15 more
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

CD73, a significant protein in liver diseases [PDF]

, 2023
Purine adenosine pathway exists widely in the body metabolism, and is involved in regulating various physiological processes. It is one of the important pathways of environmental regulation in human body.
Qianqian Sun, Yuanyuan Chen, Heng Dai, Siliang Wang, Huilian Shi   +4 more
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment

Molecular & Cellular Oncology, 2017
The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells.
Ya-Ting Wang, Ruey-Hwa Chen
doaj   +1 more source