Results 31 to 40 of about 39,639 (239)

CHARACTERIZATION OF DIFFERENTIAL EXPRESSION PATTERNS OF THE EXTRACELLULAR PURINERGIC ENZYMES IN COLORECTAL CANCER

Trakya University Journal of Natural Sciences, 2022
The aim of this study is to characterize tumor cell specific expression of purinergic ecto-enzymes CD39 and CD73, and to associate prognostic significance of these expression patterns in colorectal cancer (CRC) patients.
Serkan Göktuna
doaj   +1 more source

Production of porcine fibroblasts carrying a vector enforced specific expression of CD73 to endothelial cells

Journal of Animal Reproduction and Biotechnology, 2016
Nucleotide metabolism in endothelium is variable between different species. Recent studies demonstrated that this variability could contribute coagulation dysfunction, even though organs of the alpha1,3-galactosyltransferase gene knockout pig were ...
Keon Bong Oh, Haesun Lee, Seongsoo Hwang, Sun-A Ock, Hak-Jae Chung, Sung June Byun, Poongyeon Lee, Gi-Sun Im   +7 more
doaj   +1 more source

Functional expression of CD73 on human natural killer cells

, 2022
The production of adenosine by CD73 on cancer cells in the tumor microenvironment is a recognized immunosuppressive mechanism contributing to immune evasion in many solid tumors.
Veenhuis, Paige, Cohen-Gadol, Aaron A., Dao, Tram N., Wang, Jiao, Chambers, Andrea M., Lupo, Kyle B., Slivova, Veronika, Matosevic, Sandro, Ayers, Mitchell G., Cohen‑Gadol, Aaron A., Mitchell G. Ayers, Jiao Wang, Kyle B. Lupo, Aaron A. Cohen-Gadol, Andrea M. Chambers, Veronika Slivova, Tram N. Dao, Sandro Matosevic, Paige Veenhuis   +18 more
core   +1 more source

Features of parameters of cellular immune depending on the activity of foci of demyelination in children with multiple sclerosis

Медицинская иммунология, 2023
MS is a common disease of the central nervous system that leads to disability and reduced quality of life. The debut of disease in 3-5% of patients occurs in childhood and has a less favorable course compared to adults.
T. V. Radygina, D. G. Kuptsova, O. V. Kurbatova, S. V. Petrichuk, E. L. Semikina, A. P. Fisenko, L. M. Abdullaeva, B. I. Bursagova   +7 more
doaj   +1 more source

CELL TYPE AND TISSUE SPECIFIC FUNCTIONS OF CD73 [PDF]

, 2018
CD73 is a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored glycoprotein that converts extracellular adenosine 5'-monophosphate (AMP) to adenosine.
Minor, Marquet
core   +1 more source

In vitro study of the role of CD73 receptor and S100b protein in skin inflammation.

, 2023
reservedÈ noto in letteratura che durante un’infiammazione cutanea si abbia un aumento dell’espressione di CD73 con un abbassamento delle difese immunitarie e un maggiore rilascio di proteina S100b, che per questa ragione è sfruttata come biomarker ...
NICOLETTI, MATTEO GENNARO
core  

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases

OncoImmunology, 2017
The emerging role for CD73 in driving cancer growth and metastasis has presented opportunities to develop anti-CD73 monoclonal antibodies (mAbs) in the treatment of human cancers.
Dipti Vijayan, Deborah S. Barkauskas, Kimberley Stannard, Erin Sult, Rebecca Buonpane, Kazuyoshi Takeda, Michele W. L. Teng, Kris Sachsenmeier, Carl Hay, Mark J. Smyth   +9 more
doaj   +1 more source

Determination of CD39 and CD73 expression together with their serum soluble levels in bronchial asthma [PDF]

Exploration of Immunology
Aim: This study aimed to evaluate the expression of ectonucleotidases cluster of differentiation 39 (ecto-adenosine triphosphate diphosphohydrolase) (CD39) and cluster of differentiation 73 (ecto-5’-nucleotidase) (CD73) and determine the serum levels of ...
Amany G. Thabit, Wegdan Elagan, Noha N. Tawifilis, Yousra Ezzat   +3 more
doaj   +1 more source

An Exceptionally Potent Inhibitor of Human CD73 [PDF]

Biochemistry, 2019
We recently reported the initiation of a Phase I clinical trial with AB680, a potent human CD73 inhibitor, being developed for the treatment of solid tumors (NCT03677973). We undertook a detailed kinetic analysis of the interaction between human CD73 and AB680 to determine the mode of inhibition.
Christine E. Bowman, Rafael G. da Silva, Amber Pham, Stephen W. Young   +3 more
openaire   +4 more sources

CD73 sustained cancer-stem-cell traits by promoting SOX9 expression and stability in hepatocellular carcinoma

Journal of Hematology & Oncology, 2020
Background Aberrant AKT activation contributes to cancer stem cell (CSC) traits in hepatocellular carcinoma (HCC). We previously reported that CD73 activated AKT signaling via the Rap1/P110β cascade.
Xiao-Lu Ma, Bo Hu, Wei-Guo Tang, Su-Hong Xie, Ning Ren, Lin Guo, Ren-Quan Lu   +6 more
doaj   +1 more source