Results 51 to 60 of about 36,481 (278)

CD73 Promotes Age-Dependent Accretion of Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent atherosclerosis remains unclear.
Nadia R, Sutton, Diane, Bouïs, Kris M, Mann, Imran M, Rashid, Alexandra L, McCubbrey, Matt C, Hyman, Daniel R, Goldstein, Annie, Mei, David J, Pinsky   +8 more
openaire   +2 more sources

CHARACTERIZATION OF DIFFERENTIAL EXPRESSION PATTERNS OF THE EXTRACELLULAR PURINERGIC ENZYMES IN COLORECTAL CANCER

Trakya University Journal of Natural Sciences, 2022
The aim of this study is to characterize tumor cell specific expression of purinergic ecto-enzymes CD39 and CD73, and to associate prognostic significance of these expression patterns in colorectal cancer (CRC) patients.
Serkan Göktuna
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy

Cancer Biology & Medicine
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages (TAMs), a key determinant of the tumor microenvironment (TME).
Lei Yang, Yi Zhang, Li Yang
doaj   +1 more source

CD73 is associated with poor prognosis in HNSCC

Oncotarget, 2016
CD73 is a cell surface immunosuppressive enzyme involved in tumor progression and metastasis. While patients whose cancer cells express elevated CD73 are typically associated with an unfavorable outcome, the clinical impact of CD73 expression in patients with Head and neck squamous cell carcinoma (HNSCC) remains unclear.
Ren, Zhen-Hu, Lin, Cheng-Zhong, Cao, Wei, Yang, Rong, Lu, Wei, Liu, Zhe-Qi, Chen, Yi-Ming, Yang, Xi, Tian, Zhen, Wang, Li-Zhen, Li, Jiang, Wang, Xu, Chen, Wan-Tao, Ji, Tong, Zhang, Chen-Ping   +14 more
openaire   +3 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Serum 5′-Nucleotidase as a Novel Predictor of Adverse Clinical Outcomes after Percutaneous Coronary Intervention in Patients with Coronary Artery Disease

Reviews in Cardiovascular Medicine
Background: The correlation between 5′-Nucleotidase (5′-NT) and the clinical outcomes in coronary artery disease (CAD) patients following percutaneous coronary intervention (PCI) is not clear. This study aims to clarify this relationship.
Mikereyi Aimaitijiang, Ting-Ting Wu, Ying-Ying Zheng, Xian-Geng Hou, Haitao Yang, Yi Yang, Xiang Xie   +6 more
doaj   +1 more source

Effect of AMP on CD73+/+ and CD73−/− BMDCs.

, 2012
A) AMP induced migration of immature BMDC generated from CD73+/+ and CD73−/− animals. DCs were stimulated with the indicated concentrations of AMP for 90 min.
Stephan Sorichter (163542), Elisabeth Panther (163502), Francesco Di Virgilio (163523), Sanja Cicko (163551), Marco Idzko (163581), Melanie Grimm (163532), Tobias Müller (163591), Yared Herouy (163560), Thorsten Dürk (163510), Johannes Norgauer (163569), Davide Ferrari (163517)   +10 more
core   +1 more source

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians [PDF]

, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Alfonso Cruz-Jentoft, Almudena Crooke, Martínez López, Joaquín, Martínez-Henández, Juan, Jesús Pintor, Crooke Álvarez, Almudena, Huete Toral, Fernando, Pintor, Jesús, Juan Martínez-Henández, Fernando Huete-Toral, Pintor Just, Jesús Jerónimo, Martínez-López, Joaquín, Crooke, Almudena, Cruz-Jentoft, Alfonso, Cruz Jentoft, Alfonso, Huete-Toral, Fernando, Joaquín Martínez-López, Martínez Henández, Juan   +17 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source