Results 51 to 60 of about 36,605 (250)

CHARACTERIZATION OF DIFFERENTIAL EXPRESSION PATTERNS OF THE EXTRACELLULAR PURINERGIC ENZYMES IN COLORECTAL CANCER

Trakya University Journal of Natural Sciences, 2022
The aim of this study is to characterize tumor cell specific expression of purinergic ecto-enzymes CD39 and CD73, and to associate prognostic significance of these expression patterns in colorectal cancer (CRC) patients.
Serkan Göktuna
doaj   +1 more source

Targeting CD73 to augment cancer immunotherapy

Current Opinion in Pharmacology, 2020
CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal tissues to limit excessive immune response.
Meejeon Roh, Derek A Wainwright, Jennifer D Wu, Yong Wan, Bin Zhang   +4 more
openaire   +2 more sources

CD73 affects GVHD development. [PDF]

, 2013
Lethally irradiated BALB/c CD73 KO (A) and WT (C) or B6D2F1 (BDF1) (D) mice were given i.v. injections of 5×106 T cell depleted bone marrow (BM) cells from C57BL/6 (B6) mice donors alone (n = 5) or with 2×107 splenocytes from WT (n = 10) or CD73 KO (n ...
Yi Zhang (9093), Jie Fan (258204), Siqi Chen (387248), Bin Zhang (64682), Long Wang (95893), Tyler J. Curiel (387249)   +5 more
core   +1 more source

CD73 promotes tumor growth and metastasis [PDF]

OncoImmunology, 2012
Our recent data and that of others demonstrate that both tumor and host CD73-generated adenosine promote tumor growth and metastasis in a multifactorial manner. Results with small molecule inhibitors or monoclonal antibodies against CD73 in multiple tumor models suggest that CD73 is a previously unappreciated important target for effective cancer ...
openaire   +2 more sources

CD73 sustained cancer-stem-cell traits by promoting SOX9 expression and stability in hepatocellular carcinoma

Journal of Hematology & Oncology, 2020
Background Aberrant AKT activation contributes to cancer stem cell (CSC) traits in hepatocellular carcinoma (HCC). We previously reported that CD73 activated AKT signaling via the Rap1/P110β cascade.
Xiao-Lu Ma, Bo Hu, Wei-Guo Tang, Su-Hong Xie, Ning Ren, Lin Guo, Ren-Quan Lu   +6 more
doaj   +1 more source

Features of parameters of cellular immune depending on the activity of foci of demyelination in children with multiple sclerosis

Медицинская иммунология, 2023
MS is a common disease of the central nervous system that leads to disability and reduced quality of life. The debut of disease in 3-5% of patients occurs in childhood and has a less favorable course compared to adults.
T. V. Radygina, D. G. Kuptsova, O. V. Kurbatova, S. V. Petrichuk, E. L. Semikina, A. P. Fisenko, L. M. Abdullaeva, B. I. Bursagova   +7 more
doaj   +1 more source

CD73 Promotes Age-Dependent Accretion of Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent atherosclerosis remains unclear.
Nadia R, Sutton, Diane, Bouïs, Kris M, Mann, Imran M, Rashid, Alexandra L, McCubbrey, Matt C, Hyman, Daniel R, Goldstein, Annie, Mei, David J, Pinsky   +8 more
openaire   +2 more sources

Immunohistochemical localization of CD73 in mouse brain. [PDF]

, 2013
Coronal sections of WT (panels A, C and E) and CD73 deficient (panels B, D and F) mouse cerebrums stained with CD73 antibody. The specific CD73 staining is detected in caudoputamen (CP), olfactory tubercle (OT), globus pallidus (GP) and meninx (arrow ...
Gennady G. Yegutkin (421106), Marjaana Peltola (421105), Natalia Kulesskaya (344724), Marko Salmi (101937), Sirpa Jalkanen (101938), Vootele Võikar (3212658), Heikki Rauvala (344725)   +6 more
core   +1 more source

CD73 expression and clinical significance in human metastatic melanoma [PDF]

, 2018
CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target.
Caux, C., Treilleux, I., Michielin, O., Inês Monteiro, Monteiro, I., Vigano, S., Romero, P., Ménétrier-Caux, C., Mohamed Faouzi, Pedro Romero, Faouzi, M., Laurence de Leval, Selena Vigano, Olivier Michielin, Christophe Caux, Christine Ménétrier-Caux, Isabelle Treilleux, de Leval, L.   +17 more
core   +1 more source

CD73 is associated with poor prognosis in HNSCC

Oncotarget, 2016
CD73 is a cell surface immunosuppressive enzyme involved in tumor progression and metastasis. While patients whose cancer cells express elevated CD73 are typically associated with an unfavorable outcome, the clinical impact of CD73 expression in patients with Head and neck squamous cell carcinoma (HNSCC) remains unclear.
Ren, Zhen-Hu, Lin, Cheng-Zhong, Cao, Wei, Yang, Rong, Lu, Wei, Liu, Zhe-Qi, Chen, Yi-Ming, Yang, Xi, Tian, Zhen, Wang, Li-Zhen, Li, Jiang, Wang, Xu, Chen, Wan-Tao, Ji, Tong, Zhang, Chen-Ping   +14 more
openaire   +3 more sources