Results 71 to 80 of about 38,724 (265)

Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer

OncoImmunology, 2017
CD39 and CD73 are surface-expressed ectonucleotidases that hydrolyze ATP in a highly regulated, serial manner into ADP, AMP and adenosine. The end product, adenosine, has both tumor-promoting and immunosuppressive effects.
Saly Al-Taei, Josephine Salimu, Lisa K. Spary, Aled Clayton, Jason F. Lester, Zsuzsanna Tabi   +5 more
doaj   +1 more source

CD73 affects GVHD development.

, 2013
Lethally irradiated BALB/c CD73 KO (A) and WT (C) or B6D2F1 (BDF1) (D) mice were given i.v. injections of 5×106 T cell depleted bone marrow (BM) cells from C57BL/6 (B6) mice donors alone (n = 5) or with 2×107 splenocytes from WT (n = 10) or CD73 KO (n ...
Yi Zhang (9093), Jie Fan (258204), Siqi Chen (387248), Bin Zhang (64682), Long Wang (95893), Tyler J. Curiel (387249)   +5 more
core   +1 more source

Biochemické nástroje k cílení imunomodulačního receptoru CD73 [PDF]

, 2022
New approaches to cancer treatment are investigated because cancer remains one of the most abundant causes of death. One of the promising fields of oncology is immunotherapy, which is based on the activation of immunity to eliminate malignant cells ...
Poukarová, Magdalena
core  

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

Pro-inflammatory Effect of Downregulated CD73 Expression in EAE Astrocytes [PDF]

, 2019
CD73, an ectonucleotidase, participates in the regulation of immune responses by controlling the conversion of extracellular AMP to adenosine. In this study, we investigated whether any type of brain cells, especially neuroglia cells, exhibit altered ...
Fanqiang Kong, Shumin Zhou, Guoping Liu, Zhiyun Wang, Jie Guo, Song Chen   +5 more
core   +1 more source

CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer

Scientific Reports, 2021
CD73 is a cell surface ecto-5′-nucleotidase, which converts extracellular adenosine monophosphate to adenosine. High tumor CD73 expression is associated with poor outcome among triple-negative breast cancer (TNBC) patients.
Nataliia Petruk, Sanni Tuominen, Malin Åkerfelt, Jesse Mattsson, Jouko Sandholm, Matthias Nees, Gennady G. Yegutkin, Arja Jukkola, Johanna Tuomela, Katri S. Selander   +9 more
doaj   +1 more source

Targeting CD73 in the tumor microenvironment with MEDI9447 [PDF]

OncoImmunology, 2016
MEDI9447 is a human monoclonal antibody that is specific for the ectoenzyme CD73 and currently undergoing Phase I clinical trials. Here we show that MEDI9447 is a potent inhibitor of CD73 ectonucleotidase activity, with wide ranging immune regulatory consequences.
Hay, Carl M., Sult, Erin, Huang, Qihui, Mulgrew, Kathy, Fuhrmann, Stacy R., McGlinchey, Kelly A., Hammond, Scott A., Rothstein, Raymond, Rios-Doria, Jonathan, Poon, Edmund, Holoweckyj, Nick, Durham, Nicholas M., Leow, Ching Ching, Diedrich, Gundo, Damschroder, Melissa, Herbst, Ronald, Hollingsworth, Robert E., Sachsenmeier, Kris F.   +17 more
openaire   +2 more sources

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway

Journal of Inflammation Research, 2022
Zhen-Ni Liu,1– 3 Xue Wu,1– 3 Qian Fang,1– 3 Zi-Xuan Li,1– 3 Guo-Qing Xia,1– 3 Jun-Nan Cai,1– 3 Xiong-Wen Lv1– 3 1Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui ...
Liu ZN, Wu X, Fang Q, Li ZX, Xia GQ, Cai JN, Lv XW   +6 more
doaj  

CD73 blockade alleviates collagen-induced arthritis by inhibiting synovial fibroblast activity [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Rheumatoid arthritis (RA) is a chronic autoimmune disease with progressive cartilage erosion and joint destruction. CD73 plays a critical role in regulating inflammatory responses. This study aims to investigate the effects of CD73 blockade
Xia-nan Wu, Rui-cheng Li, Ruo-xuan Hei, Chong Liu, Zhao-wei Gao, Xi Wang, Ke Dong   +6 more
doaj   +1 more source