Results 91 to 100 of about 36,481 (278)

CD73‐generated adenosine promotes osteoblast differentiation [PDF]

Journal of Cellular Physiology, 2012
AbstractCD731 is a GPI‐anchored cell surface protein with ecto‐5′‐nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73‐generated adenosine in bone tissue are largely unknown. To address this
Masahide, Takedachi, Hiroyuki, Oohara, Brenda J, Smith, Mitsuyoshi, Iyama, Mariko, Kobashi, Kenichiro, Maeda, Courtney L, Long, Mary B, Humphrey, Barbara J, Stoecker, Satoru, Toyosawa, Linda F, Thompson, Shinya, Murakami   +11 more
openaire   +2 more sources

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Immunohistochemical localization of CD73 in mouse brain.

, 2013
Coronal sections of WT (panels A, C and E) and CD73 deficient (panels B, D and F) mouse cerebrums stained with CD73 antibody. The specific CD73 staining is detected in caudoputamen (CP), olfactory tubercle (OT), globus pallidus (GP) and meninx (arrow ...
Gennady G. Yegutkin (421106), Marjaana Peltola (421105), Natalia Kulesskaya (344724), Marko Salmi (101937), Sirpa Jalkanen (101938), Vootele Võikar (3212658), Heikki Rauvala (344725)   +6 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

CD73 expression and clinical significance in human metastatic melanoma

, 2018
CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target.
Caux, C., Treilleux, I., Michielin, O., Inês Monteiro, Monteiro, I., Vigano, S., Romero, P., Ménétrier-Caux, C., Mohamed Faouzi, Pedro Romero, Faouzi, M., Laurence de Leval, Selena Vigano, Olivier Michielin, Christophe Caux, Christine Ménétrier-Caux, Isabelle Treilleux, de Leval, L.   +17 more
core   +1 more source

Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao, Riccardo Tognato, Micaela Natta, Elena Della Bella, Alessandro Cianciosi, Tiziano Serra   +5 more
wiley   +1 more source

Immunoregulatory roles of CD73 in lymphatic endothelial and myeloid cells [PDF]

, 2021
The immune system is a fascinating product of the interaction and cooperation of amultitude of cells and tissues. It is thereby able to distinguish between “friend” and “foe” and protect the host from a great variety of pathogens.
Eichin, Dominik
core  

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Bispecific antibodies targeting human CD73

, 2017
The present invention relates to a bispecific antibody targeting CD73. In particular, the present invention relates to a bispecific antibody targeting different epitopes on CD73 or a bispecific antibody targeting an epitope on CD73 and an epitope on a ...
Gammelgaard, Odd Lilleng, Ditzel, Henrik
core   +1 more source

Pro-inflammatory Effect of Downregulated CD73 Expression in EAE Astrocytes [PDF]

, 2019
CD73, an ectonucleotidase, participates in the regulation of immune responses by controlling the conversion of extracellular AMP to adenosine. In this study, we investigated whether any type of brain cells, especially neuroglia cells, exhibit altered ...
Fanqiang Kong, Shumin Zhou, Guoping Liu, Zhiyun Wang, Jie Guo, Song Chen   +5 more
core   +1 more source