Results 91 to 100 of about 38,724 (265)

CD73 polymorphisms are associated with schizophrenia

Purinergic Signalling
Abstract Ecto-5’-nucleotidase/CD73 enzyme plays a key role in the regulation of extracellular adenosine levels, thereby exerting influence on adenosine homeostasis. Emerging evidence suggests that perturbations in purines and ecto-5’-nucleotidase activity are associated with an augmented susceptibility to schizophrenia.
Peng, He-Xia, Zhang, Li-Li, Jiang, Dan, Jian, Na, Zhang, Ting-Mei, Luo, Jia-Guo, Yin, Hai-Yan   +6 more
openaire   +2 more sources

Role of CD73/adenosine/A2A pathway in the modulation of inflammatory processes

, 2017
Manipulation of the course or of the extension of an inflammatory reaction may include the effort not only to inhibit pro-inflammatory pathways but also through an approach able to enhance endogenous anti-inflammatory processes.
Elisabetta Caiazzo, Pellegrino Lippiello, Carla Cicala, Armando Ialenti   +3 more
core  

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Ruolo di due ectoenzimi, CD39 e CD73, nella modulazione dei processi infiammatori nel ratto

, 2008
La manipolazione del decorso e dell'intensità di un processo infiammatorio può avvenire non solo impiegando agenti che inibiscano le "pathways proinfiammatorie" attivate, ma anche mediante un approccio volto ad attivare i processi antinfiammatori ...
CICALA, CARLA
core  

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis

International Journal of Nanomedicine
Lingping Tan,1,2,* Chi Zhang,1,2,* Xiaoxing Kou,1– 3 Lu Zhao,4 Di Wu,1– 3 Jinyu Li,1,2 Chuanying Yu,1,2 Tansi Xu,1,2 Li Gao,1,2 Xueli Mao,1– 3 Chuanjiang Zhao1,2 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University ...
Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C   +10 more
doaj  

Unveiling the Role of Ecto-5′-Nucleotidase/CD73 in Astrocyte Migration by Using Pharmacological Tools

Frontiers in Pharmacology, 2018
CD73 is a bifunctional glycosylphosphatidylinositol (GPI)-anchored membrane protein which functions as ecto-5′-nucleotidase and a membrane receptor for extracellular matrix protein (ECM).
Marija Adzic, Marija Adzic, Nadezda Nedeljkovic   +2 more
doaj   +1 more source

Immunoregulatory roles of CD73 in lymphatic endothelial and myeloid cells [PDF]

, 2021
The immune system is a fascinating product of the interaction and cooperation of amultitude of cells and tissues. It is thereby able to distinguish between “friend” and “foe” and protect the host from a great variety of pathogens.
Eichin, Dominik
core  

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Expression of CD39 and CD73 Ectonucleotidases in Interferon--Treated Human Wharton\'s Jelly Mesenchymal Stem Cells [PDF]

Research in Molecular Medicine
Background: Mesenchymal stem cells (MSCs) exhibit substantial immunomodulatory properties. Interferon gamma (IFN-γ) exposure has been shown to enhance the immunoregulatory capacity of MSCs.
Leila Pirdel, Manijeh Pirdel
doaj