Results 91 to 100 of about 39,639 (239)

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis

International Journal of Nanomedicine
Lingping Tan,1,2,* Chi Zhang,1,2,* Xiaoxing Kou,1– 3 Lu Zhao,4 Di Wu,1– 3 Jinyu Li,1,2 Chuanying Yu,1,2 Tansi Xu,1,2 Li Gao,1,2 Xueli Mao,1– 3 Chuanjiang Zhao1,2 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University ...
Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C   +10 more
doaj  

Unveiling the Role of Ecto-5′-Nucleotidase/CD73 in Astrocyte Migration by Using Pharmacological Tools

Frontiers in Pharmacology, 2018
CD73 is a bifunctional glycosylphosphatidylinositol (GPI)-anchored membrane protein which functions as ecto-5′-nucleotidase and a membrane receptor for extracellular matrix protein (ECM).
Marija Adzic, Marija Adzic, Nadezda Nedeljkovic   +2 more
doaj   +1 more source

Allogeneic Human Bone Marrow‐Derived Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Inflammation Suppression and Angiogenesis Promotion: A Preclinical Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mesenchymal stem cells (MSCs) have been shown to enhance tissue regeneration and wound healing. This preclinical study investigated the therapeutic potential of human bone marrow‐derived mesenchymal stem cells (hBM‐MSCs) for accelerating diabetic wound healing.
Rong‐Fu Chen, Keng‐Fan Liu, Chia‐Chun Lee, Yu‐Han Chen, Hsin‐Hsin Shen, Yur‐Ren Kuo   +5 more
wiley   +1 more source

Autologous adipose‐derived mesenchymal stromal cell injection for knee osteoarthritis improves pain and function without a clear increase in adverse events: A systematic review and meta‐analysis of randomized controlled trials

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To systematically review randomized controlled trials and quantitatively evaluate the efficacy and safety of injections of autologous adipose‐derived mesenchymal stromal cells (AD‐MSCs) in patients with knee osteoarthritis (OA). Methods Multiple electronic databases were searched with no date restrictions for randomized controlled ...
Joo Hyung Han, Min Jung, Kwangho Chung, Hyun‐Soo Moon, Se‐Han Jung, Seung Hoon Baik, Jeongmo Koo, Woongseob Sim, Sung‐Hwan Kim   +8 more
wiley   +1 more source

Proposed mechanisms of isoflurane-mediated endothelial CD73 generation.

, 2014
We hypothesize that isoflurane via Rho kinase activation releases endothelial microparticles containing CD73. Increased endothelial microparticle CD73 converts AMP to adenosine which produces cytoprotective effects on neighboring endothelial cells or ...
Kevin M. Brown (182605), Mihwa Kim (580181), H. Thomas Lee (580184), Katelyn Yu-Mi Kim (580183), Ahrom Ham (580182)   +4 more
core   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

Effect of AMP on CD73+/+ and CD73−/− BMDCs.

, 2012
A) AMP induced migration of immature BMDC generated from CD73+/+ and CD73−/− animals. DCs were stimulated with the indicated concentrations of AMP for 90 min.
Stephan Sorichter (163542), Elisabeth Panther (163502), Francesco Di Virgilio (163523), Sanja Cicko (163551), Marco Idzko (163581), Melanie Grimm (163532), Tobias Müller (163591), Yared Herouy (163560), Thorsten Dürk (163510), Johannes Norgauer (163569), Davide Ferrari (163517)   +10 more
core   +1 more source

Expression of CD39 and CD73 Ectonucleotidases in Interferon--Treated Human Wharton\'s Jelly Mesenchymal Stem Cells [PDF]

Research in Molecular Medicine
Background: Mesenchymal stem cells (MSCs) exhibit substantial immunomodulatory properties. Interferon gamma (IFN-γ) exposure has been shown to enhance the immunoregulatory capacity of MSCs.
Leila Pirdel, Manijeh Pirdel
doaj  

Predictive value of CD73 expression for the efficacy of immune checkpoint inhibitors in NSCLC

Thoracic Cancer, 2020
Background CD73 induces the dephosphorylation of adenosine monophosphate converting it to adenosine, enabling malignancies to escape from immune surveillance.
Hidenobu Ishii, Koichi Azuma, Akihiko Kawahara, Takashi Kinoshita, Norikazu Matsuo, Yoshiko Naito, Takaaki Tokito, Kazuhiko Yamada, Jun Akiba, Tomoaki Hoshino   +9 more
doaj   +1 more source