Results 101 to 110 of about 36,605 (250)

Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao, Riccardo Tognato, Micaela Natta, Elena Della Bella, Alessandro Cianciosi, Tiziano Serra   +5 more
wiley   +1 more source

CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway

Journal of Inflammation Research, 2022
Zhen-Ni Liu,1– 3 Xue Wu,1– 3 Qian Fang,1– 3 Zi-Xuan Li,1– 3 Guo-Qing Xia,1– 3 Jun-Nan Cai,1– 3 Xiong-Wen Lv1– 3 1Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui ...
Liu ZN, Wu X, Fang Q, Li ZX, Xia GQ, Cai JN, Lv XW   +6 more
doaj  

CD73 blockade alleviates collagen-induced arthritis by inhibiting synovial fibroblast activity [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Rheumatoid arthritis (RA) is a chronic autoimmune disease with progressive cartilage erosion and joint destruction. CD73 plays a critical role in regulating inflammatory responses. This study aims to investigate the effects of CD73 blockade
Xia-nan Wu, Rui-cheng Li, Ruo-xuan Hei, Chong Liu, Zhao-wei Gao, Xi Wang, Ke Dong   +6 more
doaj   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population

OncoImmunology, 2018
Vγ9Vδ2 T cells contribute to the immune response against many tumor types through their direct cytotoxic activity and capacity to regulate the biological functions of other immune cells, such as dendritic cells and IFN-γ-producing CD8+ T cells.
Clément Barjon, Henri-Alexandre Michaud, Angeline Fages, Cécile Dejou, Alexandre Zampieri, Laetitia They, Aurélie Gennetier, Françoise Sanchez, Laurent Gros, Jean-François Eliaou, Nathalie Bonnefoy, Virginie Lafont   +11 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

CD73 promotes resistance to HER2/ErbB2 antibody therapy [PDF]

, 2017
Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb ...
Sotiriou, Christos, Sandra Pommey, Smyth, Mark John, Buisseret, Laurence, Vinu José, Vincent Delisle, Turcotte, Martin, Mittal, Deepak, Martin Turcotte, John Stagg, Joensuu, Heikki, Pirkko-Liisa Kellokumpu-Lehtinen, Laurence Buisseret, Allard, David, Jose, Vinu, Pommey, Sandra, Deepak Mittal, Delisle, Vincent, Sherene Loi, Heikki Joensuu, Mark J. Smyth, Stagg, John, Loi, Sherene, David Allard, Christos Sotiriou, Smyth, Mark J., Bareche, Yacine, Kellokumpu-Lehtinen, Pirkko-Liisa, Yacine Bareche   +28 more
core   +1 more source

PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES

Медицинская иммунология, 2018
Purinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease ...
A. S. Golovkin, I. A. Asadullina, I. V. Kudryavtsev   +2 more
doaj   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

CD73: double-breasted suit [PDF]

Science-Business eXchange, 2010
Australian researchers have shown that an anti-CD73 antibody can reduce both primary tumor growth and metastasis in animal models of breast cancer. The strategy may provide an option for advanced disease and treatment-resistant disease if unwanted immune side effects can be avoided.
openaire   +1 more source