Results 101 to 110 of about 36,481 (278)

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Role of CD73/adenosine/A2A pathway in the modulation of inflammatory processes

, 2017
Manipulation of the course or of the extension of an inflammatory reaction may include the effort not only to inhibit pro-inflammatory pathways but also through an approach able to enhance endogenous anti-inflammatory processes.
Elisabetta Caiazzo, Pellegrino Lippiello, Carla Cicala, Armando Ialenti   +3 more
core  

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Assessment of CD73 activity in breast cancer-derived small extracellular vesicles: application to monitoring of patients’ responses to immunotherapy

Immuno-Oncology and Technology
Background: We previously discovered that small extracellular vesicles (sEV) isolated from melanoma cells produce immunosuppressive adenosine (ADO) via the ATP→ADP→AMP→ADO pathway and that CD73 is the ‘gateway’ ecto-nucleotidase used by melanoma sEV to ...
T.L. Whiteside, S. Sehra, T. Chadderton, M. Guha, M.C. Stubbs, C. Timmers, E.K. Jackson   +6 more
doaj   +1 more source

CD73: double-breasted suit [PDF]

Science-Business eXchange, 2010
Australian researchers have shown that an anti-CD73 antibody can reduce both primary tumor growth and metastasis in animal models of breast cancer. The strategy may provide an option for advanced disease and treatment-resistant disease if unwanted immune side effects can be avoided.
openaire   +1 more source

Ruolo di due ectoenzimi, CD39 e CD73, nella modulazione dei processi infiammatori nel ratto

, 2008
La manipolazione del decorso e dell'intensità di un processo infiammatorio può avvenire non solo impiegando agenti che inibiscano le "pathways proinfiammatorie" attivate, ma anche mediante un approccio volto ad attivare i processi antinfiammatori ...
CICALA, CARLA
core  

Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis

International Journal of Nanomedicine
Lingping Tan,1,2,* Chi Zhang,1,2,* Xiaoxing Kou,1– 3 Lu Zhao,4 Di Wu,1– 3 Jinyu Li,1,2 Chuanying Yu,1,2 Tansi Xu,1,2 Li Gao,1,2 Xueli Mao,1– 3 Chuanjiang Zhao1,2 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University ...
Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C   +10 more
doaj  

Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer

OncoImmunology, 2017
CD39 and CD73 are surface-expressed ectonucleotidases that hydrolyze ATP in a highly regulated, serial manner into ADP, AMP and adenosine. The end product, adenosine, has both tumor-promoting and immunosuppressive effects.
Saly Al-Taei, Josephine Salimu, Lisa K. Spary, Aled Clayton, Jason F. Lester, Zsuzsanna Tabi   +5 more
doaj   +1 more source

Current Progress in Differentiating Crohn's Disease From Intestinal Tuberculosis

iLABMED, EarlyView.
Currently, there are various methods from different fields used to differentiate Crohn's disease from intestinal tuberculosis (ITB). Endoscopic findings are an important cornerstone. They can be used individually or in combination (models) to demonstrate excellent discriminative ability.
Chuyao Zhang, Xiaoyin Zhang
wiley   +1 more source

CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway

Journal of Inflammation Research, 2022
Zhen-Ni Liu,1– 3 Xue Wu,1– 3 Qian Fang,1– 3 Zi-Xuan Li,1– 3 Guo-Qing Xia,1– 3 Jun-Nan Cai,1– 3 Xiong-Wen Lv1– 3 1Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui ...
Liu ZN, Wu X, Fang Q, Li ZX, Xia GQ, Cai JN, Lv XW   +6 more
doaj