Results 111 to 120 of about 39,639 (239)

Research progress of CD39-CD73-adenosine pathway in immune regulation of hepatocellular carcinoma

Zhongguo Linchuang Yixue
Hepatocellular carcinoma (HCC) patients accounts for 85%-90% of all primary liver cancer patients. Surgical treatment methods, represented by resection and liver transplantation, have relatively good efficacy and are currently the preferred treatment ...
Lin SUN, Beili WANG, Wei GUO
doaj   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Optimising Haematopoietic Stem Cell Transplantation: Enhancing Myeloablation Sensitivity and Alleviating Anaemia Using Roxadustat (FG‐4592)

Cell Proliferation, EarlyView.
The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Guanheng Yang, Jiahui Wu, Xinbing Guo, Wenchen Shen, Xiao Sang, Xiuli Gong, Shu‐Zhen Huang, Jingzhi Zhang, Fanyi Zeng   +8 more
wiley   +1 more source

Supplementary Figures S1-7 from CD73 Expression Is an Independent Prognostic Factor in Prostate Cancer

, 2016
Supplementary Figures S1-7. Fig. S1: CD73 and CD8 protein expression Fig. S2: Distribution of CD73 and CD8 expression Fig. S3: Prognostic impact of CD73 using ROC-based cut-off Fig. S4: Prognostic impact of CD73 using ROC-based cut-off Fig.
Roxanne Charlebois (4804362), Bertrand Allard (13533994), Bruno G. Leclerc (15001334), John Stagg (769243), Sandra Pommey (13612321), Fred Saad (243995), Guillaume Chouinard (14920556)   +6 more
core   +1 more source

Human Embryonic Stem Cell‐Derived Immunity‐And‐Matrix‐Regulatory Cells Attenuate Pulmonary Fibrosis via MMP1‐Mediated Collagen Degradation

Cell Proliferation, EarlyView.
Human embryonic stem cell‐derived Immunity‐and‐Matrix‐Regulatory Cells (IMRCs) effectively attenuate pulmonary fibrosis by secreting Matrix Metalloproteinase‐1 (MMP1), which directly degrades excess collagen I in the extracellular matrix. By directly degrading collagen I, IMRCs reverse ECM stiffness, suppress myofibroblast activation, and promote a ...
Zhongwen Li, Dingyun Song, Faguo Sun, Licheng Song, Bin An, Tingting Gao, Jingjing Liu, Kan Zhang, Kaidi Liu, Kaiwei Wu, Yajing Li, Yi Yang, Yaru Liu, Ruofan Su, Zai Wang, Tiemei Zhao, Huaiyong Chen, Li Xiao, Liang Peng, Liu Wang, Wei Li, Lixin Xie, Jie Hao, Huaping Dai, Jun Wu   +24 more
wiley   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

MOESM6 of CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts

, 2019
Additional file 6: Table S1. Immunostaining for emmprin and CD73 in the tumor cells and stromal fibroblasts performed on ten tumors of surgically resected or biopsied epithelioid sarcoma.
M. Oyama (7374725), K. Koga (3355268), N. Koshikawa (7374722), B. Toole (7374734), M. Hamasaki (7374719), M. Seiki (7374731), M. Miyazaki (7374716), M. Aoki (2236873), H. Kozuka-Hata (7374728), K. Nabeshima (7374737)   +9 more
core   +1 more source

Assessment of CD73 activity in breast cancer-derived small extracellular vesicles: application to monitoring of patients’ responses to immunotherapy

Immuno-Oncology and Technology
Background: We previously discovered that small extracellular vesicles (sEV) isolated from melanoma cells produce immunosuppressive adenosine (ADO) via the ATP→ADP→AMP→ADO pathway and that CD73 is the ‘gateway’ ecto-nucleotidase used by melanoma sEV to ...
T.L. Whiteside, S. Sehra, T. Chadderton, M. Guha, M.C. Stubbs, C. Timmers, E.K. Jackson   +6 more
doaj   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis

Journal of Inflammation Research
Fangfang Xiang,1– 4,* Zhen Zhang,1,* Yuxin Nie,1 Xuesen Cao,1 Yang Li,1 Xiaohong Chen,1 Shaomin Gong,1 Jianzhou Zou,1 Jie Teng,1 Xiaoqiang Ding,1– 4 Bo Shen1– 4 1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People’s ...
Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B   +10 more
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