Results 111 to 120 of about 36,481 (278)
CD73 represses pro-inflammatory responses in human endothelial cells [PDF]
, 2010 Background CD73 is a 5'-ectonucleotidase that produces extracellular adenosine, which then acts on G protein-coupled purigenic receptors to induce cellular responses.
Ridley Anne J +5 more
core +1 more source
The regulation of stem cell fate and its application in neural regeneration
Interdisciplinary Medicine, EarlyView.Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He +3 more
wiley +1 more source
IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population
OncoImmunology, 2018 Vγ9Vδ2 T cells contribute to the immune response against many tumor types through their direct cytotoxic activity and capacity to regulate the biological functions of other immune cells, such as dendritic cells and IFN-γ-producing CD8+ T cells.
Clément Barjon +11 more
doaj +1 more source
PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES
Медицинская иммунология, 2018 Purinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease ...
A. S. Golovkin +2 more
doaj +1 more source
Predictive value of CD73 expression for the efficacy of immune checkpoint inhibitors in NSCLC
Thoracic Cancer, 2020 Background CD73 induces the dephosphorylation of adenosine monophosphate converting it to adenosine, enabling malignancies to escape from immune surveillance.
Hidenobu Ishii +9 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo +5 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley +1 more source
OncoImmunology, 2018 Background: The adenosine A2a receptor (A2aR) and the adenosine synthesizing enzyme CD73 have recently evolved as a novel immunotherapeutic target. However, little is known about epigenetic modification of the encoding genes ADORA2A and NT5E. Methods: In
Timo J. Vogt +7 more
doaj +1 more source
CD73 is a major regulator of adenosinergic signalling in mouse brain.
PLoS ONE, 2013 CD73 (ecto-5'-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5'-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiological
Natalia Kulesskaya +6 more
doaj +1 more source
Effect of various anti-CD73 antibodies on blocking the activity of CD73 bound MDA-MB-231 cells.
, 2019 Effect of various anti-CD73 antibodies on blocking the activity of CD73 bound MDA-MB-231 cells.
Said A. Goueli (7548320) +1 more
core +1 more source