Results 111 to 120 of about 36,605 (250)

A three-dimensional microenvironment alters CD73 expression in cervical cancer [PDF]

, 2021
Stem-like cells (CSCs) have a tumour-initiating capacity and play critical role in tumour metastasis, relapse and resistance to therapy. The ectoenzyme CD73, encoded by the NT5E gene, which catalyses the hydrolysis of AMP into adenosine, has been ...
Mello, Paola de Andrade, Pilger, Diogo Andre, Buffon, Andreia, Davies, Samuel, Wink, Marcia Rosangela, Iser, Isabele Cristiana, Bertoni, Ana Paula Santin, Santos, Jacqueline Fraga de Souza   +7 more
core  

Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis

International Journal of Nanomedicine
Lingping Tan,1,2,* Chi Zhang,1,2,* Xiaoxing Kou,1– 3 Lu Zhao,4 Di Wu,1– 3 Jinyu Li,1,2 Chuanying Yu,1,2 Tansi Xu,1,2 Li Gao,1,2 Xueli Mao,1– 3 Chuanjiang Zhao1,2 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University ...
Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C   +10 more
doaj  

Detailed analysis of adenosine A2a receptor (ADORA2A) and CD73 (5′-nucleotidase, ecto, NT5E) methylation and gene expression in head and neck squamous cell carcinoma patients

OncoImmunology, 2018
Background: The adenosine A2a receptor (A2aR) and the adenosine synthesizing enzyme CD73 have recently evolved as a novel immunotherapeutic target. However, little is known about epigenetic modification of the encoding genes ADORA2A and NT5E. Methods: In
Timo J. Vogt, Heidrun Gevensleben, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Diane Goltz, Dimo Dietrich   +7 more
doaj   +1 more source

Unveiling the Role of Ecto-5′-Nucleotidase/CD73 in Astrocyte Migration by Using Pharmacological Tools

Frontiers in Pharmacology, 2018
CD73 is a bifunctional glycosylphosphatidylinositol (GPI)-anchored membrane protein which functions as ecto-5′-nucleotidase and a membrane receptor for extracellular matrix protein (ECM).
Marija Adzic, Marija Adzic, Nadezda Nedeljkovic   +2 more
doaj   +1 more source

Inhibition by adenosine of fEPSP recordings in hippocampal slices from CD73^+/+ and CD73^−/− mice. [PDF]

, 2013
(a) Representative traces of fEPSPs; numbers 1–6 correspond to before and during superfusion of slices with adenosine (10, 25, 50 or 100 µM) or adenosine (100 µM) and DPCPX (1 µM) as indicated in (b).
Wei Xiong (58411), Chao Sun (139686), Benedict C. Albensi (318170), Fiona E. Parkinson (318171), Stephanie Chu (318169), Dali Zhang (318168)   +5 more
core   +1 more source

CD73 expression in normal and pathological human hepatobiliopancreatic tissues [PDF]

, 2019
BACKGROUND: The tumor-expressed CD73 ectonucleotidase generates immune tolerance and promotes invasiveness via adenosine production from degradation of AMP.
de Leval L, Halkic, N., Monteiro, I., de Leval, Laurence, Sciarra A, La Rosa, Stefano, Halkic N, Caux, Christophe, Romero P, Gilbert, Benoit, Ménétrier-Caux C, La Rosa S, Caux, C., Halkic, Nermin, Romero, P., Caux C, Ménétrier-Caux, C., La Rosa, S., Gilbert B, Sciarra, Amedeo, Sempoux, Christine, Ménétrier-Caux, Christine, Sempoux, C., Monteiro, Inês, Sciarra, A., Gilbert, B., Romero, Pedro, Monteiro I, Sempoux C, de Leval, L.   +29 more
core   +1 more source

Assessment of CD73 activity in breast cancer-derived small extracellular vesicles: application to monitoring of patients’ responses to immunotherapy

Immuno-Oncology and Technology
Background: We previously discovered that small extracellular vesicles (sEV) isolated from melanoma cells produce immunosuppressive adenosine (ADO) via the ATP→ADP→AMP→ADO pathway and that CD73 is the ‘gateway’ ecto-nucleotidase used by melanoma sEV to ...
T.L. Whiteside, S. Sehra, T. Chadderton, M. Guha, M.C. Stubbs, C. Timmers, E.K. Jackson   +6 more
doaj   +1 more source

CD73 represses pro-inflammatory responses in human endothelial cells [PDF]

, 2010
Background CD73 is a 5'-ectonucleotidase that produces extracellular adenosine, which then acts on G protein-coupled purigenic receptors to induce cellular responses.
Ridley Anne J, Gruenewald, Jana K. G., Ridley, Anne J., Anne J Ridley, Grünewald Jana KG, Jana KG Gr�newald   +5 more
core   +1 more source

CD73 is associated with glycolysis related metabolic programs and CD8+ T cell suppression in pancreatic ductal adenocarcinoma

Frontiers in Immunology
CD73 is an enzyme that generates extracellular adenosine and has been implicated in tumor-associated immune suppression, but its biological and clinical significance in pancreatic ductal adenocarcinoma (PDAC) remains incompletely understood.
Eriko Katsuta, Aarohan Mukherjee Burma, Eito Nakagawa, Ken Oh, Tao Dai, Subhamoy Dasgupta, Kazuaki Takabe, Kazuaki Takabe, Daisuke Ban   +8 more
doaj   +1 more source

Predictive value of CD73 expression for the efficacy of immune checkpoint inhibitors in NSCLC

Thoracic Cancer, 2020
Background CD73 induces the dephosphorylation of adenosine monophosphate converting it to adenosine, enabling malignancies to escape from immune surveillance.
Hidenobu Ishii, Koichi Azuma, Akihiko Kawahara, Takashi Kinoshita, Norikazu Matsuo, Yoshiko Naito, Takaaki Tokito, Kazuhiko Yamada, Jun Akiba, Tomoaki Hoshino   +9 more
doaj   +1 more source