Results 131 to 140 of about 36,481 (278)

CELL TYPE AND TISSUE SPECIFIC FUNCTIONS OF CD73

, 2018
CD73 is a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored glycoprotein that converts extracellular adenosine 5'-monophosphate (AMP) to adenosine.
Minor, Marquet
core   +1 more source

CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma

, 2020
CD73 is involved in tumor immune escape and promotes the growth and progression of cancer cells. The functional role of CD73 expression in papillary thyroid carcinoma (PTC) has not yet been established.
Tae-Min Kim, Haejin Cho, Yourha Kim, Sora Jeon, Chan Kwon Jung, Young Mun Jeong, Andrey Bychkov   +6 more
core   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis

Journal of Inflammation Research
Fangfang Xiang,1– 4,* Zhen Zhang,1,* Yuxin Nie,1 Xuesen Cao,1 Yang Li,1 Xiaohong Chen,1 Shaomin Gong,1 Jianzhou Zou,1 Jie Teng,1 Xiaoqiang Ding,1– 4 Bo Shen1– 4 1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People’s ...
Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B   +10 more
doaj  

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Utility of combined CD39/CD73/CD38 expression for the detection of malignant T cells in Sézary syndrome

British Journal of Haematology, EarlyView.
Summary Sézary syndrome (SS) is an aggressive cutaneous T‐cell lymphoma, characterized by erythroderma, lymphadenopathy and circulating malignant CD4+ T cells. Despite therapeutic advances, SS remains an incurable disease. Early diagnosis is therefore essential for timely therapeutic intervention; however, reliable biomarkers to identify circulating SS
Sara Marchisio, Yuliya Yakymiv, Liyun Lin, Erika Ortolan, Verdiana Pullano, Renata Ponti, Fenna J. de Bie, Alita J. van der Sluijs‐Gelling, Willem H. Zoutman, Valentina Pala, Ferenc A. Scheeren, Maarten H. Vermeer, Ada Funaro, Pietro Quaglino, Gabriele Roccuzzo   +14 more
wiley   +1 more source

CD73 promotes resistance to HER2/ErbB2 antibody therapy

, 2017
Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb ...
Sotiriou, Christos, Sandra Pommey, Smyth, Mark John, Buisseret, Laurence, Vinu José, Vincent Delisle, Turcotte, Martin, Mittal, Deepak, Martin Turcotte, John Stagg, Joensuu, Heikki, Pirkko-Liisa Kellokumpu-Lehtinen, Laurence Buisseret, Allard, David, Jose, Vinu, Pommey, Sandra, Deepak Mittal, Delisle, Vincent, Sherene Loi, Heikki Joensuu, Mark J. Smyth, Stagg, John, Loi, Sherene, David Allard, Christos Sotiriou, Smyth, Mark J., Bareche, Yacine, Kellokumpu-Lehtinen, Pirkko-Liisa, Yacine Bareche   +28 more
core   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

A three-dimensional microenvironment alters CD73 expression in cervical cancer

, 2021
Stem-like cells (CSCs) have a tumour-initiating capacity and play critical role in tumour metastasis, relapse and resistance to therapy. The ectoenzyme CD73, encoded by the NT5E gene, which catalyses the hydrolysis of AMP into adenosine, has been ...
Mello, Paola de Andrade, Pilger, Diogo Andre, Buffon, Andreia, Davies, Samuel, Wink, Marcia Rosangela, Iser, Isabele Cristiana, Bertoni, Ana Paula Santin, Santos, Jacqueline Fraga de Souza   +7 more
core