Results 131 to 140 of about 36,605 (250)
CD73 and adenosine generation in the creation of regulatory microenvironments
Clinical and Experimental Immunology, 2012 SummaryExtracellular adenosine 5′-triphosphate (ATP) acts on many immune cells to promote inflammation. Conversely, the ATP metabolite adenosine is mainly an anti-inflammatory molecule. The ecto-enzymes CD39 and CD73 can dephosphorylate extracellular ATP to adenosine, thereby controlling this important pathway of immune modulation.
Regateiro, F, Cobbold, S, Waldmann, H
openaire +4 more sources
Therapeutic Value of CD73 as a Biomarker in Human Cancer [PDF]
, 2019 Context: Over the past several years, biomarkers have emerged as a diagnostic and therapeutic tool for cancer therapy. CD73 (ecto-5'-nucleotidase) which is a cell surface ectonucleotidase, mediates the conversion of extracellular Adenosine monophosphate (
Hashemi, Mehrdad +3 more
core +2 more sources
The Journal of Pathology, EarlyView.Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi +8 more
wiley +1 more source
Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells [PDF]
, 2013 Recent studies have shown that Abs that target the cell-surface enzyme CD73 (ecto-5'-nucleotidase) reduce growth of primary tumors and metastasis in syngenic mice by inhibiting the catalytic activity of CD73, and thus increasing the activity of cytotoxic
Ditzel, Henrik J +6 more
core +1 more source
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
Precision Medical Sciences, EarlyView.This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
CD73: A Promising Biomarker in Cancer Patients [PDF]
Frontiers in Pharmacology, 2020 Turiello R., Pinto A., Morello S.
openaire +3 more sources
Methods and tools for studying ecto-5'-nucleotidase (CD73) [PDF]
Ecto-5’-nucleotidase (CD73), a glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed mainly in the membranes of immune and endothelial cells and released in exosomes or as a soluble protein, has emerged as a potential target in cancer ...
Idris, Riham Mohammed Omer Ali
core +1 more source
Proposed mechanisms of isoflurane-mediated endothelial CD73 generation. [PDF]
, 2014 We hypothesize that isoflurane via Rho kinase activation releases endothelial microparticles containing CD73. Increased endothelial microparticle CD73 converts AMP to adenosine which produces cytoprotective effects on neighboring endothelial cells or ...
Kevin M. Brown (182605) +4 more
core +1 more source
VIEW, EarlyView.Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang +5 more
wiley +1 more source
27‐color flow cytometry for measurable residual disease detection in B‐cell lymphoblastic leukemia
Cytometry Part B: Clinical Cytometry, EarlyView.
Ryan C. Shean +3 more
wiley +1 more source