Results 141 to 150 of about 36,481 (278)

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

Inhibition by adenosine of fEPSP recordings in hippocampal slices from CD73^+/+ and CD73^−/− mice.

, 2013
(a) Representative traces of fEPSPs; numbers 1–6 correspond to before and during superfusion of slices with adenosine (10, 25, 50 or 100 µM) or adenosine (100 µM) and DPCPX (1 µM) as indicated in (b).
Wei Xiong (58411), Chao Sun (139686), Benedict C. Albensi (318170), Fiona E. Parkinson (318171), Stephanie Chu (318169), Dali Zhang (318168)   +5 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Research progress of CD39-CD73-adenosine pathway in immune regulation of hepatocellular carcinoma

Zhongguo Linchuang Yixue
Hepatocellular carcinoma (HCC) patients accounts for 85%-90% of all primary liver cancer patients. Surgical treatment methods, represented by resection and liver transplantation, have relatively good efficacy and are currently the preferred treatment ...
Lin SUN, Beili WANG, Wei GUO
doaj   +1 more source

CD73 expression in normal and pathological human hepatobiliopancreatic tissues

, 2019
BACKGROUND: The tumor-expressed CD73 ectonucleotidase generates immune tolerance and promotes invasiveness via adenosine production from degradation of AMP.
de Leval L, Halkic, N., Monteiro, I., de Leval, Laurence, Sciarra A, La Rosa, Stefano, Halkic N, Caux, Christophe, Romero P, Gilbert, Benoit, Ménétrier-Caux C, La Rosa S, Caux, C., Halkic, Nermin, Romero, P., Caux C, Ménétrier-Caux, C., La Rosa, S., Gilbert B, Sciarra, Amedeo, Sempoux, Christine, Ménétrier-Caux, Christine, Sempoux, C., Monteiro, Inês, Sciarra, A., Gilbert, B., Romero, Pedro, Monteiro I, Sempoux C, de Leval, L.   +29 more
core   +1 more source

Dentine Regeneration With Calcium Strontium Silicate: In Vitro Odontogenic Differentiation, Antimicrobial Activity, Immunomodulation and In Vivo Pulpotomy in Rat Molars

International Endodontic Journal, EarlyView.
ABSTRACT Aim This study examined the in vitro and in vivo performance of calcium strontium silicate (CSR) as a novel biomaterial for vital pulp therapy (VPT), assessing its odontogenic differentiation, antibacterial activity, immunomodulation, inflammatory response and dentine regeneration potential compared to calcium silicate (CS) and Mineral ...
Mohamed Mahmoud Abdalla, Vidhyashree Rajasekar, Heba Ahmed, Mengyu Huang, Cynthia Kar Yung Yiu   +4 more
wiley   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

Inhibition by ATP of fEPSP recordings in hippocampal slices from CD73^+/+ and CD73^−/− mice.

, 2013
(a) Representative traces of fEPSPs; numbers 1–6 correspond to before and during superfusion of slices with ATP (10, 25, 50 or 100 µM) or ATP (100 µM) and DPCPX (1 µM) as indicated in (b).
Wei Xiong (58411), Chao Sun (139686), Benedict C. Albensi (318170), Fiona E. Parkinson (318171), Stephanie Chu (318169), Dali Zhang (318168)   +5 more
core   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

A novel role of CD73-IFNγ signalling axis in human mesenchymal stromal cell mediated inflammatory macrophage suppression

Regenerative Therapy
Introduction: Immunomodulation is the predominant mechanism via which Mesenchymal stromal cells (MSCs) mediate their therapeutic benefits. However, inconsistent success in numerous clinical trials warrants a better understating of the molecular ...
Shashank Chandanala, Govind Mohan, David-Luther Manukonda, Anujith Kumar, Jyothi Prasanna   +4 more
doaj   +1 more source