Results 161 to 170 of about 36,605 (250)

High‐altitude headache: Insights into pathophysiology and potential treatment implications

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla, Florian Frank, Giacomo Strapazzon, Justin Lawley   +3 more
wiley   +1 more source

Doxorubicin‐Induced Cytotoxicity in Adipose‐Derived Stem Cells Is Associated With Altered SAPK/JNK Signaling

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
This study investigated the effects of clinically relevant concentrations of doxorubicin (Dox; 5 μM), commonly used in anticancer therapy, on adipose‐derived stem cells (ADSCs). Dox induced ADSC dysfunction, characterized by reduced mitochondrial activity, apoptosis, oxidative stress, premature senescence, cytoskeletal alterations, and cell cycle ...
Aleksandra Skubis‐Sikora, Kinga Pogoda‐Mieszczak, Bartosz Sikora, Edyta Bogunia, Aleksandra Bryzek, Piotr Czekaj   +5 more
wiley   +1 more source

IL‐6 Upregulates CD73 in Human Placental Mesenchymal Stem Cells to Promote ATRA‐Induced NB4 Cell Differentiation in Acute Promyelocytic Leukemia

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Purpose To investigate the expression profile of IL‐6 in patients with acute promyelocytic leukemia (APL) and its role in modulating the ability of hPMSCs to regulate the differentiation of NB4 cells. Methods Peripheral blood samples were obtained from newly diagnosed APL patients and healthy controls.
Rong Qi, Hengchao Zhang, Yunhua Wu, Yanchao Ma, Xiying Luan   +4 more
wiley   +1 more source

Exosomal TGM2 From Hypoxia‐Primed Olfactory Mucosa MSCs Attenuates Senescent Astrocytes via NRF1/TFAM Signaling in Parkinson's Disease

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Hypoxia‐preconditioned olfactory mucosa mesenchymal stem cells (OM‐MSCs) release exosomes enriched with transglutaminase 2 (TGM2), which are taken up by astrocytes. Inside the nucleus, TGM2 activates NRF1, leading to the upregulation of TFAM. This enhances mitochondrial function by reducing mitochondrial DNA (mtDNA) leakage and improving mitochondrial ...
Xiqi Hu, Yuchang Liang, Hong Fan, Wenqi Fan, Zijie Wang, Ya‐nan Ma, Peipei Song, Ying Xia   +7 more
wiley   +1 more source

T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis

International Journal of Nanomedicine
Xiaoshan Yang,1– 3,* Yang Zhou,2,3,* Fuxing Zhou,4,* Lili Bao,2,3 Zhengyan Wang,5 Zihan Li,2,3 Feng Ding,2,3 Huijuan Kuang,6,7 Huan Liu,8 Shenglong Tan,1 Xinyuan Qiu,1 Huan Jing,9 Shiyu Liu,2,3 Dandan Ma1 1Department of Endodontics ...
Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D   +13 more
doaj  

Extracellular Vesicles in Acute Myeloid Leukemia: Opportunities and Obstacles for Therapeutic Advancement

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show limited response to standard therapies, emphasizing the need for novel, safe, and more effective targeted ...
Rongrong Hu, Zaker Ataullev, Luping Lou
wiley   +1 more source

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, Volume 183, Issue 16, Page 4761-4777, August 2026.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle-invasive bladder cancer. [PDF]

J Pathol Clin Res
Ledderose S, Schwenke J, Eismann L, Rodler S, Rudelius M, Ledderose C.   +5 more
europepmc   +1 more source

Dual-mechanism anti-CD73 antibodies CR201 and CR202 targeting distinct domains for cancer immunotherapy. [PDF]

Front Immunol
Zhang M, Yuan H, Pan X, Li X, Wang Z, Zhang S, Gu Z, Hu B, Qu X, Wang Q, Gu X, Wang B, Cao Y, Mu G, Kang G, de Marco A, Zhou X, Huang H.   +17 more
europepmc   +1 more source