Results 171 to 180 of about 36,481 (278)

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, Volume 13, Issue 35, 24 June 2026.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis

International Journal of Nanomedicine
Xiaoshan Yang,1– 3,* Yang Zhou,2,3,* Fuxing Zhou,4,* Lili Bao,2,3 Zhengyan Wang,5 Zihan Li,2,3 Feng Ding,2,3 Huijuan Kuang,6,7 Huan Liu,8 Shenglong Tan,1 Xinyuan Qiu,1 Huan Jing,9 Shiyu Liu,2,3 Dandan Ma1 1Department of Endodontics ...
Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D   +13 more
doaj  

Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom. [PDF]

Signal Transduct Target Ther
Luo G, Ma F, Yang Y, Yang C, Li X, Xie J, Xiong K, Chen P, Ma K, Zhao Z, Tang BZ, Duo Y.   +11 more
europepmc   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Evaluating the Serum Levels of CD73 in Patients with Head and Neck Squamous Cell Carcinoma. [PDF]

J Dent (Shiraz)
Zare R, Ranjbar MA, Ebrahimi A, Malekzadeh M, Khademi B, Savadi N.   +5 more
europepmc   +1 more source

Machine Learning for Raman Spectroscopy Glioblastoma Classification

Journal of Chemometrics, Volume 40, Issue 6, June 2026.
ABSTRACT This study presents a comprehensive evaluation of various computational models for glioblastoma cell classification using Raman spectroscopy data. We compare traditional machine learning methods such as support vector machines, boosting and random forests with more modern methods including convolutional neural networks, vision transformers and
Brendan McCane, Irsyaad Rijwan, Sara J. Fraser‐Miller, Silke Neumann, Donata Maciaczyk, Jaroslaw Maciaczyk, Keith Gordon   +6 more
wiley   +1 more source

CD4+ T Cells Sensitize Quasimesenchymal Breast Tumors Lacking CD73 to Anti-CTLA4 Immune Checkpoint Blockade Therapy. [PDF]

Cancer Res Commun
Chandraganti S, Sams C, Sahoo S, Feng B, O'Connell I, Li L, Nepal S, Pulukuri S, Bakhle K, Thiru P, Simian C, Maymi V, Rudd BD, Bell GW, Hatfield S, Jolly MK, Dongre A.   +16 more
europepmc   +1 more source

Effect of C5a Receptor Antagonist on the Osteogenic Differentiation of Dental Pulp Stem Cells

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objective Complement component 5a (C5a) binding to its receptor (C5aR) can mediate pro‐inflammatory immune responses, which impairs osteogenic differentiation of dental pulp stem cells (DPSCs). The present study aimed to evaluate the regulatory effect of C5aR antagonist (W54011) on the osteogenic differentiation of DPSCs in an in vitro ...
Xiaohan Tan, Junlong Hu, Junhui Li, Zhuangying Chen, Xin Shi, Jie Liu, Mingyue Liu, Weiping Hu   +7 more
wiley   +1 more source