Results 171 to 180 of about 38,724 (265)

Immune Checkpoint Inhibitors in Cancer Therapy: Clinical Landscape, Resistance Mechanisms, and Therapeutic Innovations

MedComm – Oncology, Volume 5, Issue 3, September 2026.
The up‐to‐date clinical progress of immune checkpoint inhibitor (ICI) therapy in solid tumors, specifically the combinational regimens between ICIs and other treatment strategies, the mechanisms underlying primary and acquired resistance, and mechanism‐matched strategies to improve clinical outcomes are synthesized in this review.
Qiongyu Zhang, Zhi Qin, Caijuan Guo
wiley   +1 more source

Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle-invasive bladder cancer. [PDF]

J Pathol Clin Res
Ledderose S, Schwenke J, Eismann L, Rodler S, Rudelius M, Ledderose C.   +5 more
europepmc   +1 more source

Cell‐Type‐Resolved Proteomics Reveals Distinct Immune and Metabolic Programs Between Primary and Recurrent Ascites in HGSOC

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT High‐grade serous ovarian carcinoma (HGSOC) frequently recurs after platinum–taxane therapy, yet recurrence‐associated changes within ascites remain unclear. We performed cell‐type‐resolved quantitative proteomics on paired ascites samples collected at primary diagnosis and at disease recurrence from three HGSOC patients, profiling unsorted ...
Bo Ren, Kenneth Weke, Darryl Hardie, Sarah MacPherson, Javier A Alfaro, Julian J Lum, David R Goodlett   +6 more
wiley   +1 more source

Friend or foe: divergent immunomodulatory effects of metabolites derived from the virucidal zinc finger inhibitor SAMT-247. [PDF]

Front Immunol
Woode EK, Goldfarbmuren KC, Arisa OT, Bissa M, Schifanella L, Robello M, Gunawardana M, Moss JA, Castonguay AE, Butkyavichene I, Jenkins LM, Ettienne EB, Appella DH, Baum MM, Figg WD, Franchini G, Rahman MA.   +16 more
europepmc   +1 more source

Einfluss von Glukoseentzug auf die Expression von CD73 und Evaluierung eines CD73-Knockouts in Leberkrebs-Zelllinien

Das hepatozelluläre Karzinom (HCC) weist aufgrund der häufigen Diagnose im fortgeschrittenen Stadium, der phänotypischen Heterogenität und der Entwicklung von Therapieresistenz eine hohe Mortalitätsrate auf.
Knöfler, Simon
core  

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, Volume 15, Issue 3, Page 176-193, September 2026.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Cancer associated fibroblast-T cell crosstalk promotes purinergic synthesis in non-small cell lung cancer (NSCLC). [PDF]

Oncoimmunology
Koppensteiner L, Lochenie C, O'Connor RA, Mathieson L, Neilson L, Akram AR.   +5 more
europepmc   +1 more source

hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle‐Activating Capacity

Aging Cell, Volume 25, Issue 9, September 2026.
hTERT immortalization stabilizes hUCMSC‐derived sEV function by alleviating cellular senescence and preserving young‐like cargo profiles. H11‐sEVs retain immunomodulatory activity, primordial follicle‐activating capacity, and ovarian protective effects.
Yating Chen, Wei Liu, Ying Tian, Xinyu Wang, Haonan Fan, Mingyu Yang, Feiyang Diao, Jing Li   +7 more
wiley   +1 more source

Stratification of Prognosis in Pulmonary Pleomorphic Carcinoma Based on Integrated PD-L1 and Multiparametric Biomarker Analysis. [PDF]

Cancers (Basel)
Honda Y, Shimajiri S, Manabe T, Nemoto Y, Oyama R, Nishizawa N, Matsumiya H, Nabe Y, Takenaka M, Kuroda K, Tanaka F, Uramoto H.   +11 more
europepmc   +1 more source

3D Culture Reverses Limbal Niche Cell Replicative Aging via FOSL1 Upregulation

Aging Cell, Volume 25, Issue 9, September 2026.
3D culture reverses LNC replicative aging via FOSL1 upregulation, enhancing mitochondrial function and alleviating oxidative stress. ABSTRACT Limbal niche cells (LNCs) serve as essential regulators of limbal microenvironmental homeostasis and corneal epithelial wound repair, representing a promising therapeutic resource for limbal stem cell deficiency (
Xuying Wang, Shen Li, Zibin Liu, Xinghan Guo, Jiachao Shen, Tianyu Zhou, Shuying Liao, Xiaoyu Huang, Wei Wang, Lingjuan Xu, Xinjie Zang, Guigang Li   +11 more
wiley   +1 more source