Results 191 to 200 of about 36,481 (278)

Acute effects of a single electroacupuncture session on purinergic signaling and inflammatory markers in patients with chronic nonspecific low back pain: a pilot study. [PDF]

Purinergic Signal
Ecco JC, Ansolin V, Soares AA, Dalagnol AMK, Marafon F, Franscescon F, Bianchini MC, de Resende E Silva DT.   +7 more
europepmc   +1 more source

Label‐Free Clustering Analysis Platform Drives Cascaded Workflow for Scalable Production of Therapeutic Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) have emerged as highly promising natural nanomedicines and nanocarriers, holding transformative potential for the treatment of various diseases. However, the lack of rapid and comprehensive characterization techniques for EV preparation analysis, coupled with the absence of efficient quality control methods ...
Jing Zhou, Ping Chen, Xin Chen, Xu Xiao, Haonan Di, Yunyun Hu, Yarong Zhen, Xiaomei Yan   +7 more
wiley   +1 more source

Dual CD73/A_2AR blockade modulates the neurotoxic astrocyte phenotype without disrupting core inflammatory signaling. [PDF]

Front Pharmacol
Mihajlovic K, Dragic M, Adzic Bukvic M, Martic T, Stevanovic I, Vinit S, Bleuzé M, Mansart A, Adam L, Nedeljkovic N.   +9 more
europepmc   +1 more source

Pre‐Conditioned Bone Marrow Mesenchymal Stromal Cell‐Derived Secretome Exerts an Anti‐Inflammatory Effect on Degenerative Nucleus Pulposus Cells In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
IL‐1β‐preconditioned BM‐MSC‐derived secretome counteracts inflammation‐driven degeneration in hNPCs. BM‐MSCs were preconditioned with IL‐1β (10 ng/mL) for 24 h, and the resulting secretome (BM‐MSCsec) was collected. Degenerative hNPCs cultured in a 3D alginate bead model were exposed to IL‐1β to reproduce an inflammatory degenerative microenvironment ...
Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Giuseppina Di Giacomo, Claudia Cicione, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro   +7 more
wiley   +1 more source

Revisiting MSC heterogeneity: significance of the CD73⁺CD39⁺CD146⁺ perivascular subset in bone marrow. [PDF]

Front Bioeng Biotechnol
Rajendran RL, Mahajan AA, Ahn BC, Gangadaran P.   +3 more
europepmc   +1 more source

Semi‐Automated Platform for Early Prenatal Coelocentesis Testing Using Electrospun Nanofiber Technology

Macromolecular Materials and Engineering, Volume 311, Issue 6, June 2026.
A semi‐automated approach for early prenatal diagnosis is developed for low‐cellularity samples from coelocentesis by exploiting biotin/streptavidin interaction to functionalize electrospun mats with antibodies. With potential microfluidic integration, the resulting platform enables fetal cell capture, offering a strategy toward improved efficiency and
Emanuela Muscolino, Anna Barbara Di Stefano, Santina Acuto, Clelia Dispenza   +3 more
wiley   +1 more source

The Role of the Ecto-Nucleotidases CD73 and CD39 in Chemo- and Immunotherapy. [PDF]

Cancers (Basel)
Mucha PT, Brahmachari A, Frańczak MA, Tomczyk M, Kutryb-Zając B, Koszałka P, Giovannetti E, Peters GJ.   +7 more
europepmc   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

High CD73 Expression Is Associated with Poor Prognosis in Biliary Tract Cancer Through Reduced Stromal Tumor-Infiltrating Lymphocytes. [PDF]

Cancers (Basel)
Shiratori S, Kawakubo K, Hatanaka KC, Kobayashi T, Konishi T, Shinomiya Y, Oda S, Nozawa S, Yonemura H, Sugiura R, Harada K, Nakanishi Y, Noji T, Tanaka S, Hirano S, Kuwatani M, Hatanaka Y, Sakamoto N.   +17 more
europepmc   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source