Results 201 to 210 of about 36,481 (278)

Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors. [PDF]

Angew Chem Int Ed Engl
Dobelmann C, Schmies CC, Rolshoven GW, Scortichini M, Wagner S, Isaak A, Idris RM, Dabel J, Grey L, Losenkova K, Moschütz S, Hroub HA, Keim A, Höppner S, Sandholm J, Boström P, Hollmén M, Sträter N, Hermann S, Yegutkin GG, Jacobson KA, Schelhaas S, Müller CE, Junker A.   +23 more
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunity. [PDF]

Oncoimmunology
Saavedra-Almarza J, Gouët S, Malgue F, Bascuñan C, Hernández-Oliveras A, De la Rosa J, Reyes-Alvarez J, Villaman C, Corrales-Bermúdez J, Castañeda J, García-Gómez M, Martin AJM, Lladser Á, Rosemblatt M, Bono MR, Sauma D.   +15 more
europepmc   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Synergistic Inhibition of Angiogenesis and Tumor Progression by CD73 Inhibitor and Menstrual Blood Stem Cell-Derived Exosomes via miR-422a Upregulation in HER2-Positive Breast Cancer. [PDF]

Cancer Manag Res
Iravani NJ, Majidzadeh-A K, Arab S, Zarinfam S, Hasannejad F.   +4 more
europepmc   +1 more source

The Tumor Immune Microenvironment in Endometrial Cancer: Composition, Molecular Subtypes, and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye, Yashi Shi, Alexander Mustea, Xiaodan Mao, Pengming Sun   +4 more
wiley   +1 more source

Sym024 Interacts with a Unique Epitope on the CD73 Homodimer, Favoring Effective Bivalent Binding to Improve Anti-PD-1 Therapy. [PDF]

Clin Cancer Res
Jakobsen JS, Grandal MM, Hansen RW, Bansia H, Armbruster E, Theret I, Skartved NJØ, Hald R, Melander MC, Worsaae A, Riva M, Reckzeh K, Vuillard L, Lantto J, des Georges A, Fröhlich C.   +15 more
europepmc   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

CD73 expression as a resistance mechanism in advanced <i>EGFR-</i>mutated non-small cell lung cancer. [PDF]

Front Oncol
Eide IJZ, Dyrbekk APH, Bisha I, Haberichter T, Lakis S, Chan J, Lewis A, Martin P, Cooper ZA, Brustugun OT.   +9 more
europepmc   +1 more source

Ultrathin MnO2‐PEG‐PD‐L1 Nanosheets Enable Tumor Microenvironment Modulation and NIR‐II Photothermal Immunotherapy for Durable Control of Lung Cancer and Postoperative Recurrence

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma, Lingxi Zhu, Yingran Shen, Yue Liu, Hugang Liu, Kunpeng Zhang, Chao Jiang   +6 more
wiley   +1 more source