Results 1 to 10 of about 34,844 (152)

Expression of unique sets of GPI-linked proteins by different primary neurons in vitro. [PDF]

Journal of Cell Biology, 1992
We have surveyed the proteins expressed at the surface of different primary neurons as a first step in elucidating how axons regulate their ensheathment by glial cells. We characterized the surface proteins of dorsal root ganglion neurons, superior cervical ganglion neurons, and cerebellar granule cells which are myelinated, ensheathed but unmyelinated,
Michael P Lisanti, James L Salzer
exaly   +3 more sources

O-mannosylation of misfolded ER proteins promotes ERAD [PDF]

The EMBO Journal
Protein quality control (PQC) in the secretory pathway, a process critically linked to numerous human diseases, begins in the endoplasmic reticulum (ER) and involves ER-associated degradation (ERAD) of terminally misfolded proteins.
Leticia Lemus, Hadar Meyer, Ana I Rodríguez-Rosado, Maya Schuldiner, Veit Goder   +4 more
doaj   +2 more sources

Elongation of Axolotl Tailbud Embryos Requires GPI-Linked Proteins and Organizer-Induced, Active, Ventral Trunk Endoderm Cell Rearrangements

Developmental Biology, 2000
Application of phosphatidylinositol-specific phospholipase C to early tailbud stage axolotl embryos reveals that a specific subset of morphogenetic movements requires glycosylphosphatidylinositol (GPI)-linked cell-surface proteins. These include pronephric duct extension, "gill bulge" formation, and embryonic elongation along the anteroposterior axis ...
Malcolm S Steinberg
exaly   +3 more sources

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor [PDF]

Nature, 1997
Glial-cell-line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF mediates its actions through a multicomponent receptor system composed of a ligand-binding glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR ...
R D, Klein, D, Sherman, W H, Ho, D, Stone, G L, Bennett, B, Moffat, R, Vandlen, L, Simmons, Q, Gu, J A, Hongo, B, Devaux, K, Poulsen, M, Armanini, C, Nozaki, N, Asai, A, Goddard, H, Phillips, C E, Henderson, M, Takahashi, A, Rosenthal   +19 more
openaire   +2 more sources

A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model. [PDF]

PLoS ONE, 2017
Mutations in genes involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis underlie a group of congenital syndromes characterized by severe neurodevelopmental defects.
Xuan Yuan, Zhe Li, Andrea C Baines, Eleni Gavriilaki, Zhaohui Ye, Zhexing Wen, Evan M Braunstein, Leslie G Biesecker, Linzhao Cheng, Xinzhong Dong, Robert A Brodsky   +10 more
doaj   +1 more source

Glycosylphosphatidylinositol-Anchor Synthesis in Plants: A Glycobiology Perspective

Frontiers in Plant Science, 2020
More than 200 diverse secretory proteins from Arabidopsis thaliana carry a glycosylphosphatidylinositol (GPI) lipid anchor covalently attached to their carboxyl-terminus.
Gernot Beihammer, Daniel Maresch, Friedrich Altmann, Richard Strasser   +3 more
doaj   +1 more source

N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells. [PDF]

PLoS ONE, 2011
The cellular prion protein (PrP(C)) plays a fundamental role in prion disease. PrP(C) is a glycosylphosphatidylinositol (GPI)-anchored protein with two variably occupied N-glycosylation sites. In general, GPI-anchor and N-glycosylation direct proteins to
Berta Puig, Hermann C Altmeppen, Dana Thurm, Markus Geissen, Catharina Conrad, Thomas Braulke, Markus Glatzel   +6 more
doaj   +1 more source

Dynamics and Interactions of GPI-Linked lynx1 Protein with/without Nicotinic Acetylcholine Receptor in Membrane Bilayers [PDF]

The Journal of Physical Chemistry B, 2020
Nicotinic acetylcholine receptors (nAChRs) participate in diverse biological processes, such as mood, learning, and addiction. Glycosylphosphatidylinositol-linked lynx1 is an allosteric modulator of nAChR function, including shifts in agonist sensitivity, reduced desensitization, and slower recovery from desensitization.
Chuqiao Dong, Nathan R. Kern, Kristin R. Anderson, X. Frank Zhang, Julie M. Miwa, Wonpil Im   +5 more
openaire   +2 more sources

Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting [PDF]

Journal of Extracellular Vesicles, 2016
Background: Extracellular vesicles (EVs) are attractive candidate drug delivery systems due to their ability to functionally transport biological cargo to recipient cells.
Sander A. A. Kooijmans, Clara Gómez Aleza, Steve R. Roffler, Wouter W. van Solinge, Pieter Vader, Raymond M. Schiffelers   +5 more
doaj   +1 more source

Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis. [PDF]

PLoS Genetics, 2015
Glycosylphosphatidylinositol (GPI) is a post-translational modification resulting in the attachment of modified proteins to the outer leaflet of the plasma membrane.
Yemima Budirahardja, Thang Dinh Doan, Ronen Zaidel-Bar   +2 more
doaj   +1 more source