Results 1 to 10 of about 1,574 (145)

Glycosylphosphatidylinositols: More than just an anchor?

Communicative and Integrative Biology, 2016
There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Clive Bate
exaly   +2 more sources

Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides [PDF]

ACS Chemical Biology, 2021
The attachment of proteins to the cell membrane using a glycosylphosphatidylinositol (GPI) anchor is a ubiquitous process in eukaryotic cells. Deficiencies in the biosynthesis of GPIs and the concomitant production of GPI-anchored proteins lead to a series of rare and complicated disorders associated with inherited GPI deficiencies (IGDs) in humans ...
Paula A. Guerrero, Yoshiko Murakami, Ankita Malik, Peter H. Seeberger, Taroh Kinoshita, Daniel Varón Silva   +5 more
openaire   +3 more sources

Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages. [PDF]

PLoS ONE, 2014
Glycosylphosphatidylinositols (GPIs) from several protozoan parasites are thought to elicit a detrimental stimulation of the host innate immune system aside their main function to anchor surface proteins.
Sebastian Niehus, Terry K Smith, Nahid Azzouz, Marco A Campos, Jean-François Dubremetz, Ricardo T Gazzinelli, Ralph T Schwarz, Françoise Debierre-Grockiego   +7 more
doaj   +1 more source

Insulin-mimicking bioactivities of acylated inositol glycans in several mouse models of diabetes with or without obesity. [PDF]

PLoS ONE, 2014
Insulin-mimetic species of low molecular weight are speculated to mediate some intracellular insulin actions. These inositol glycans, which are generated upon insulin stimulation from glycosylphosphatidylinositols, might control the activity of a ...
Susumu Suzuki, Chitose Suzuki, Yoshinori Hinokio, Yasushi Ishigaki, Hideki Katagiri, Makoto Kanzaki, Viatcheslav N Azev, Nilanjana Chakraborty, Marc d'Alarcao   +8 more
doaj   +1 more source

Trypanosome Glycosylphosphatidylinositol Biosynthesis [PDF]

The Korean Journal of Parasitology, 2009
Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins.
Yeonchul, Hong, Taroh, Kinoshita
openaire   +2 more sources

Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage

Biology, 2015
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neurons.
Ewan West, Craig Osborne, William Nolan, Clive Bate   +3 more
doaj   +1 more source

Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes

Orphanet Journal of Rare Diseases, 2020
Background Defects in the glycosylphosphatidylinositol (GPI) biosynthesis pathway can result in a group of congenital disorders of glycosylation known as the inherited GPI deficiencies (IGDs).
Leigh C. Carmody, Hannah Blau, Daniel Danis, Xingman A. Zhang, Jean-Philippe Gourdine, Nicole Vasilevsky, Peter Krawitz, Miles D. Thompson, Peter N. Robinson   +8 more
doaj   +1 more source

A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry Biogenesis and Virulence

mSphere, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Nathan M. Chasen, Beejan Asady, Leandro Lemgruber, Rossiane C. Vommaro, Jessica C. Kissinger, Isabelle Coppens, Silvia N. J. Moreno   +6 more
doaj   +1 more source

Alkylacylglycerolipid domain of GPI molecules of Leishmania is responsible for inhibition of PKC-mediated c-fos expression

Journal of Lipid Research, 2003
Glycosylphosphatidylinositols (GPIs) are the most abundant molecules present in the membranes of the parasitic protozoa Leishmania responsible for multiple forms of leishmaniasis.
Mamta Chawla, Ram A. Vishwakarma
doaj   +1 more source

Glycosylphosphatidylinositol Anchors from Galactomannan and GPI-Anchored Protein Are Synthesized by Distinct Pathways in Aspergillus fumigatus

Journal of Fungi, 2018
Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall polymers.
Jizhou Li, Isabelle Mouyna, Christine Henry, Frédérique Moyrand, Christian Malosse, Julia Chamot-Rooke, Guilhem Janbon, Jean-Paul Latgé, Thierry Fontaine   +8 more
doaj   +1 more source