Glycosylphosphatidylinositols: More than just an anchor? [PDF]
Communicative and Integrative Biology, 2016 There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Clive Bate
exaly +4 more sources
Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage [PDF]
Biology, 2015 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neurons.
Ewan West +3 more
doaj +4 more sources
A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of
mSphere, 2017 Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Nathan M. Chasen +6 more
doaj +4 more sources
The GPI sidechain of Toxoplasma gondii inhibits parasite pathogenesis [PDF]
mBioGlycosylphosphatidylinositols (GPIs) are highly conserved anchors for eukaryotic cell surface proteins. The apicomplexan parasite, Toxoplasma gondii, is a widespread intracellular parasite of warm-blooded animals whose plasma membrane is covered with GPI-
Julia A. Alvarez +13 more
doaj +2 more sources
Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages. [PDF]
PLoS ONE, 2014 Glycosylphosphatidylinositols (GPIs) from several protozoan parasites are thought to elicit a detrimental stimulation of the host innate immune system aside their main function to anchor surface proteins.
Sebastian Niehus +7 more
doaj +1 more source
Insulin-mimicking bioactivities of acylated inositol glycans in several mouse models of diabetes with or without obesity. [PDF]
PLoS ONE, 2014 Insulin-mimetic species of low molecular weight are speculated to mediate some intracellular insulin actions. These inositol glycans, which are generated upon insulin stimulation from glycosylphosphatidylinositols, might control the activity of a ...
Susumu Suzuki +8 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2020 Background Defects in the glycosylphosphatidylinositol (GPI) biosynthesis pathway can result in a group of congenital disorders of glycosylation known as the inherited GPI deficiencies (IGDs).
Leigh C. Carmody +8 more
doaj +1 more source
Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß [PDF]
, 2017 Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2) to ...
Bate, C
core +3 more sources
Journal of Lipid Research, 2003 Glycosylphosphatidylinositols (GPIs) are the most abundant molecules present in the membranes of the parasitic protozoa Leishmania responsible for multiple forms of leishmaniasis.
Mamta Chawla, Ram A. Vishwakarma
doaj +1 more source
Cellules natural killer et immunité innée contre le paludisme [PDF]
, 2006 La réponse immunitaire dirigée contre Plasmodium falciparum (Pf), agent responsable du paludisme chez l’homme, est le résultat de plusieurs milliers d’années de co-évolution entre le parasite et son hôte.
Baratin, Myriam +3 more
core +1 more source