Results 1 to 10 of about 768 (101)
GPIomics: global analysis of glycosylphosphatidylinositol‐anchored molecules of Trypanosoma cruzi
Molecular Systems Biology, 2009 Glycosylphosphatidylinositol (GPI) anchoring is a common, relevant posttranslational modification of eukaryotic surface proteins. Here, we developed a fast, simple, and highly sensitive (high attomole‐low femtomole range) method that uses liquid ...
Igor C Almeida +2 more
exaly +2 more sources
Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes
mSphere, 2022 A hallmark of eukaryotic cells is the ability to form a secretory pathway connecting many intracellular compartments. In the early secretory pathway, coated protein complex II (COPII)-coated vesicles mediate the anterograde transport of newly synthesized
Mohamed Sharif, James D. Bangs
doaj +1 more source
Biosynthesis and biology of mammalian GPI-anchored proteins [PDF]
Open Biology, 2020 At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus.
Taroh Kinoshita
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Glycosylphosphatidylinositol-Anchor Synthesis in Plants: A Glycobiology Perspective
Frontiers in Plant Science, 2020 More than 200 diverse secretory proteins from Arabidopsis thaliana carry a glycosylphosphatidylinositol (GPI) lipid anchor covalently attached to their carboxyl-terminus.
Gernot Beihammer +3 more
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Turnover of Variant Surface Glycoprotein in
mBio, 2021 African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific phospholipase C (
Paige Garrison +9 more
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GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets
Frontiers in Oncology, 2020 With millions of cases diagnosed annually and high economic burden to cover expensive costs, cancer is one of the most difficult diseases to treat due to late diagnosis and severe adverse effects from conventional therapy.
Nada H. Hussein +2 more
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New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies
Antioxidants, 2022 Selective regional iron accumulation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. The underlying mechanisms of neuronal iron dyshomeostasis have been studied, mainly in a gene-by-gene ...
Daniel A. Bórquez +3 more
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Major Surface Antigens in Zoonotic Babesia
Pathogens, 2022 Human babesiosis results from a combination of tick tropism for humans, susceptibility of a host to sustain Babesia development, and contact with infected ticks.
Stephane Delbecq
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Frontiers in Genetics, 2020 Glycosylphosphatidylinositol (GPI) is a membrane anchor for cell surface proteins. Inherited GPI deficiencies are a new subclass of congenital disorders of glycosylation.
Lily Zhang +6 more
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Journal of Lipid Research, 2016 Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine ...
Taroh Kinoshita, Morihisa Fujita
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