An Unusual Carbohydrate Conformation is Evident in Moraxella catarrhalis Oligosaccharides [PDF]
Molecules, 2015 Oligosaccharide structures derived from the lipooligosaccharide of M. catarrhalis show that the highly branched glucose-rich inner core of the oligosaccharide has an altered conformation compared to the most truncated tetra-glucose-Kdo lgt1/4Δ ...
Martin Frank +4 more
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Bivalent Inhibitors of Mannose-Specific Bacterial Adhesion: A Xylose-Based Conformational Switch to Control Glycoligand Distance [PDF]
MoleculesFunctional glycomimetics is suited to study the parameters of carbohydrate recognition that forms the basis of glycobiology. It is particularly attractive when a glycoligand allows for the investigation of two different states, such as varying distance ...
Sven Ole Jaeschke +2 more
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Shape: automatic conformation prediction of carbohydrates using a genetic algorithm [PDF]
Journal of Cheminformatics, 2009 Background Detailed experimental three dimensional structures of carbohydrates are often difficult to acquire. Molecular modelling and computational conformation prediction are therefore commonly used tools for three dimensional structure studies ...
Rosen Jimmy +2 more
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Targeting galectin-3 in cancer by novel and unique inhibitors of non-carbohydrate origin [PDF]
Molecular MedicineThe galactoside-binding galectin-3 is a multi-mode promoter in a broad range of cancers, as well as in the pathogenesis of inflammation and fibrosis-associated diseases. It is currently a hotly pursued therapeutic target in those disease areas.
Paulina Sindrewicz-Goral +8 more
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Framework-mediated binding of foreign and self-glycans by IGHV4–34 antibodies [PDF]
Frontiers in ImmunologyCold agglutinin disease is an autoimmune condition characterised by expression of self-reactive antibodies to I/i carbohydrate blood group antigens (polymers of N-acetyllactosamine or ‘LacNAc’ units) resulting in anaemia through the agglutination and ...
David B. Langley +9 more
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Influence of Trp flipping on carbohydrate binding in lectins. An example on Aleuria aurantia lectin AAL. [PDF]
PLoS ONE, 2017 Protein-carbohydrate interactions are very often mediated by the stacking CH-π interactions involving the side chains of aromatic amino acids such as tryptophan (Trp), tyrosine (Tyr) or phenylalanine (Phe).
Josef Houser +6 more
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Carbohydrate Structure Database oligosaccharide conformation tool
Glycobiology, 2022 Abstract Population analysis in terms of glycosidic torsion angles is frequently used to reveal preferred conformers of glycans. However, due to high structural diversity and flexibility of carbohydrates, conformational characterization of complex glycans can be a challenging task.
Sofya I Scherbinina +2 more
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Glycopolymer-Wrapped Carbon Nanotubes Show Distinct Interaction of Carbohydrates With Lectins
Frontiers in Chemistry, 2022 Glyconanomaterials with unique nanoscale property and carbohydrate functionality show vast potential in biological and biomedical applications. We investigated the interactions of noncovalent complexes of single-wall carbon nanotubes that are wrapped by ...
Ana M. DiLillo +4 more
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Solvent interactions determine carbohydrate conformation [PDF]
Proceedings of the National Academy of Sciences, 2001 The relationship between the three-dimensional structures of oligosaccharides and polysaccharides and their biological properties has been the focus of many recent studies. The overall conformation of an oligosaccharide depends primarily on the orientation of the torsion angles (φ, ψ, and ω) between glycosyl residues. Numerous experimental
K N, Kirschner, R J, Woods
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Biomolecules, 2020 Glycosaminoglycans (GAGs) are linear, structurally diverse, conformationally complex carbohydrate polymers that may contain up to 200 monosaccharides.
Elizabeth K. Whitmore +3 more
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