Carbohydrate- and Conformation-dependent Cargo Capture for ER-Exit [PDF]
Molecular Biology of the Cell, 2005 Some secretory proteins leave the endoplasmic reticulum (ER) by a receptor-mediated cargo capture mechanism, but the signals required for the cargo-receptor interaction are largely unknown. Here, we describe a novel targeting motif that is composed of a high-mannose type oligosaccharide intimately associated with a surface-exposed peptide β-hairpin ...
Appenzeller-Herzog, C. +5 more
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Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure. [PDF]
Biophys J, 2014 Globotriaosylceramide (Gb3), a glycosphingolipid found in the plasma membrane of animal cells, is the endocytic receptor of the bacterial Shiga toxin.
Watkins EB +7 more
europepmc +2 more sources
Exploring Carbohydrate Conformation and Linkages through Molecular Modelling
, 2023 Carbohydrates, essential organic molecules in living cells, have diverse applications in medicine, agriculture, biotechnology, material design, and industry.
Keuls, Julia +3 more
core +3 more sources
Solvent interactions determine carbohydrate conformation [PDF]
Proceedings of the National Academy of Sciences, 2001 The relationship between the three-dimensional structures of oligosaccharides and polysaccharides and their biological properties has been the focus of many recent studies. The overall conformation of an oligosaccharide depends primarily on the orientation of the torsion angles (φ, ψ, and ω) between glycosyl residues.
K N, Kirschner, R J, Woods
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Carbohydrate Structure Database oligosaccharide conformation tool
Glycobiology, 2022 Abstract Population analysis in terms of glycosidic torsion angles is frequently used to reveal preferred conformers of glycans. However, due to high structural diversity and flexibility of carbohydrates, conformational characterization of complex glycans can be a challenging task.
Sofya I Scherbinina +2 more
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The effect of neutral sugar distribution on the dilute solution conformation of sugar beet pectin [PDF]
, 2012 A partially degraded sugar beet pectin (C) was found to be heterogeneous in composition with neutral sugar-rich fractions of both high and low hydrodynamic radii. A neutral sugar-poor fraction was found at intermediate hydrodynamic radii.
Morris, Gordon +5 more
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Macromolecular conformation of chitosan in dilute solution: A new global hydrodynamic approach [PDF]
, 2009 Chitosans of different molar masses were prepared by storing freshly prepared samples for up to 6 months at either 4, 25 or 40 °C. The weight-average molar masses, Mw and intrinsic viscosities, [η] were then measured using size exclusion chromatography
Adams, G. G. +4 more
core +1 more source
A glycoconjugate of Haemophilus influenzae Type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate [PDF]
, 2016 Three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution.
Harding, Stephen E. +15 more
core +1 more source
Crystal structures of three bicyclic carbohydrate derivatives
Acta Crystallographica Section E: Crystallographic Communications, 2016 The title compounds, [(1R,3R,4R,5R,6S)-4,5-bis(acetyloxy)-7-oxo-2-oxabicyclo[4.2.0]octan-3-yl]methyl acetate, C14H18O8, (I), [(1S,4R,5S,6R)-5-acetyloxy-7-hydroxyimino-2-oxobicyclo[4.2.0]octan-4-yl acetate, C11H15NO6, (II), and [(3aR,5R,6R,7R,7aS)-6,7-bis(
Uwe Schilde +3 more
doaj +1 more source
Automated Glycan Assembly to Study Carbohydrate Materials [PDF]
, 2020 This thesis highlights the use of synthetic tailor-made oligo- and polysaccharides to study carbohydrate materials at different levels: chemical structure, conformation, aggregation tendency, and properties.
Yu, Y., Yu, Yang
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