Results 31 to 40 of about 271 (211)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
An Orthogonal ‘Clickable’ Xyloside Scaffold in 4C1 and 1C4 Conformation
MoleculesGlycoclusters are important molecular tools for studying carbohydrate–protein interactions. It is advantageous to derive glycoclusters from carbohydrate-based scaffolds.
Lorenz Pietsch +2 more
doaj +1 more source
Crystal structure of [(2R,3R,4S)-3,4-bis(acetyloxy)-5-iodo-3,4-dihydro-2H-pyran-2-yl]methyl acetate
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C12H15IO7, the 3,4-dihydro-2H-pyran ring is in a distorted half-boat conformation with the atom bearing the acetyloxy group adjacent to the C atom bearing the methylacetate group lying 0.633 (6) Å above the plane of the remaining ...
Julio Zukerman-Schpector +4 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Nature CommunicationsThe human coronavirus HKU1 uses both sialoglycoconjugates and the protein transmembrane serine protease 2 (TMPRSS2) as receptors. Carbohydrate binding leads to the spike protein up conformation required for TMPRSS2 binding, an outcome suggesting a ...
Min Jin +11 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Effects of Altitudinal Gradient on Physicochemical and Rheological Potential of Quinoa Cultivars
Frontiers in Sustainable Food Systems, 2022 The protein, carbohydrate, and fat characteristics of quinoa grains reflect in their techno-functional potential. This aspect has been little studied in quinoa, while some physicochemical and rheological characteristics have been generalized for all ...
Miguel Ángel Garcia-Parra +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Acetyl α-d-2,3,4-triacetyllyxopyranoside
IUCrDataThe structure of the title compound, C13H18O9, has monoclinic (P21) symmetry. It is of interest with respect to stereochemistry and the anomeric effect. Two acetyl subsituents adopt equatorial orientations and two are axial.
Shawn Culver, Jonathan S. Rhoad
doaj +1 more source
Das Kupfertetramminion, ein empfindliches Reagens für CD-Untersuchungen von Kohlenhydraten
CHIMIA, 1973 The circular dichroism spectra of carbohydrate copper tetrammonia solutions allow to get valuable information about the configuration and conformation of sugars.
Wolfgang Voelter +2 more
doaj +1 more source