Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]
PLoS Pathogens, 2014 Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford +4 more
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Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign. [PDF]
PLoS Neglected Tropical Diseases, 2012 Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes ...
Melissa L Sykes +7 more
doaj +2 more sources
Route of inoculation influences Trypanosoma congolense and Trypanosoma brucei brucei virulence in Swiss white mice. [PDF]
PLoS ONE, 2019 Experiments on infections caused by trypanosomes are widely performed in Swiss white mice through various inoculation routes. To better understand the effect of route of trypanosome inoculation on disease outcomes in this model, we characterised the ...
Kariuki Ndungu +8 more
doaj +2 more sources
Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Mottram, Jeremy +3 more
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Molecular Identification of ABC2 Transporter Gene Encode Protein Ngawi Trypanosoma evansi Isolate that suspected resistance to Isometamidium Chloride [PDF]
BIO Web of Conferences, 2021 This study aims to determine the profile of the ABC2 encoding transporter on Trypanosoma evansi (T. evansi) Ngawi isolates, Indonesia, exposed with Isometamidium Chloride (ISM). This study used blood samples of mice containing Trypanosoma evansi that had
Wusahaningtyas Lu’lu’ Sahara +4 more
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Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant [PDF]
, 2006 Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness. T. brucei hexose transporters are unable to transport galactose, which is instead obtained through the epimerization of UDP ...
Turnock, Daniel C. +2 more
core +5 more sources
Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages [PDF]
, 2012 The protozoan parasite Trypanosoma brucei has a complex digenetic lifecycle between a mammalian host and an insect vector, and adaption of its proteome between lifecycle stages is essential to its survival and virulence. We have optimized a procedure for
Urbaniak, Michael +2 more
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The system of genetic exchange in Trypanosoma brucei and other trypanosomatids [PDF]
, 2007 In this chapter, we discuss our current understanding of the systems of genetic exchange in trypanosomatids and the im-pact the recent genome projects have had on this area of research.
Turner, C.M.R., Tait, A., MacLeod, A.
core +5 more sources
Wellcome Open Research, 2022 Background: Trypanosoma brucei is a protozoan parasite and the etiological agent of human and animal African trypanosomiasis. The organism cycles between its mammalian host and tsetse vector.
Michael A. J. Ferguson, Michele Tinti
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Trypanosoma brucei brucei is more pathogenic in rats compared to mice, making rats a better candidate for the relevant research studies [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 Trypanosomosis is an economically important disease that has raised great and diverse kinds of research using different types of animals. Hence, this study is aimed at determining the better laboratory animal between the Swiss albino mice and Wistar ...
Karimat Hussain +4 more
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