Results 1 to 10 of about 75,660 (213)

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]

PLoS Pathogens, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn   +4 more
doaj   +2 more sources

A Role for Janus Cyclohexyl Ring Motifs in Medicinal Chemistry. Incorporation Into G‐Quadruplex Ligands and Anti‐Trypanosoma brucei Activity [PDF]

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Naphthalene diimide (NDI) cores with peripheral fluorocyclohexyl ring systems are explored binding to G‐quadruplex DNA and were also assayed against the Trypanosoma brucei parasite. The most active compound of the series displayed nanomolar activity and suggested electrostatic interactions between the polarized cyclohexane and G‐Quad DNA.
Josephine M. Stewart, Mario Kehler, Vytautas Kuodis, Gary N. Parkinson, Wenqian Chen, Terry K. Smith, Zoë A. E. Waller, David O’Hagan   +7 more
wiley   +2 more sources

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign. [PDF]

PLoS Neglected Tropical Diseases, 2012
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes ...
Melissa L Sykes, Jonathan B Baell, Marcel Kaiser, Eric Chatelain, Sarah R Moawad, Danny Ganame, Jean-Robert Ioset, Vicky M Avery   +7 more
doaj   +2 more sources

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages [PDF]

, 2012
The protozoan parasite Trypanosoma brucei has a complex digenetic lifecycle between a mammalian host and an insect vector, and adaption of its proteome between lifecycle stages is essential to its survival and virulence. We have optimized a procedure for
Urbaniak, Michael, Guther, M. Lucia S., Ferguson, Michael A. J.   +2 more
core   +5 more sources

Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]

, 2014
Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Mottram, Jeremy, Jones, N.G., Coombs, Graham, Proto, William R   +3 more
core   +5 more sources

Molecular Identification of ABC2 Transporter Gene Encode Protein Ngawi Trypanosoma evansi Isolate that suspected resistance to Isometamidium Chloride [PDF]

BIO Web of Conferences, 2021
This study aims to determine the profile of the ABC2 encoding transporter on Trypanosoma evansi (T. evansi) Ngawi isolates, Indonesia, exposed with Isometamidium Chloride (ISM). This study used blood samples of mice containing Trypanosoma evansi that had
Wusahaningtyas Lu’lu’ Sahara, Nuryady Moh Mirza, Firdausy Lintang Winantya, Fahrurrozi Zs Ahmad, Nurcahyo R. Wisnu   +4 more
doaj   +1 more source

The system of genetic exchange in Trypanosoma brucei and other trypanosomatids [PDF]

, 2007
In this chapter, we discuss our current understanding of the systems of genetic exchange in trypanosomatids and the im-pact the recent genome projects have had on this area of research.
Turner, C.M.R., Tait, A., MacLeod, A.
core   +5 more sources

Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant [PDF]

, 2006
Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness. T. brucei hexose transporters are unable to transport galactose, which is instead obtained through the epimerization of UDP ...
Turnock, Daniel C., Ferguson, Michael A. J., Urbaniak, Michael D.   +2 more
core   +5 more sources

Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa

Frontiers in Veterinary Science, 2021
While both human and animal trypanosomiasis continue to present as major human and animal public health constraints globally, detailed analyses of trypanosome wildlife reservoir hosts remain sparse.
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Gerald Zirintunda, Fred Ssempijja, Bridget Buyinza, Khalid J. Alzahrani, Kevin Matama, Helen N. Nakimbugwe, Helen N. Nakimbugwe, Luay Alkazmi, David Onanyang, Paul Bogere, Juma John Ochieng, Saher Islam, Wycliff Matovu, David Paul Nalumenya, Gaber El-Saber Batiha, Lawrence Obado Osuwat, Mahmoud Abdelhamid, Tianren Shen, Tianren Shen, Leonard Omadang, Susan Christina Welburn, Susan Christina Welburn   +23 more
doaj   +1 more source

Visualisation of experimentally determined and predicted protein N-glycosylation and predicted glycosylphosphatidylinositol anchor addition in Trypanosoma brucei. [version 1; peer review: 3 approved]

Wellcome Open Research, 2022
Background: Trypanosoma brucei is a protozoan parasite and the etiological agent of human and animal African trypanosomiasis. The organism cycles between its mammalian host and tsetse vector.
Michael A. J. Ferguson, Michele Tinti
doaj   +1 more source