Results 1 to 10 of about 251,222 (192)

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors. [PDF]

PLoS Neglected Tropical Diseases, 2017
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for three
Antonio C B Burtoloso, Sérgio de Albuquerque, Mark Furber, Juliana C Gomes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, Carlos A Montanari, José Carlos Quilles, Jean F R Ribeiro, Josmar R Rocha   +10 more
doaj   +7 more sources

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents [PDF]

Molecules, 2015
African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally.
Ngozi Justina Nwodo, Akachukwu Ibezim, Fidele Ntie-Kang, Michael Umale Adikwu, Chika John Mbah   +4 more
doaj   +5 more sources

Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives [PDF]

Molecules, 2020
With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields.
Ayanda I. Zulu, Ogunyemi O. Oderinlo, Cuan Kruger, Michelle Isaacs, Heinrich C. Hoppe, Vincent J. Smith, Clinton G. L. Veale, Setshaba D. Khanye   +7 more
doaj   +5 more sources

Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components [PDF]

Molecules, 2019
Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei, is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection.
Thanh Binh Le, Claire Beaufay, Duc Trong Nghiem, Tuan Anh Pham, Marie-Paule Mingeot-Leclercq, Joëlle Quetin-Leclercq   +5 more
doaj   +4 more sources

Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2020
A bioassay-guided phytochemical investigation of propolis samples from Tanzania and Zambia that screened for activity against Trypanosoma brucei has led to the isolation of two novel flavanones with promising antitrypanosomal activity. The compounds were
Samya S. Alenezi, Manal J. Natto, John O. Igoli, Alexander I. Gray, James Fearnley, Hugo Fearnley, Harry P. de Koning, David G. Watson   +7 more
doaj   +8 more sources

Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis [PDF]

Molecules, 2019
Twelve propolis samples from different parts of Libya were investigated for their phytochemical constituents. Ethanol extracts of the samples and some purified compounds were tested against Trypanosoma brucei, Plasmodium falciparum and against two ...
Weam Siheri, Godwin U. Ebiloma, John O. Igoli, Alexander I. Gray, Marco Biddau, Pilaslak Akrachalanont, Samya Alenezi, Mohammad A. Alwashih, RuAngelie Edrada-Ebel, Sylke Muller, Catherine E. Lawrence, James Fearnley, David G. Watson, Harry P. De Koning   +13 more
doaj   +5 more sources

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome. [PDF]

FEBS J
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
von Känel C, Aeschlimann S, Husová M, Oeljeklaus S, Stettler P, Schnaufer A, Warscheid B, Zíková A, Schneider A.   +8 more
europepmc   +3 more sources

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites. [PDF]

Chemistry
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Monfret O, Liu D, Louis M, Rebei S, Urban D, Bourdreux Y, Mouray E, Grellier P, Doisneau G, Guianvarc'h D.   +9 more
europepmc   +2 more sources

Anti-trypanosomal activity of crude root extract of Leptadenia hastata (Pers) decne in Wistar rats infected with Trypanosoma brucei brucei and associated hematological changes [PDF]

Journal of Advanced Veterinary and Animal Research, 2019
Objective: An in vivo study was carried out to evaluate the possible anti-trypanosomal activity of Leptadenia hastata crude root extract with also its associated hematological changes particularly the packed cell volume (PCV) in experimental Trypanosoma ...
Samson Anjikwi Malgwi, Mohammed Kyari Zango, Albert Wulari Mbaya, Gamgong Dennis, Falmata Kyari, Kyari Abba Sanda, Stephen Bitrus Balami, Abwari David Bwala   +7 more
doaj   +2 more sources

Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges. [PDF]

PLoS ONE, 2015
Marine sponge-associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been ...
Cheng Cheng, Lynsey MacIntyre, Usama Ramadan Abdelmohsen, Hannes Horn, Paraskevi N Polymenakou, RuAngelie Edrada-Ebel, Ute Hentschel   +6 more
doaj   +2 more sources