Results 1 to 10 of about 2,622 (160)

Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T.
Lionel Sacconnay, Melissa Angleviel, Giuseppe Marco Randazzo, Marcos Marçal Ferreira Queiroz, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Pierre-Alain Carrupt, Alessandra Nurisso   +7 more
doaj   +1 more source

In vitro trypanocidal activity of solamargine and extracts from Solanum palinacanthum and Solanum lycocarpum of brazilian cerrado

Anais da Academia Brasileira de Ciências, 2013
The present investigation was to evaluate the potential trypanocidal activity of crude ethanolic extract of the fruits of Solanum palinacanthum, Solanum lycocarpum and the glycoalcaloid, solamargine. S. palinacanthum and S.
RAQUEL R.D. MOREIRA, GILMARCIO Z. MARTINS, NATHALIA O. MAGALHAES, ADELIA E. ALMEIDA, ROSEMEIRE C.L.R. PIETRO, FLAVIA A. J. SILVA, REGINA M.B. CICARELLI   +6 more
doaj   +1 more source

2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses

Acta Pharmaceutica, 2020
Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan ...
Serban Georgeta
doaj   +1 more source

Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives

Biomolecules, 2016
There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu, Guanzhong Mao, Leif A. Kirsebom   +2 more
doaj   +1 more source

Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase

Molecules, 2017
Chagas, or American trypanosomiasis, remains an important public health problem in developing countries. In the last decade, trans-sialidase has become a pharmacological target for new anti-Chagas drugs.
Muhammad Kashif, Antonio Moreno-Herrera, Juan Carlos Villalobos-Rocha, Benjamín Nogueda-Torres, Jaime Pérez-Villanueva, Karen Rodríguez-Villar, José Lius Medina-Franco, Peterson de Andrade, Ivone Carvalho, Gildardo Rivera   +9 more
doaj   +1 more source

JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes

Memorias do Instituto Oswaldo Cruz, 2014
Trypanosoma cruzi has a particular cytoskeleton that consists of a subpellicular network of microtubules and actin microfilaments. Therefore, it is an excellent target for the development of new anti-parasitic drugs.
Dylan L Díaz-Chiguer, Francisco Hernández-Luis, Benjamín Nogueda-Torres, Rafael Castillo, Olivia Reynoso-Ducoing, Alicia Hernández-Campos, Javier R Ambrosio   +6 more
doaj   +1 more source

KBE009: A Bestatin-Like Inhibitor of the Trypanosoma cruzi Acidic M17 Aminopeptidase with In Vitro Anti-Trypanosomal Activity. [PDF]

Life (Basel), 2021
González-Bacerio J, Arocha I, Aguado ME, Méndez Y, Marsiccobetre S, Izquierdo M, Rivera DG, Figarella K, Uzcátegui NL.   +8 more
europepmc   +1 more source

Traditional Uses, Pharmacological Efficacy, and Phytochemistry of Moringa peregrina (Forssk.) Fiori. —A Review

Frontiers in Pharmacology, 2018
Moringa is a sole genus of Moringaceae family with 13 species distributed in the tropical and sub-tropical regions. Among them, Moringa peregrina is one of the species which has wide range of traditional, nutritional, industrial, and medicinal values ...
Annadurai Senthilkumar, Noushad Karuvantevida, Luca Rastrelli, Shyam S. Kurup, Abdul J. Cheruth   +4 more
doaj   +1 more source

Trypanocidal potentials of Jatropha curcas L. 1753 leaf extracts and fractions in vivo

Pharmacological Research - Modern Chinese Medicine
Introduction: Trypanosomiasis is a debilitating parasitic disease affecting both humans and animals, leading to substantial economic losses in the livestock sector due to reduced productivity and increased mortality.
Haolat Yusuf, Abdulhakeem Binhambali, Mutiu Olawale Rahmon, Ridwan Bolaji Yusuf, Suleiman Garba Salihu, Barnabas Jarumi Musa   +5 more
doaj   +1 more source

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones

Molecules
2,6-Diaryl-4H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal diarylideneacetones through a prodrug effect.
Thibault Gendron, Don Antoine Lanfranchi, Nicole I. Wenzel, Hripsimée Kessedjian, Beate Jannack, Louis Maes, Sandrine Cojean, Thomas J. J. Müller, Philippe M. Loiseau, Elisabeth Davioud-Charvet   +9 more
doaj   +1 more source