Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae) Atividade anti-tripanosomicida de triterpenes pentacíclicos isolados de Austroplenckia populnea (Celastraceae) [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 2002 Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less ...
Lucienir Pains DUARTE +4 more
doaj +5 more sources
Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]
ChembiochemAll‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
He M +6 more
europepmc +2 more sources
In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense [PDF]
UMYU Journal of Microbiology ResearchThe development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M. +3 more
doaj +2 more sources
Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides [PDF]
Communications ChemistrySets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity.
Brian S. Mantilla +6 more
doaj +2 more sources
Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from Euphorbia abyssinica J.F. Gmel
Plants, 2022 Human African trypanosomiasis is an endemic infectious disease caused by Trypanosoma brucei via the bite of tsetse-fly. Most of the drugs used for the treatment, e.g., Suramin, have shown several problems, including the high level of toxicity ...
Seham S. El-Hawary +7 more
doaj +1 more source
Plants, 2021 Marine halophytes are an outstanding reservoir of natural products and several species have anti-infectious traditional uses. However, reports about their potential use against neglected tropical ailments, such as Chagas disease, are scarce.
Catarina G. Pereira +9 more
doaj +1 more source
Studies of anti-trypanosomal active triterpenoids from some African propolis
, 2012 Strathclyde theses - ask staff. Thesis no. : T13333There is a drastic need for new and improved drugs for parasitic diseases such as African Trypanosomiasis which is a major global health problem with high endemicity in developing countries due to the ...
AlKhalil, Adnan Faysal
openaire +3 more sources
In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones [PDF]
Drug Research, 2018 Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting.
Beteck, Richard M +3 more
openaire +4 more sources
The anti‐Trypanosoma activities of medicinal plants: A systematic review of the literature
Veterinary Medicine and Science, 2022 Background The existing drug treatments for trypanosomiases are limited and suffer from shortcomings due to their toxicity and the emergence of resistant parasites.
Shahin Nekoei +5 more
doaj +1 more source
Anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal plants [PDF]
, 2011 This chapter explores the anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal ...
Gray, Alexander +3 more
core +4 more sources