Results 21 to 30 of about 2,622 (160)

Cinnamoylphenethyl Amides from Possess Anti-Trypanosomal Activity [PDF]

Natural Product Communications, 2012
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC 50 =3.7 μg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides,
Fahimeh Moradi-Afrapoli, Nargues Yassa, Stefanie Zimmermann, Soodabeh Saeidnia, Abbas Hadjiakhoondi, Samad N. Ebrahimi, Matthias Hamburger   +6 more
doaj   +4 more sources

DNA fingerprinting of five Tabebuia species with reference to their anti-trypanosomal activity [PDF]

Pharmaceutical Sciences Asia, 2022
Tabebuia is the largest genus of the Bignoniaceae family, with great importance due to its beautiful decorative flowering trees, as well as, its remarkable biological activities.
Seham El-Hawary, Rabab Mohammed, Marwa Taher, Sameh Fekry AbouZid, Sameh Fekry AbouZid, Elham Amin, Elham Amin   +6 more
doaj   +2 more sources

Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad Rhinella alata (Anura, Bufonidae) [PDF]

Molecules, 2023
Amphibians are widely known as a prolific source of bioactive metabolites. In this work, we isolated and characterized compounds with antiparasitic activity from the oocytes of the toad Rhinella alata collected in Panama.
Candelario Rodriguez, Roberto Ibáñez, Dionisio A. Olmedo, Michelle Ng, Carmenza Spadafora, Armando A. Durant-Archibold, Marcelino Gutiérrez   +6 more
doaj   +2 more sources

Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae) Atividade anti-tripanosomicida de triterpenes pentacíclicos isolados de Austroplenckia populnea (Celastraceae) [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2002
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less ...
Lucienir Pains DUARTE, Sidney Augusto VIEIRA FILHO, Grácia Divina de Fátima SILVA, José Rego de SOUSA, Artur da Silveira PINTO   +4 more
doaj   +5 more sources

Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides [PDF]

Communications Chemistry
Sets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity.
Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright   +6 more
doaj   +2 more sources

Pyridyl-Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi. [PDF]

ChemMedChem
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Barreto ACR, Figueira KL, Azevedo R, Conceição KD, Fiuza LFA, Vianna LDS, Moraes TA, Júdice WAS, Soeiro MNC, Limberger J.   +9 more
europepmc   +2 more sources

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome. [PDF]

FEBS J
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
von Känel C, Aeschlimann S, Husová M, Oeljeklaus S, Stettler P, Schnaufer A, Warscheid B, Zíková A, Schneider A.   +8 more
europepmc   +3 more sources

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites. [PDF]

Chemistry
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Monfret O, Liu D, Louis M, Rebei S, Urban D, Bourdreux Y, Mouray E, Grellier P, Doisneau G, Guianvarc'h D.   +9 more
europepmc   +2 more sources

Trypanosomal MICOS Is Assembled on Non-Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins. [PDF]

Mol Microbiol
The mitochondrial membrane‐shaping machinery MICOS is assembled surprisingly early during the life cycle of Trypanosoma brucei, before the mitochondrion acquires its mature architecture or full respiratory capacity. Our study also identifies two previously uncharacterized proteins associated with MICOS, providing new insight into the early organization
Boudová M, Wagner T, Bílý T, Tesařová M, Benz C, Hashimi H.   +5 more
europepmc   +2 more sources

Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from Euphorbia abyssinica J.F. Gmel

Plants, 2022
Human African trypanosomiasis is an endemic infectious disease caused by Trypanosoma brucei via the bite of tsetse-fly. Most of the drugs used for the treatment, e.g., Suramin, have shown several problems, including the high level of toxicity ...
Seham S. El-Hawary, Rabab Mohammed, Nadia M. Lithy, Sameh Fekry AbouZid, Mostafa A. Mansour, Suliman A. Almahmoud, Bader Huwaimel, Elham Amin   +7 more
doaj   +1 more source