Results 21 to 30 of about 251,222 (192)

In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense [PDF]

UMYU Journal of Microbiology Research
The development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M., Inabo, H. I., Ella, E. E., Okubanjo, O. O.   +3 more
doaj   +3 more sources

Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides [PDF]

Communications Chemistry
Sets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity.
Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright   +6 more
doaj   +2 more sources

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent. [PDF]

Chem Biodivers
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Oliveira ND, Pagotti MC, Paula LAL, Paixão MZ, Albino Dos Santos D, de Freitas RF, Ambrósio SR, Veneziani RCS, Bastos JK, Magalhães LG.   +9 more
europepmc   +2 more sources

Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae) Atividade anti-tripanosomicida de triterpenes pentacíclicos isolados de Austroplenckia populnea (Celastraceae) [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2002
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less ...
Lucienir Pains DUARTE, Sidney Augusto VIEIRA FILHO, Grácia Divina de Fátima SILVA, José Rego de SOUSA, Artur da Silveira PINTO   +4 more
doaj   +5 more sources

Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) [PDF]

Química Nova, 2012
MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D ...
Roberta T. dos Santos, Liliane L. Hiramoto, João Henrique G. Lago, Patrícia Sartorelli, André G. Tempone, Erika G. Pinto   +5 more
doaj   +3 more sources

IN VITRO AND IN VIVO ANTI-TRYPANOSOMAL ACTIVITIES OF METHANOL EXTRACT OF AZADIRACHTA INDICA STEM-BARK [PDF]

African Journal of Traditional, Complementary and Alternative Medicines, 2017
Background: Current chemotherapeutic agents for the treatment of African trypanosomiasis have become largely ineffective, necessitating the search for alternative compounds. The objective of this study was to evaluate in vitro anti-trypanosomal activities of methanol extracts of parts of Azadirachta indica against Trypanosoma brucei rhodesiense ...
Wanzala, Everlyne N, Gikonyo, Nicholas K, Murilla, Grace, Githua, Mercy, Hassanali, Ahmed   +4 more
openaire   +6 more sources

Studies of anti-trypanosomal active triterpenoids from some African propolis [PDF]

, 2012
Strathclyde theses - ask staff. Thesis no. : T13333There is a drastic need for new and improved drugs for parasitic diseases such as African Trypanosomiasis which is a major global health problem with high endemicity in developing countries due to the ...
AlKhalil, Adnan Faysal
openaire   +2 more sources

In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)

Plants, 2021
Marine halophytes are an outstanding reservoir of natural products and several species have anti-infectious traditional uses. However, reports about their potential use against neglected tropical ailments, such as Chagas disease, are scarce.
Catarina G. Pereira, Carolina Borsoi Moraes, Caio H. Franco, Clarissa Feltrin, Raphaël Grougnet, Euzébio Guimarães Barbosa, Michele Panciera, Carlos Roque D. Correia, Maria João Rodrigues, Luísa Custódio   +9 more
doaj   +1 more source

New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities [PDF]

Marine Drugs, 2011
Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis.
Pimentel-Elardo, Sheila M., Buback, Verena, Gulder, Tobias A. M., Bugni, Tim S., Reppart, Jason, Bringmann, Gerhard, Ireland, Chris M., Schirmeister, Tanja, Hentschel, Ute   +8 more
openaire   +7 more sources

In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones [PDF]

Drug Research, 2018
Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting.
Beteck, Richard M, Legoabe, Lesetje J, Isaacs, Michelle, Hoppe, Heinrich C   +3 more
openaire   +4 more sources