Anti-trypanosomal screening of Salvadoran flora. [PDF]
J Nat Med, 2022 Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and in Central America, it is considered one of the four most infectious diseases.
Castillo UG +8 more
europepmc +5 more sources
New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities [PDF]
Marine Drugs, 2011 Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides.
Ute Hentschel +8 more
doaj +9 more sources
Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Trypanosomiasis is a protozoan disease transmitted via Trypanosoma brucei. This study aimed to examine the metabolic profile and anti-trypanosomal effect of methanol extract of Thunbergia grandifolia leaves.
Heba A. S. El-Nashar +12 more
doaj +3 more sources
Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components [PDF]
Molecules, 2019 Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei, is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection.
Thanh Binh Le +5 more
doaj +3 more sources
Anti-Trypanosomal and Antimalarial Properties of Tetralone Derivatives and Structurally Related Benzocycloalkanones [PDF]
Medicina, 2019 Background and objectives: Sleeping sickness and malaria alike are insect-borne protozoan diseases that share overlapping endemic areas in sub-Saharan Africa.
Richard M. Beteck +5 more
doaj +4 more sources
Design, Synthesis, and Evaluation of Novel Anti-Trypanosomal Compounds. [PDF]
Tetrahedron, 2020 Human African trypanosomiasis (HAT) is a deadly neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. During the course of screening a collection of diverse nitrogenous heterocycles, we discovered two novel compounds that ...
Lepovitz LT +6 more
europepmc +5 more sources
Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents [PDF]
Molecules, 2015 African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally.
Ngozi Justina Nwodo +4 more
doaj +5 more sources
Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis [PDF]
Molecules, 2019 Twelve propolis samples from different parts of Libya were investigated for their phytochemical constituents. Ethanol extracts of the samples and some purified compounds were tested against Trypanosoma brucei, Plasmodium falciparum and against two ...
Weam Siheri +13 more
doaj +3 more sources
Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives [PDF]
Molecules, 2020 With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields.
Ayanda I. Zulu +7 more
doaj +3 more sources
Increased Body Exposure to New Anti-Trypanosomal Through Nanoencapsulation [PDF]
Scientific Reports, 2017 Lychnopholide, a lipophilic sesquiterpene lactone, is efficacious in mice at the acute and chronic phases of Chagas disease. Conventional poly-ε-caprolactone (PCL) and long-circulating poly(D,L-lactide)-block-polyethylene glycol (PLA-PEG) nanocapsules ...
Renata Tupinambá Branquinho +7 more
doaj +5 more sources