Results 11 to 20 of about 3,061,970 (186)

Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad Rhinella alata (Anura, Bufonidae). [PDF]

Molecules, 2023
Amphibians are widely known as a prolific source of bioactive metabolites. In this work, we isolated and characterized compounds with antiparasitic activity from the oocytes of the toad Rhinella alata collected in Panama.
Rodriguez C, Ibáñez R, Olmedo DA, Ng M, Spadafora C, Durant-Archibold AA, Gutiérrez M.   +6 more
europepmc   +2 more sources

In vitro anti-trypanosomal effect of ivermectin on Trypanosoma evansi by targeting multiple metabolic pathways. [PDF]

Trop Anim Health Prod, 2022
High cytotoxicity and increasing resistance reports of existing chemotherapeutic agents against T. evansi have raised the demand for novel, potent, and high therapeutic index molecules for the treatment of surra in animals.
Gupta S, Vohra S, Sethi K, Gupta S, Bera BC, Kumar S, Kumar R.   +6 more
europepmc   +2 more sources

Synthesis and biological evaluation of imidamide analogs as selective anti-trypanosomal agents. [PDF]

Bioorg Med Chem, 2022
Human African trypanosomiasis is caused by a protozoan parasite Trypanosoma brucei majorly infecting people living in sub-Saharan Africa. Current limited available treatments suffer from drug resistance, severe adverse effects, low efficacy, and costly ...
Bobba V, Li Y, Afrin M, Dano R, Zhang W, Li B, Su B.   +6 more
europepmc   +2 more sources

Saturated Iso-Type Fatty Acids from the Marine Bacterium Mesoflavibacter zeaxanthinifaciens with Anti-Trypanosomal Potential. [PDF]

Pharmaceuticals (Basel)
Chagas disease is a Neglected Tropical Disease with limited and ineffective therapy. In a search for new anti-trypanosomal compounds, we investigated the potential of the metabolites from the bacteria living in the corals and sediments of the ...
Santos Ferreira DA, de Castro Levatti EV, Santa Cruz LM, Costa AR, Migotto ÁE, Yamada AY, Camargo CH, Christodoulides M, Lago JHG, Tempone AG.   +9 more
europepmc   +2 more sources

Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies. [PDF]

ChemMedChem
Studies have shown that depending on the substitution pattern, microtubule (MT)‐targeting 1,2,4‐triazolo[1,5‐a]pyrimidines (TPDs) can produce different cellular responses in mammalian cells that may be due to these compounds interacting with distinct ...
Lucero B, Francisco KR, Varricchio C, Liu LJ, Yao Y, Brancale A, Brunden KR, Caffrey CR, Ballatore C.   +8 more
europepmc   +2 more sources

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease. [PDF]

Sci Transl Med
The protozoan parasite Trypanosoma cruzi causes Chagas disease, which is among the deadliest parasitic infections in Latin America. Current therapies are toxic and lack efficacy against chronic stage infection thus new drugs are urgently required.
Tulloch LB, Tawell H, Taylor AE, Lima ML, Dawson A, Carvalho S, Wall RJ, Corpas-Lopez V, Dey G, Duggan J, Magalhaes LG, Torrie LS, Frame L, Robinson D, Patterson S, Tinti M, Weaver GW, Robinson WJ, Cal M, Kaiser M, Mäser P, Sjö P, Perry B, Kelly JM, Francisco AF, Bhambra AS, Wyllie S.   +26 more
europepmc   +2 more sources

Sponge-associated sp. RM66 metabolome induction with N-acetylglucosamine: Antibacterial, antifungal and anti-trypanosomal activities. [PDF]

Saudi J Biol Sci, 2021
The marine sponge Amphimedon sp., collected from Hurghada (Egypt) was investigated for its sponge-derived actinomycetes diversity. Nineteen actinomycetes were cultivated and phylogenetically identified using 16S rDNA gene sequencing were carried out. The
Alkhalifah DHM.
europepmc   +2 more sources

Anti-trypanosomal activity and DNA fingerprinting of fifteen Euphorbia species using ISSR and SCoT markers

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary, Nadia M. Lithy, Elham Amin, Sameh F. AbouZid, Rabab Mohammed   +4 more
doaj   +2 more sources

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis. [PDF]

Trop Med Infect Dis, 2020
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs.
Rao SPS, Lakshminarayana SB, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Mäser P, Mottram JC, Barrett MP, Diagana TT.   +13 more
europepmc   +2 more sources

Affinity is an important determinant of the anti-trypanosome activity of nanobodies.

PLoS Neglected Tropical Diseases, 2012
BackgroundThe discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites.
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier   +6 more
doaj   +4 more sources