Results 11 to 20 of about 1,940,104 (187)
Affinity is an important determinant of the anti-trypanosome activity of nanobodies.
PLoS Neglected Tropical Diseases, 2012 BackgroundThe discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites.
Guy Caljon +6 more
doaj +4 more sources
Anti-trypanosomal activities of DNA topoisomerase inhibitors
Acta Tropica, 2005 Only four drugs are available for chemotherapy of human African sleeping sickness with undesirable toxic side effects. The development of new anti-trypanosomal drugs is, therefore, urgently required. In this study, 15 DNA topoisomerase inhibitors, including approved anti-cancer drugs, were tested for in vitro activity against bloodstream forms of ...
Deterding, Alexander +3 more
openaire +4 more sources
Anti-trypanosomal activity of doubly modified salinomycin derivatives [PDF]
European Journal of Medicinal Chemistry, 2019 As a group of biologically active compounds, polyether antibiotics (ionophores) show a broad spectrum of interesting pharmacological properties, ranging from anti-bacterial to anti-cancer activities. There is increasing evidence that ionophores, including salinomycin (SAL), and their semi-synthetic analogues are promising candidates for the development
Michał Antoszczak +4 more
openaire +5 more sources
Anti-trypanosomal activity of secnidazole in vitro and in vivo [PDF]
Tropical Journal of Pharmaceutical Research, 2017 Purpose: To evaluate the anti-trypanosomal effect of secnidazole (SEC) in vitro and in vivo. Methods: The dose-response effect of SEC in Trypanosoma b. brucei infected rats was evaluated in five groups of rats (n = 5). Group A was infected but untreated; B was given diminazene aceturate (DA) (3.5 mg/kg) intraperitoneally, while groups C, D and E ...
Eke, Ifeanyi G +5 more
openaire +4 more sources
Anti-trypanosomal screening of Salvadoran flora. [PDF]
J Nat Med, 2022 AbstractChagas disease is caused by the protozoan parasite Trypanosoma cruzi, and in Central America, it is considered one of the four most infectious diseases. This study aimed to screen the anti-trypanosomal activity of plant species from Salvadoran flora.
Castillo UG +8 more
europepmc +4 more sources
In vitro anti-trypanosomal effects of selected phenolic acids on Trypanosoma brucei. [PDF]
PLoS ONE, 2019 African trypanosomiasis remains a lethal disease to both humans and livestock. The disease persists due to limited drug availability, toxicity and drug resistance, hence the need for a better understanding of the parasite's biology and provision of ...
Cynthia Mmalebna Amisigo +3 more
doaj +2 more sources
TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome. [PDF]
FEBS JProtein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
von Känel C +8 more
europepmc +2 more sources
Anti-trypanosomal Phenolic Derivatives from [PDF]
Natural Product Communications, 2014 Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a ...
Simone dos S. Grecco +7 more
doaj +3 more sources
Synthesis of cyclohexapeptides as antimalarial and anti-trypanosomal agents
Med. Chem. Commun., 2014 Azolic and non-azolic cyclohexapeptides were obtained and/or evaluated as promising antimalarial and/or anti-trypanosomal agents.
S. Peña +11 more
openaire +2 more sources
Design, Synthesis, and Evaluation of Novel Anti-Trypanosomal Compounds. [PDF]
Tetrahedron, 2020 Human African trypanosomiasis (HAT) is a deadly neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. During the course of screening a collection of diverse nitrogenous heterocycles, we discovered two novel compounds that contain the tetracyclic core of the Yohimbine and Corynanthe alkaloids, were potent inhibitors of T ...
Lepovitz LT +6 more
europepmc +4 more sources