Results 21 to 30 of about 3,061,970 (186)

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors. [PDF]

PLoS Neglected Tropical Diseases, 2017
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for three
Antonio C B Burtoloso, Sérgio de Albuquerque, Mark Furber, Juliana C Gomes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, Carlos A Montanari, José Carlos Quilles, Jean F R Ribeiro, Josmar R Rocha   +10 more
doaj   +2 more sources

Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: an individual patient data meta-analysis of two proof of concept trials

medRxiv
Background The current antiparasitic treatment for chronic Chagas disease of 8 weeks daily benznidazole or nifurtimox is poorly tolerated and reaches only a small minority of those with chronic infections.
Watson JA, Cruz C, Barreira F, Forsyth C, Schijman A, Peploe R, Assmus F, Naylor C, Lee J, Mehra S, Tarning J, Torrico F, Gascon J, Ortiz L, Ribeiro I, Sosa-Estani S, Tipple C, Hugonnet S, Guérin PJ, Fraisse L, Pinazo M, White NJ.   +21 more
europepmc   +2 more sources

Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model. [PDF]

PLoS One, 2020
We assessed the virulence and anti-trypanosomal drug sensitivity patterns of Trypanosoma brucei rhodesiense (Tbr) isolates in the Kenya Agricultural and Livestock Research Organization-Biotechnology Research Institute (KALRO-BioRI) cryobank. Specifically,
Ndung'u K, Murilla GA, Thuita JK, Ngae GN, Auma JE, Gitonga PK, Thungu DK, Kurgat RK, Chemuliti JK, Mdachi RE.   +9 more
europepmc   +2 more sources

Anti-trypanosomal Phenolic Derivatives from [PDF]

Natural Product Communications, 2014
Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a ...
Simone dos S. Grecco, Maria Júlia P. Félix, João Henrique G. Lago, Érika G. Pinto, André G. Tempone, Paulete Romoff, Marcelo José P. Ferreira, Patricia Sartorelli   +7 more
doaj   +3 more sources

Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2020
A bioassay-guided phytochemical investigation of propolis samples from Tanzania and Zambia that screened for activity against Trypanosoma brucei has led to the isolation of two novel flavanones with promising antitrypanosomal activity. The compounds were
Samya S. Alenezi, Manal J. Natto, John O. Igoli, Alexander I. Gray, James Fearnley, Hugo Fearnley, Harry P. de Koning, David G. Watson   +7 more
doaj   +2 more sources

Anti-trypanosomal activity of doubly modified salinomycin derivatives. [PDF]

European Journal of Medicinal Chemistry, 2019
As a group of biologically active compounds, polyether antibiotics (ionophores) show a broad spectrum of interesting pharmacological properties, ranging from anti-bacterial to anti-cancer activities.
M. Antoszczak, D. Steverding, Michał Sulik, J. Janczak, Adam Huczyński   +4 more
semanticscholar   +4 more sources

DNA fingerprinting of five Tabebuia species with reference to their anti-trypanosomal activity [PDF]

Pharmaceutical Sciences Asia, 2022
Tabebuia is the largest genus of the Bignoniaceae family, with great importance due to its beautiful decorative flowering trees, as well as, its remarkable biological activities.
Seham El-Hawary, Rabab Mohammed, Marwa Taher, Sameh Fekry AbouZid, Sameh Fekry AbouZid, Elham Amin, Elham Amin   +6 more
doaj   +2 more sources

Anti-trypanosomal, anti-inflammatory, and neuroprotective effects of Cichorium intybus sesquiterpene lactones in experimental Trypanosoma evansi infection. [PDF]

Sci Rep
Trypanosoma evansi is an important protozoan pathogen affecting various animal species particularly camels and horses, leading to significant economic losses. The ineffective control of T.
Sawerus MG, Kamel HH, Ahmed WMS, Abdel-Shafy S, El Amir D, Mahdi EA, Ibrahim MA, Shehata O.   +7 more
europepmc   +2 more sources

Nitrofurylsemicarbazone Rhenium and Ruthenium Complexes as Anti-trypanosomal Agents

European Journal of Medicinal Chemistry, 2006
Rhenium and ruthenium complexes of the type [Re(V)OCl(2)(PPh(3))L] and [Ru(II)Cl(2)(DMSO)(2)L], where L are 5-nitrofurylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining the recognized biological activity of these metals and the trypanocidal activity of the free ligands.
Dinorah Gambino, Mercedes Gonzalez, Lucia Otero   +2 more
exaly   +5 more sources

Macrocyclic skeletal modification approach to the anti-trypanosomal macrolides, actinoallolides.

Chemical Communications
Herein, we report the construction of 16-membered macrocycles that were designed as intermediates toward the unified synthesis of actinoallolides. Key to our synthesis was the use of Mitsunobu macrocyclization, followed by a sequence of Birch reduction ...
Goh Sennari, Akito Watanabe, Takanori Ōno, Jun Oshita, Yoshihiko Noguchi, T. Hirose, Toshiaki Sunazuka   +6 more
semanticscholar   +3 more sources