Results 21 to 30 of about 3,031 (126)
EUCALYPTUS OIL NANOEMULSION: EVALUATION OF IN VITRO ACTIVITY AGAINST TRYPANOSOMA BRUCEI [PDF]
Zagazig Journal of Pharmaceutical SciencesBackground: Natural products and their secondary metabolites are a good source of pharmacologically active constituents and have been widely developed into modern medicines.
Emmanuel Maduabuchi Uronnachi +4 more
doaj +1 more source
Molecules, 2020 Neglected parasitic diseases remain a major public health issue worldwide, especially in tropical and subtropical areas. Human parasite diversity is very large, ranging from protozoa to worms.
Liwen Feng +12 more
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TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome. [PDF]
FEBS JProtein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
von Känel C +8 more
europepmc +2 more sources
Anti-trypanosomal Phenolic Derivatives from
Natural Product Communications, 2014 Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a ...
Simone dos S. Grecco +7 more
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Beni-Suef University Journal of Basic and Applied Sciences, 2021 Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary +4 more
doaj +1 more source
Affinity is an important determinant of the anti-trypanosome activity of nanobodies.
PLoS Neglected Tropical Diseases, 2012 BackgroundThe discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites.
Guy Caljon +6 more
doaj +1 more source
Hinokinin, an Emerging Bioactive Lignan
Molecules, 2014 Hinokinin is a lignan isolated from several plant species that has been recently investigated in order to establish its biological activities. So far, its cytotoxicity, its anti-inflammatory and antimicrobial activities have been studied.
Maria Carla Marcotullio +2 more
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DNA fingerprinting of five Tabebuia species with reference to their anti-trypanosomal activity [PDF]
Pharmaceutical Sciences Asia, 2022 Tabebuia is the largest genus of the Bignoniaceae family, with great importance due to its beautiful decorative flowering trees, as well as, its remarkable biological activities.
Seham El-Hawary +6 more
doaj +1 more source
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. [PDF]
PLoS Neglected Tropical Diseases, 2018 Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the
Eva Doleželová +9 more
doaj +1 more source
Cinnamoylphenethyl Amides from Possess Anti-Trypanosomal Activity
Natural Product Communications, 2012 A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC 50 =3.7 μg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides,
Fahimeh Moradi-Afrapoli +6 more
doaj +1 more source