Results 31 to 40 of about 3,061,970 (186)
Mechanism of action and implication of naphthoquinone as potent anti-trypanosomal drugs.
Current Topics in Medicinal Chemistry, 2022 Naphthoquinone is a heterocyclic moiety whose natural derivatives are present as bioactive compounds in many plants and have stimulated a resurgence of interest in the past decades due to their wide range of pharmacological activities.
R. Rani +4 more
semanticscholar +4 more sources
In vitro anti-trypanosomal effects of selected phenolic acids on Trypanosoma brucei. [PDF]
PLoS ONE, 2019 African trypanosomiasis remains a lethal disease to both humans and livestock. The disease persists due to limited drug availability, toxicity and drug resistance, hence the need for a better understanding of the parasite's biology and provision of ...
Cynthia Mmalebna Amisigo +3 more
doaj +2 more sources
Aryl ureas represent a new class of anti-trypanosomal agents [PDF]
Chemistry and Biology, 2000 The trypanosomal diseases including Chagas' disease, African sleeping sickness and Nagana have a substantial impact on human and animal health worldwide. Classes of effective therapeutics are needed owing to the emergence of drug resistance as well as the toxicity of existing agents.
Conor Caffrey +2 more
exaly +3 more sources
Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from Euphorbia abyssinica J.F. Gmel
Plants, 2022 Human African trypanosomiasis is an endemic infectious disease caused by Trypanosoma brucei via the bite of tsetse-fly. Most of the drugs used for the treatment, e.g., Suramin, have shown several problems, including the high level of toxicity ...
Seham S. El-Hawary +7 more
doaj +1 more source
The anti‐Trypanosoma activities of medicinal plants: A systematic review of the literature
Veterinary Medicine and Science, 2022 Background The existing drug treatments for trypanosomiases are limited and suffer from shortcomings due to their toxicity and the emergence of resistant parasites.
Shahin Nekoei +5 more
doaj +1 more source
Plants, 2021 Marine halophytes are an outstanding reservoir of natural products and several species have anti-infectious traditional uses. However, reports about their potential use against neglected tropical ailments, such as Chagas disease, are scarce.
Catarina G. Pereira +9 more
doaj +1 more source
Toxicon, 2023 African trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually.
Ameh Ilu +7 more
semanticscholar +1 more source
Fundamental & Clinical Pharmacology, 2023 Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa.
Anna Seetsi +5 more
semanticscholar +1 more source
Sahel Journal of Veterinary Sciences, 2023 Allium sativum Linn. is a bulbos perennial plant of the Family Liliaceae has been reported as having potential medicinal properties. This study was on the phytochemistry, in vitro anti-trypanosomal efficacy and acute toxicity of Allium sativum Linn bulb ...
A. Biu +5 more
semanticscholar +1 more source
TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome. [PDF]
FEBS JProtein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
von Känel C +8 more
europepmc +2 more sources