Results 41 to 50 of about 1,940,104 (187)

Cinnamoylphenethyl Amides from Possess Anti-Trypanosomal Activity

Natural Product Communications, 2012
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC 50 =3.7 μg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides,
Fahimeh Moradi-Afrapoli, Nargues Yassa, Stefanie Zimmermann, Soodabeh Saeidnia, Abbas Hadjiakhoondi, Samad N. Ebrahimi, Matthias Hamburger   +6 more
doaj   +1 more source

In-silico analysis of bufadienolides as potential inhibitors of Trypanosoma nucleoside hydrolase

Chemical Physics Impact, 2023
Trypanosomiasis is one of the neglected tropical diseases which curtails the productivity of the victim and causes mortality in extreme cases. Non-availability of vaccines, low therapeutic index of trypanocidal drugs and development of resistance lead to
Shalaka R. Sawant, Shreyas S. Dindorkar, Harshali S. Patkar, Palavee P. Nyayadhish, Akshay D. Bagwe, Anshul Yadav, Bharatbhushan B. Sharma   +6 more
doaj   +1 more source

Anti-trypanosomal activity of cysteine protease inhibitors.

, 2017
Anti-trypanosomal activity of cysteine protease inhibitors.
Andrei Leitão (769676), Sérgio de Albuquerque (769673), Juliana C. Gomes (1883650), Carlos A. Montanari (449507), Jean F. R. Ribeiro (769678), Mark Furber (2465680), Cristiana Gonçalez (769674), Peter W. Kenny (769675), Antonio C. B. Burtoloso (1776874), José Carlos Quilles Júnior (3769651), Josmar R. Rocha (449500)   +10 more
core   +1 more source

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a–7e, 8a–8e, and 9a–9e were designed and synthesised with the aim of evaluating their anti-bacterial and anti-trypanosomal activities and ...
Andrea Bistrović, Luka Krstulović, Ivana Stolić, Domagoj Drenjančević, Jasminka Talapko, Martin C. Taylor, John M. Kelly, Miroslav Bajić, Silvana Raić-Malić   +8 more
doaj   +1 more source

Anti-trypanosomal Potential of Eucalyptus Camaldulensis

British Journal of Pharmacology and Toxicology, 2013
Chemotherapy of African trypanosomiasis in both the human and animal forms has been confronted with multidimensional problems that include paucity of drugs, resistance, high cost, prolonged treatment protocol and adverse side effects. The main objective of this study was to explore alternative sources of antitrypanosomal agents from the leaves, stem ...
Y.A. Kabiru, E.O. Ogbadoyi, J.I. Okogun, T.A. Gbodi, H.A. Makun   +4 more
openaire   +1 more source

Mechanism of Action and Implication of Naphthoquinone as Potent Anti-trypanosomal Drugs

Current Topics in Medicinal Chemistry, 2022
Abstract:Naphthoquinone is a heterocyclic moiety whose natural derivatives are present as bioac-tive compounds in many plants and have stimulated a resurgence of interest in the past decades due to their wide range of pharmacological activities. Naphthoquinone agents have dynamic pharmaco-phores and privileged sub-structures in the chemistry of ...
Ruma Rani, Khushboo Sethi, Snehil Gupta, Rajender S. Varma, Rajender Kumar   +4 more
openaire   +3 more sources

Anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal plants [PDF]

, 2011
This chapter explores the anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal ...
Gray, Alexander, Clements, Carol, Igoli, John, Mouad, Hazar   +3 more
core   +4 more sources

Anti-trypanosomal activity of compounds on Trypanosoma brucei brucei.

, 2019
Anti-trypanosomal activity of compounds on Trypanosoma brucei brucei.
Jonathan Partt Adjimani (6397199), Cynthia Mmalebna Amisigo (6397196), Christine Achiaa Antwi (6397193), Theresa Manful Gwira (4459087)   +3 more
core   +1 more source

Reported anti-trypanosomal endoperoxides.

, 2012
Reported anti-trypanosomal endoperoxides.
Supchar Chokpaiboon (132469), James H. McKerrow (113918), Geraldine De Muylder (132472), Sean C. Nisam (132477), Roger G. Linington (132483), Khanitha Pudhom (132480), Gabriel Navarro (132468), Walter M. Bray (132474)   +7 more
core   +1 more source

In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense

UMYU Journal of Microbiology Research
The development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M., Inabo, H. I., Ella, E. E., Okubanjo, O. O.   +3 more
doaj   +1 more source