Results 41 to 50 of about 3,061,970 (186)

In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones [PDF]

Drug Research, 2018
Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting.
Beteck, Richard M, Legoabe, Lesetje J, Isaacs, Michelle, Hoppe, Heinrich C   +3 more
openaire   +4 more sources

Beta-carboline as a promising heterocyclic nucleus: Synthetic aspects, pharmacological potential and structure activity relationship

European Journal of Medicinal Chemistry Reports, 2022
Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic nucleus in the field of medicinal chemistry. It has different biological activities like antibacterial, anticancer, antifungal, antimalarial, antileishmanial, anti ...
Mahender Thatikayala, Pankaj Wadhwa, Paranjeet Kaur, Pankaj Kumar Singh, Ankit Yadav, Monika Kaushik, Sanjeev Kumar Sahu   +6 more
doaj   +1 more source

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats [PDF]

Asian Pacific Journal of Tropical Biomedicine, 2013
Abimbola AM, Baba IA, Yenusa EZ, Omanibe SJ, Oladimeji IH.   +4 more
exaly   +2 more sources

Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. [PDF]

PLoS Neglected Tropical Diseases, 2011
Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), expresses two proteins with homology to human glycogen synthase kinase 3β (HsGSK-3) designated TbruGSK-3 short and TbruGSK-3 long.
Richard O Oduor, Kayode K Ojo, Gareth P Williams, Francois Bertelli, James Mills, Louis Maes, David C Pryde, Tanya Parkinson, Wesley C Van Voorhis, Tod P Holler   +9 more
doaj   +1 more source

Molecular identification of Trypanosoma brucei brucei and in vitro anti-trypanosomal activity of different parts of methanolic extract of Senna occidentalis

Clinical Phytoscience, 2020
Objective The present study investigated the anti-Trypanosoma brucei brucei activity of methanolic extract of Senna occidentalis roots, leaves, stem bark, and seed in vitro and bioactive components of the most active plant part.
Zainab Aliyu Alhafiz, Mohammed Sani Abdulsalami, Mohammed Auwal Ibrahim, Timothy Bulus, Ahmed Babangida Suleiman   +4 more
doaj   +1 more source

Chemical characterization of Saudi propolis and its antiparasitic and anticancer properties

Scientific Reports, 2021
Propolis, is a gummy material produced by honey bees from different parts of plants and is enriched with varied biological active compounds like flavonoids, phenolics and phenolic acids with wide applicability in the food, pharmaceutical and cosmetics ...
Samyah Alanazi, Naif Alenzi, Fouza Alenazi, Hajera Tabassum, David Watson   +4 more
doaj   +1 more source

Anti-Trypanosomal Alkaloids from

Natural Product Communications, 2006
From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid ( 1 ), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N ...
Dieudonne Ngamga, Pierre Tane, Donna Rattendi, Cyrus Bacchi, Christopher C. Okunji, Maurice M. Iwu, Brian M. Schuster, Olov Sterner   +7 more
doaj   +1 more source

EUCALYPTUS OIL NANOEMULSION: EVALUATION OF IN VITRO ACTIVITY AGAINST TRYPANOSOMA BRUCEI [PDF]

Zagazig Journal of Pharmaceutical Sciences
Background: Natural products and their secondary metabolites are a good source of pharmacologically active constituents and have been widely developed into modern medicines.
Emmanuel Maduabuchi Uronnachi, Patience Sunday Ngbo, Somtochukwu Richard Ewuzie, Chidalu Benedicta Ikeotuonye, Anthony Amaechi Attama   +4 more
doaj   +1 more source

Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections

Molecules, 2020
Neglected parasitic diseases remain a major public health issue worldwide, especially in tropical and subtropical areas. Human parasite diversity is very large, ranging from protozoa to worms.
Liwen Feng, Sébastien Pomel, Perle Latre de Late, Alexandre Taravaud, Philippe M. Loiseau, Louis Maes, Fidelis Cho-Ngwa, Christina A. Bulman, Chelsea Fischer, Judy A. Sakanari, Peter D. Ziniel, David L. Williams, Elisabeth Davioud-Charvet   +12 more
doaj   +1 more source

Toxicity study and anti-trypanosomal activities of aqueous and methanol whole plant extracts of Brillantaisia owariensis on Trypanosoma brucei-induced infection in BALB/c mice

Clinical Phytoscience, 2021
Background The problem of drug resistance and toxicity in trypanosomiasis is ever-increasing, thereby creating a need to search for efficacious and safer alternatives that are of plant origin.
Nafisa Garba Ayawa, S. Ramon-Yusuf, Y. Wada, S. Oniye, D. M. Shehu   +4 more
semanticscholar   +1 more source