Results 41 to 50 of about 3,031 (126)

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Nicoli Dias Oliveira, Mariana Cintra Pagotti, Lucas Antonio de Lima Paula, Mariana Zaramello Paixão, Daiane Albino dos Santos, Renata Faleiros de Freitas, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães   +9 more
wiley   +1 more source

CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei.
Georges C. Accrombessi, Jacques Poupaert, Raymond H. Fatondji, Salomé D. S. Kpoviessi, Fernand A. Gbaguidi, Bienvenu Glinma   +5 more
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Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source

Chemical Composition, Antioxidant, and Antibacterial Activities of Mezilaurus duckei (Lauraceae)

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Mezilaurus duckei, a Brazilian endemic tree species found exclusively in the Amazon Rainforest, is primarily exploited for timber in construction. Due to its endangered status, this study aimed to investigate the chemical profile and biological properties of the ethanolic extract and its phases derived from M. duckei leaves. Chemical profiling
Bruna S. Moroto, Valéria S. Gonçalves, David J. Machate, Talita V. Freire, Érica L. Santos, Flávio M. Alves, Ana C. Micheletti, Nídia C. Yoshida   +7 more
wiley   +1 more source

Dereplication Strategies for Targeted Isolation of New Antitrypanosomal Actinosporins A and B from a Marine Sponge Associated-Actinokineospora sp. EG49

Marine Drugs, 2014
High resolution Fourier transform mass spectrometry (HRFTMS) and nuclear magnetic resonance (NMR) spectroscopy were employed as complementary metabolomic tools to dereplicate the chemical profile of the new and antitrypanosomally active sponge ...
Usama Ramadan Abdelmohsen, Cheng Cheng, Christina Viegelmann, Tong Zhang, Tanja Grkovic, Safwat Ahmed, Ronald J. Quinn, Ute Hentschel, RuAngelie Edrada-Ebel   +8 more
doaj   +1 more source

Bioactivity Profiles of Progressively Ring‐Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto‐Piperazines as Antitrypanosome Agents

ChemBioChem, Volume 26, Issue 22, November 17, 2025.
All‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
Mengfan He, Christina M. Thomson, Dawn Thompson, Vytautus Kuodis, Terry K. Smith, Sergio Dall’Angelo, David O’Hagan   +6 more
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Potential Therapeutic Actions of Flavonoids Present in Propolis That Modulate Vascular Endothelial Growth Factor Signaling to Regulate Angiogenesis

Phytotherapy Research, Volume 39, Issue 9, Page 4230-4246, September 2025.
ABSTRACT Propolis is a plant‐derived substance collected by honeybees that has a range of potential therapeutic applications. Propolis consists of resins, waxes, and fatty acids, as well as essential oils and other organic compounds. The pharmacologically active components of propolis include phenols and flavonoids, among others.
Yipeng Lin, Janney Z. Wang, Yihe Niu, Ling Zhu, Rujee K. Duke, Colin C. Duke, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

Epidemiological studies (parasitological, serological and molecular techniques) of Trypanosoma evansi infection in camels (Camelus dromedarius) in Egypt [PDF]

Veterinary World, 2008
Trypanosomosis in camel caused by Trypanosoma evansi is still a serious problem in camel husbandry causes considerable economic losses in many camel-rearing regions of the world.
Ahmed Abdel-Rady
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