Results 61 to 70 of about 3,031 (126)

Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

European Journal of Heart Failure, Volume 26, Issue 12, Page 2502-2514, December 2024.
Main pathophysiological components influencing mortality in chronic Chagas cardiomyopathy. LV, left ventricular; PVC, premature ventricular contraction; VT, ventricular tachycardia. Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi.
Luis E. Echeverría, Angie Yarlady Serrano‐García, Lyda Z. Rojas, Enrique A. Berrios‐Bárcenas, Juan Esteban Gómez‐Mesa, Sergio A. Gómez‐Ochoa   +5 more
wiley   +1 more source

Anti-trypanosomal Potential of Methanolic Extract of Calotropis gigantea Leaves against Trypanosma evansi and its Cytotoxicity

International Journal of Bio-Resource and Stress Management, 2023
In an attempt to find anti-trypanosomal extract/compound(s) from medicinal plant for the treatment of trypanosomosis, Calotropis gigantea leaves were extracted with methanol. The obtained extract was screened at concentrations (250-1000 μg ml-1) against 
P. Shaba, N. N. Pandey, O. P. Sharma, J. R. Rao, R. K. Singh   +4 more
doaj  

Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae) Atividade anti-tripanosomicida de triterpenes pentacíclicos isolados de Austroplenckia populnea (Celastraceae)

Revista do Instituto de Medicina Tropical de São Paulo, 2002
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less ...
Lucienir Pains DUARTE, Sidney Augusto VIEIRA FILHO, Grácia Divina de Fátima SILVA, José Rego de SOUSA, Artur da Silveira PINTO   +4 more
doaj   +1 more source

ANTI-TRYPANOSOMAL EFFECTS O7F SOME SELECTED NIGERIAN MEDICINAL PLANTS

Academy Journal of Science and Engineering
Treatments of African trypanosomiasis have been dependent on the use of synthetic drugs which have several drawbacks. This is compounded by the emergence of drug-resistant parasites.
Enimie Endurance Oaikhena, Yahaya Umar, Vantsawa Philip, Ibeh Onyinye   +3 more
doaj   +1 more source

Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent

Frontiers in Pharmacology, 2016
The different pharmacologic properties of plants-containing cynaropicrin, especially artichokes, have been known for many centuries. More recently, cynaropicrin exhibited a potential activity against all genotypes of hepatitis C virus (HCV). Cynaropicrin
Mahmoud Fahmi Elsebai, Andrei Mocan, Atanas G. Atanasov, Atanas G. Atanasov   +3 more
doaj   +1 more source

Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad Rhinella alata (Anura, Bufonidae). [PDF]

Molecules, 2023
Rodriguez C, Ibáñez R, Olmedo DA, Ng M, Spadafora C, Durant-Archibold AA, Gutiérrez M.   +6 more
europepmc   +1 more source

Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity

Heliyon, 2019
Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide.
Nahir Dib, Luciana Fernández, Marisa Santo, Luis Otero, Fabrisio Alustiza, Ana Cecilia Liaudat, Pablo Bosch, M. Laura Lavaggi, Hugo Cerecetto, Mercedes González   +9 more
doaj   +1 more source

2α-Acetoxy-15-acetylartemisiifolin, a new Anti-trypanosomal Sesquiterpene Lactone from

Natural Product Communications, 2017
Mikania guaco Bonpl. methanol extract showed an interesting activity against Trypanosoma cruzi with an IC 50 of 4 μg/mL. Bioassay-guided fractionation of the methanol extract resulted in the isolation of a new sesquiterpene lactone, 2α-acetoxy, 15 ...
Ahmed A. Hussein, Luz Romero, Jose Luis López-Pérez, Mahabir P. Gupta   +3 more
doaj   +1 more source

Anti-trypanosomal screening of Salvadoran flora. [PDF]

J Nat Med, 2022
Castillo UG, Komatsu A, Martínez ML, Menjívar J, Núñez MJ, Uekusa Y, Narukawa Y, Kiuchi F, Nakajima-Shimada J.   +8 more
europepmc   +1 more source

Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives

Biomolecules, 2016
There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu, Guanzhong Mao, Leif A. Kirsebom   +2 more
doaj   +1 more source