Results 61 to 70 of about 3,061,970 (186)

Anti-trypanosomal activity of crude and nano-conjugated ethanol stem bark extracts of Sterculia setigera in mice

Bayero Journal of Pure and Applied Sciences, 2021
This study was carried out to screen for anti-trypanosomal activities of Sterculia setigera crude and nano-conjugated ethanol extracts of synthesized gold nanoparticles (AuNPs). Fresh stem bark of S.
M. Abdulrazaq, H. Adeyemi, A. Abdulkareem, M. T. Bankole, A. Abubakar   +4 more
semanticscholar   +1 more source

Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials.

The Lancet Microbe
BACKGROUND Determining parasitological cure in chronic Chagas disease is compromised by very low blood trypomastigote densities, which fluctuate close to or below the limit of quantitative PCR (qPCR) detection (approximately one parasite per 10 mL).
J. A. Watson, C. Cruz, F. Barreira, C. Forsyth, A. Schijman, R. Peploe, F. Assmus, C. Naylor, Jennifer H Lee, S. Mehra, J. Tarning, F. Torrico, J. Gascón, L. Ortiz, I. Ribeiro, S. Sosa-Estani, Craig Tipple, S. Hugonnet, Philippe J. Guerin, L. Fraisse, M. Pinazo, N. J. White   +21 more
semanticscholar   +1 more source

In Vitro Anti-Trypanosomal Activity of Aqueous Extracts of Viscum album (Mistletoe) Leaf and Stem from Three Host Plants

Arid-zone Journal of Basic & Applied Research, 2022
In sub-Saharan Africa, trypanosomosis is a constraint on livestock production. Thus, it is imperative to develop alternative strategies since current chemotherapy is bedevilled by high cost and limited access.
W. John, Lawan B. Buratai, Abdullahi A. Biu, J. Luka, ThankGod E. Onyiche   +4 more
semanticscholar   +1 more source

In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense

UMYU Journal of Microbiology Research
The development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M., Inabo, H. I., Ella, E. E., Okubanjo, O. O.   +3 more
doaj   +1 more source

CL 64, 855, a potent do anti-Trypanosoma cruzi drug, is also mutagenic in the salmonella/microsome assay

Memorias do Instituto Oswaldo Cruz, 1986
The nitroimidazole-tiadiazole derivative CL 64,855 (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole, a potent anti-trypanosomal drug, was assayed in a short-term bacterial mutagenicity test with Salmonella typhimurium strains TA 98, TA 100 ...
R. C. C. Ferreira, L. C. S. Ferreira
doaj   +1 more source

Generation of Monoclonal Antibodies to the Anti-Trypanosomal Drug Isometamidium

Hybridoma, 1994
Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognized conjugated and unconjugated isometamidium, but lacked ...
Peregrine, A.S., Eisler, M.C., Katende, J., Flynn, J.N., Gault, E.A., Kinabo, L.D.B., Holmes, P.H.   +6 more
openaire   +2 more sources

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source

Eugenia uniflora and Syzygium samarangense extracts exhibit anti-trypanosomal activity: Evidence from in-silico molecular modelling, in vitro, and in vivo studies.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
The parasite Trypanosoma brucei is the main cause of the sleeping sickness threatening millions of populations in many African countries. The parasitic infection is currently managed by some synthetic medications, most of them suffer limited activity ...
Mohamed A. O. Abdelfattah, M. Ibrahim, H. Abdullahi, Raphael Aminu, S. Saad, S. Krstin, M. Wink, Mansour Sobeh   +7 more
semanticscholar   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense

Molecules, 2017
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, “sleeping sickness”), we have investigated extracts from the leaves and bark of the West African Holarrhena ...
Charles Okeke Nnadi, Ngozi Justina Nwodo, Marcel Kaiser, Reto Brun, Thomas J. Schmidt   +4 more
doaj   +1 more source