Results 51 to 60 of about 3,031 (126)

Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)

Química Nova, 2012
MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D ...
Roberta T. dos Santos, Liliane L. Hiramoto, João Henrique G. Lago, Patrícia Sartorelli, André G. Tempone, Erika G. Pinto   +5 more
doaj   +1 more source

The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review

Health Science Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background and Aims Rwanda is among the African countries affected by neglected tropical diseases (NTDs). This scoping review aims to synthesize available information to understand the prevalence, incidence, distribution, morbidity, mortality, and risk factors of NTDs in Rwanda.
Masceline Jenipher Mutsaka‐Makuvaza, Michael Olubusayo Binuyo, Callixte Cyuzuzo, Acsa Igizeneza, Jean Paul Sinumvayo, Oluwaremilekun Grace Ajakaye, Egie Elisha Enabulele, Zororo Chinwadzimba, Ezera Agwu, Nicholas Midzi   +9 more
wiley   +1 more source

Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides

Communications Chemistry
Sets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity.
Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright   +6 more
doaj   +1 more source

Overproduction and Characterization of Recombinant Soluble Trypanosoma brucei Phospholipase A2

Engineering in Life Sciences, Volume 25, Issue 3, March 2025.
ABSTRACT Trypanosoma brucei phospholipase A2 (TbPLA2) is a validated drug target but the difficulty in expressing its soluble recombinant protein has limited its exploitation for drug and vaccine development for African and American trypanosomiases. We utilized recombinant deoxyribonucleic acid (DNA) technology approaches to express soluble TbPLA2 in ...
Oluwafemi Abiodun Adepoju, Daniel Quinnell, Harshverdhan Sirohi, Emmanuel Amlabu, Abdullahi Balarabe Sallau, Abdulrazak Ibrahim, Sunday Ene‐Ojo Atawodi, Mohammed Nasiru Shuaibu, Geoffrey Chang, Emmanuel Oluwadare Balogun   +9 more
wiley   +1 more source

The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical ...
Gioele Renzi, Federico Ladu, Fabrizio Carta, Claudiu T. Supuran   +3 more
wiley   +1 more source

Comparative Analysis of the Interaction of Silver Nanoparticles with Hexokinase from Trypanosoma brucei and Humans

International Journal of Nanomedicine, 2023
Madalitso M Mlozen,1,2 Jacqueline Van Marwijk,1 Brendan Shane Wilhelmi,1 Chris Whiteley1 1Department of Biochemistry and Microbiology, Rhodes University, Makhanda (Grahamstown), South Africa; 2Malawi Adventist University, Malamulo Campus, Department of ...
Mlozen MM, Van Marwijk J, Wilhelmi BS, Whiteley C   +3 more
doaj  

In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Química Nova, 2012
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized.
Patricia Sartorelli, Jefferson S. Santana, Rafael C. Guadagnin, João Henrique G. Lago, Érika G. Pinto, André G. Tempone, Hélio A. Stefani, Marisi G. Soares, Adalberto M. da Silva   +8 more
doaj   +1 more source

Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Battling female infertility has posed a global challenge, where neglected tropical diseases (NTDs) are nonetheless a notable contributing factor. NTDs affect a variety of diseases, often of a chronic nature, which are often cited as some of the most lethal diseases operating against the most economically disadvantaged populations across the globe.
Moses Agbomhere Hamed, Olabanji Ahmed Surakat, Victor Olukayode Ekundina, Kabirat Bolajoko Jimoh, Adetomiwa Ezekiel Adeogun, Nafisat Omolola Akanji, Oluwafemi Joshua Babalola, Patrick Chukwunonso Eya, Rajib Chowdhury   +8 more
wiley   +1 more source

The development of an enzyme-linked immunosorbent assay for Trypanosoma vivax antibodies and its use in epidemiological surveys

Memorias do Instituto Oswaldo Cruz, 2006
There are data indicating that the distribution of Trypanosoma vivax in the Brazilian territory is expanding with potential to reach other areas, where the vectors are present.
Claudio R Madruga, Flábio R Araújo, Gustavo Cavalcante-Goes, Charles Martins, Ingá B Pfeifer, Laura R Ribeiro, Raul H Kessler, Cleber O Soares, Midori Miguita, Elaine PS Melo, Robson FC Almeida, Manoel MSC Lima Jr.   +11 more
doaj   +1 more source

ESI MS Studies of T. Brucei Trypanothione Reductase and its Reactions With Selected Metal Compounds

European Journal of Inorganic Chemistry, Volume 27, Issue 36, December 20, 2024.
The study investigates the interactions between Trypanothione reductase from Trypanosoma brucei (TbTR) and selected metal compounds using ESI‐MS measurements. The findings describe how these compounds bind to TbTR, highlighting their potential as novel anti‐parasitic agents by targeting this crucial enzyme, which is essential for the parasite's ...
Stefano Zineddu, Andrea Geri, Andrea Ilari, Gianni Colotti, Cécile Exertier, Annarita Fiorillo, Lorenzo Antonelli, Luigi Messori   +7 more
wiley   +1 more source