Results 51 to 60 of about 3,061,970 (186)

Anti-trypanosomal Activity of Bufonidae (Toad) Venom Crude Extract on Trypanosoma brucei brucei in Swiss Mice

Journal of Zoological Research, 2022
Trypanosomiasis afflicts about 6 ~ 7 million people globally and to a large extent impedes livestock production in Africa. Naturally, trypanosomal parasites undergo genetic mutation and have developed resistance over a wide range of therapies.
E. J., P. A., Uzoigwe N. R., Omalu I. C. J., O. A, A. O., Ameh S. F., T. S., Adejoh V. A., A. S., Ayim J. O., Daramola O. S., Aimankhu P. O., Maikenti J. I., A. J., A. O., A. A, A. A., O. A., A. E., Kure M. S.   +20 more
semanticscholar   +1 more source

Hinokinin, an Emerging Bioactive Lignan

Molecules, 2014
Hinokinin is a lignan isolated from several plant species that has been recently investigated in order to establish its biological activities. So far, its cytotoxicity, its anti-inflammatory and antimicrobial activities have been studied.
Maria Carla Marcotullio, Azzurra Pelosi, Massimo Curini   +2 more
doaj   +1 more source

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. [PDF]

PLoS Neglected Tropical Diseases, 2018
Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the
Eva Doleželová, David Terán, Ondřej Gahura, Zuzana Kotrbová, Michaela Procházková, Dianne Keough, Petr Špaček, Dana Hocková, Luke Guddat, Alena Zíková   +9 more
doaj   +1 more source

Cinnamoylphenethyl Amides from Possess Anti-Trypanosomal Activity

Natural Product Communications, 2012
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC 50 =3.7 μg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides,
Fahimeh Moradi-Afrapoli, Nargues Yassa, Stefanie Zimmermann, Soodabeh Saeidnia, Abbas Hadjiakhoondi, Samad N. Ebrahimi, Matthias Hamburger   +6 more
doaj   +1 more source

In-silico analysis of bufadienolides as potential inhibitors of Trypanosoma nucleoside hydrolase

Chemical Physics Impact, 2023
Trypanosomiasis is one of the neglected tropical diseases which curtails the productivity of the victim and causes mortality in extreme cases. Non-availability of vaccines, low therapeutic index of trypanocidal drugs and development of resistance lead to
Shalaka R. Sawant, Shreyas S. Dindorkar, Harshali S. Patkar, Palavee P. Nyayadhish, Akshay D. Bagwe, Anshul Yadav, Bharatbhushan B. Sharma   +6 more
doaj   +1 more source

Synthesis, molecular docking analysis and in-vitro evaluation of 1,4-dihydroxyanthraquinone derivatives as anti-trypanosomal agents

Letters in Organic Chemistry, 2022
Hydroxy-substituted anthraquinones are among the most important derivatives in organic synthesis. The attractive biological properties of these compounds are relevant to many therapeutic areas that are of use in clinical applications.
Lydia Kisula, X. Siwe-Noundou, Tarryn Swart, H. Hoppe, Q. Mgani, R. Krause   +5 more
semanticscholar   +1 more source

Synthesis and in vitro anti-trypanosomal evaluation of quinolone hydrazide analogues

Medicinal Chemistry Research
African trypanosomiasis is a major health threat to humans and animals in 36 countries within sub-Saharan Africa. We previously identified quinolone hydrazides exhibiting sub-micromolar anti-trypanosomal activity.
Phelelisiwe S. Dube, Sarah Makgoba, Karol R. Francisco, L. Legoabe, Conor R. Caffrey, Richard M. Beteck   +5 more
semanticscholar   +1 more source

Proximate Composition of Wild Honey Harvested from Shani Local Government Area (LGA) of Borno State, Nigeria and its Anti-Trypanosomal Efficacy on Trypanosoma Brucei Brucei Infected Wistar Rats

Journal of Applied Sciences and Environmental Management
Honey is a food substance produced by honeybees Apis mellifera adansonii with its quality based on its origin and is widely acknowledged for its nutritional and medicinal uses. The objective of this paper was to evaluate the proximate composition of wild
J. Wasagwa, A. Zainab, A. Haruna, A. A. Biu, L. Buratai, L. J. Wabba   +5 more
semanticscholar   +1 more source

Anti-trypanosomal Potential of Eucalyptus Camaldulensis

British Journal of Pharmacology and Toxicology, 2013
Chemotherapy of African trypanosomiasis in both the human and animal forms has been confronted with multidimensional problems that include paucity of drugs, resistance, high cost, prolonged treatment protocol and adverse side effects. The main objective of this study was to explore alternative sources of antitrypanosomal agents from the leaves, stem ...
Y.A. Kabiru, E.O. Ogbadoyi, J.I. Okogun, T.A. Gbodi, H.A. Makun   +4 more
openaire   +1 more source

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a–7e, 8a–8e, and 9a–9e were designed and synthesised with the aim of evaluating their anti-bacterial and anti-trypanosomal activities and ...
Andrea Bistrović, Luka Krstulović, Ivana Stolić, Domagoj Drenjančević, Jasminka Talapko, Martin C. Taylor, John M. Kelly, Miroslav Bajić, Silvana Raić-Malić   +8 more
doaj   +1 more source