Results 41 to 50 of about 2,622 (160)

Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi

Molbank, 2022
In this work, we present the synthesis and the anti-trypanosomal activity of the 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b and the 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c.
Angeliki Sofia Foscolos, Andrew Tsotinis, Martin C. Taylor, John M. Kelly, Ioannis P. Papanastasiou   +4 more
doaj   +1 more source

Hinokinin, an Emerging Bioactive Lignan

Molecules, 2014
Hinokinin is a lignan isolated from several plant species that has been recently investigated in order to establish its biological activities. So far, its cytotoxicity, its anti-inflammatory and antimicrobial activities have been studied.
Maria Carla Marcotullio, Azzurra Pelosi, Massimo Curini   +2 more
doaj   +1 more source

Beta-carboline as a promising heterocyclic nucleus: Synthetic aspects, pharmacological potential and structure activity relationship

European Journal of Medicinal Chemistry Reports, 2022
Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic nucleus in the field of medicinal chemistry. It has different biological activities like antibacterial, anticancer, antifungal, antimalarial, antileishmanial, anti ...
Mahender Thatikayala, Pankaj Wadhwa, Paranjeet Kaur, Pankaj Kumar Singh, Ankit Yadav, Monika Kaushik, Sanjeev Kumar Sahu   +6 more
doaj   +1 more source

Anti-trypanosomal activity of secnidazole in vitro and in vivo

Tropical Journal of Pharmaceutical Research, 2017
Purpose: To evaluate the anti-trypanosomal effect of secnidazole (SEC) in vitro and in vivo. Methods: The dose-response effect of SEC in Trypanosoma b. brucei infected rats was evaluated in five groups of rats (n = 5). Group A was infected but untreated; B was given diminazene aceturate (DA) (3.5 mg/kg) intraperitoneally, while groups C, D and E ...
Eke, Ifeanyi G, Eze, Ikenna O, Ezeudu, Terry A, Eze, Ukamaka U, Anaga, Aruh O, Onyeyili, Patrick A   +5 more
openaire   +3 more sources

Orally Active and Selective Tubulin Inhibitors as Anti-Trypanosome Agents

PLOS ONE, 2016
There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates for the treatment of this disease, which is based on the tubulin protein structural difference between mammalian ...
Vishal Nanavaty, Rati Lama, Ranjodh Sandhu, Bo Zhong, Daniel Kulman, Viharika Bobba, Anran Zhao, Bibo Li, Bin Su   +8 more
openaire   +4 more sources

Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity [PDF]

Bioorganic & Medicinal Chemistry Letters, 2009
A series of alkanediamide-linked bisbenzamidines was synthesized and tested in vitro against a drug-sensitive strain of Trypanosoma brucei brucei, a drug-resistant strain of Trypanosoma brucei rhodesiense and Pneumocystiscarinii. Bisbenzamidines linked with longer alkanediamide chains were potent inhibitors of both strains of T. brucei.
Huang, T.L., Vanden Eynde, Jean-Jacques, Mayence, A., Collins, M.S., Cushion, M.T., Rattendi, D., Londono, I., Mazumder, L., Bacchi, C.J., Yartlet, N.   +9 more
openaire   +3 more sources

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. [PDF]

PLoS Neglected Tropical Diseases, 2018
Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the
Eva Doleželová, David Terán, Ondřej Gahura, Zuzana Kotrbová, Michaela Procházková, Dianne Keough, Petr Špaček, Dana Hocková, Luke Guddat, Alena Zíková   +9 more
doaj   +1 more source

Anti-trypanosomal Phenolic Derivatives from

Natural Product Communications, 2014
Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a ...
Simone dos S. Grecco, Maria Júlia P. Félix, João Henrique G. Lago, Érika G. Pinto, André G. Tempone, Paulete Romoff, Marcelo José P. Ferreira, Patricia Sartorelli   +7 more
doaj   +1 more source

In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense

UMYU Journal of Microbiology Research
The development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M., Inabo, H. I., Ella, E. E., Okubanjo, O. O.   +3 more
doaj   +1 more source

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a–7e, 8a–8e, and 9a–9e were designed and synthesised with the aim of evaluating their anti-bacterial and anti-trypanosomal activities and ...
Andrea Bistrović, Luka Krstulović, Ivana Stolić, Domagoj Drenjančević, Jasminka Talapko, Martin C. Taylor, John M. Kelly, Miroslav Bajić, Silvana Raić-Malić   +8 more
doaj   +1 more source