Results 41 to 50 of about 251,222 (192)

Anti-trypanosomal activity of compounds on Trypanosoma brucei brucei. [PDF]

, 2019
Anti-trypanosomal activity of compounds on Trypanosoma brucei brucei.
Jonathan Partt Adjimani (6397199), Cynthia Mmalebna Amisigo (6397196), Christine Achiaa Antwi (6397193), Theresa Manful Gwira (4459087)   +3 more
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Organocatalytic synthesis and Anti-Trypanosomal activity evaluation of L-Pentofuranose-Mimetic iminosugars [PDF]

, 2022
Versión aceptada (Postprint)A series of L-lyxo and L-xylo- pentofuranose-mimetic iminosugars and derivatives were efficiently synthesized in a stereoselective manner, through a concise strategy which involves an organocatalyzed Mannich reaction of an ...

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Establishment of a structure-activity relationship of the 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness [PDF]

, 2014
The compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against T. brucei cultures. With an eye towards using 1 as a starting point for
Pollastri, Michael P, Smith, Terry K, Berlanga, Manuela, Luengo-Arratta, Sandra A, Rojas-Barros, Domingo I, Saldivia, Manuel, Diaz, Rosario, Gonzalez, Silvia, Seixas, João D, Manzano, Pilar, Navarro, Miguel   +10 more
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Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

PLoS Neglected Tropical Diseases, 2012
The image for Figure 1 is incorrect.
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier   +6 more
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Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi

Molbank, 2022
In this work, we present the synthesis and the anti-trypanosomal activity of the 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b and the 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c.
Angeliki Sofia Foscolos, Andrew Tsotinis, Martin C. Taylor, John M. Kelly, Ioannis P. Papanastasiou   +4 more
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Hinokinin, an Emerging Bioactive Lignan

Molecules, 2014
Hinokinin is a lignan isolated from several plant species that has been recently investigated in order to establish its biological activities. So far, its cytotoxicity, its anti-inflammatory and antimicrobial activities have been studied.
Maria Carla Marcotullio, Azzurra Pelosi, Massimo Curini   +2 more
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Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants [PDF]

, 2009
The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua (Asteraceae), Pseudospondias microcarpa (Anacardiaceae ...
Brun, R., Swaleh, SAM, R Brun, Malebo, H.M., Ndiege, I. O., W Tanja, I.O Ndiege, Swaleh, S. A., Hassanali, A., Wenzler, T., Hassanali, A, Hamburger, M., M Cal, Ndiege, I.O, A Hassanali, U Séquin, Hamburger, M, Omolo, M. O., SAM Swaleh, Séquin, U, Malebo, H.M, Tanja, W., M Hamburger, Swaleh, S.A.M., Séquin, U., Cal, M., Omolo, M.O, Brun, R, Ndiege, I.O., Malebo, H. M., Cal, M, H.M Malebo, Omolo, M.O., M.O Omolo, Tanja, W, Swaleh, S. A. M.   +35 more
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Beta-carboline as a promising heterocyclic nucleus: Synthetic aspects, pharmacological potential and structure activity relationship

European Journal of Medicinal Chemistry Reports, 2022
Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic nucleus in the field of medicinal chemistry. It has different biological activities like antibacterial, anticancer, antifungal, antimalarial, antileishmanial, anti ...
Mahender Thatikayala, Pankaj Wadhwa, Paranjeet Kaur, Pankaj Kumar Singh, Ankit Yadav, Monika Kaushik, Sanjeev Kumar Sahu   +6 more
doaj   +1 more source

Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity [PDF]

Bioorganic & Medicinal Chemistry Letters, 2009
A series of alkanediamide-linked bisbenzamidines was synthesized and tested in vitro against a drug-sensitive strain of Trypanosoma brucei brucei, a drug-resistant strain of Trypanosoma brucei rhodesiense and Pneumocystiscarinii. Bisbenzamidines linked with longer alkanediamide chains were potent inhibitors of both strains of T. brucei.
Huang, T.L., Vanden Eynde, Jean-Jacques, Mayence, A., Collins, M.S., Cushion, M.T., Rattendi, D., Londono, I., Mazumder, L., Bacchi, C.J., Yartlet, N.   +9 more
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Anti-trypanosomal Activity of Bufonidae (Toad) Venom Crude Extract on Trypanosoma brucei brucei in Swiss Mice [PDF]

, 2022
Trypanosomiasis afflicts about 6 ~ 7 million people globally and to a large extent impedes livestock production in Africa. Naturally, trypanosomal parasites undergo genetic mutation and have developed resistance over a wide range of therapies.
S., Attah A., O., Ayim J., S., Tanko N., A., Pam V., S., Kure M., O., Aimankhu P., F., Ameh S., S., Daramola O., A., Ashigar M., A., Aliyu A., J., Omalu I. C., J., Ajah L., J., Ezeobi A., A., Adejoh V., A., Odey S., E., Anyebe G., I., Maikenti J., R., Uzoigwe N., O., Ayuba S., A., Ombugadu, O., Ahmed H.   +20 more
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