Results 41 to 50 of about 7,391,676 (191)

Organocatalytic synthesis and Anti-Trypanosomal activity evaluation of L-Pentofuranose-Mimetic iminosugars [PDF]

, 2022
Versión aceptada (Postprint)A series of L-lyxo and L-xylo- pentofuranose-mimetic iminosugars and derivatives were efficiently synthesized in a stereoselective manner, through a concise strategy which involves an organocatalyzed Mannich reaction of an ...

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Beta-carboline as a promising heterocyclic nucleus: Synthetic aspects, pharmacological potential and structure activity relationship

European Journal of Medicinal Chemistry Reports, 2022
Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic nucleus in the field of medicinal chemistry. It has different biological activities like antibacterial, anticancer, antifungal, antimalarial, antileishmanial, anti ...
Mahender Thatikayala, Pankaj Wadhwa, Paranjeet Kaur, Pankaj Kumar Singh, Ankit Yadav, Monika Kaushik, Sanjeev Kumar Sahu   +6 more
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Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants [PDF]

, 2009
The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua (Asteraceae), Pseudospondias microcarpa (Anacardiaceae ...
Brun, R., Swaleh, SAM, R Brun, Malebo, H.M., Ndiege, I. O., W Tanja, I.O Ndiege, Swaleh, S. A., Hassanali, A., Wenzler, T., Hassanali, A, Hamburger, M., M Cal, Ndiege, I.O, A Hassanali, U Séquin, Hamburger, M, Omolo, M. O., SAM Swaleh, Séquin, U, Malebo, H.M, Tanja, W., M Hamburger, Swaleh, S.A.M., Séquin, U., Cal, M., Omolo, M.O, Brun, R, Ndiege, I.O., Malebo, H. M., Cal, M, H.M Malebo, Omolo, M.O., M.O Omolo, Tanja, W, Swaleh, S. A. M.   +35 more
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Orally Active and Selective Tubulin Inhibitors as Anti-Trypanosome Agents

PLOS ONE, 2016
There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates for the treatment of this disease, which is based on the tubulin protein structural difference between mammalian ...
Vishal Nanavaty, Rati Lama, Ranjodh Sandhu, Bo Zhong, Daniel Kulman, Viharika Bobba, Anran Zhao, Bibo Li, Bin Su   +8 more
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Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity [PDF]

Bioorganic & Medicinal Chemistry Letters, 2009
A series of alkanediamide-linked bisbenzamidines was synthesized and tested in vitro against a drug-sensitive strain of Trypanosoma brucei brucei, a drug-resistant strain of Trypanosoma brucei rhodesiense and Pneumocystiscarinii. Bisbenzamidines linked with longer alkanediamide chains were potent inhibitors of both strains of T. brucei.
Huang, T.L., Vanden Eynde, Jean-Jacques, Mayence, A., Collins, M.S., Cushion, M.T., Rattendi, D., Londono, I., Mazumder, L., Bacchi, C.J., Yartlet, N.   +9 more
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Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. [PDF]

PLoS Neglected Tropical Diseases, 2018
Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the
Eva Doleželová, David Terán, Ondřej Gahura, Zuzana Kotrbová, Michaela Procházková, Dianne Keough, Petr Špaček, Dana Hocková, Luke Guddat, Alena Zíková   +9 more
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Anti-trypanosomal Phenolic Derivatives from

Natural Product Communications, 2014
Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a ...
Simone dos S. Grecco, Maria Júlia P. Félix, João Henrique G. Lago, Érika G. Pinto, André G. Tempone, Paulete Romoff, Marcelo José P. Ferreira, Patricia Sartorelli   +7 more
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Anti-trypanosomal activity of cysteine protease inhibitors.

, 2017
Anti-trypanosomal activity of cysteine protease inhibitors.
Andrei Leitão (769676), Sérgio de Albuquerque (769673), Juliana C. Gomes (1883650), Carlos A. Montanari (449507), Jean F. R. Ribeiro (769678), Mark Furber (2465680), Cristiana Gonçalez (769674), Peter W. Kenny (769675), Antonio C. B. Burtoloso (1776874), José Carlos Quilles Júnior (3769651), Josmar R. Rocha (449500)   +10 more
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Taxonomic identifiation, anti-trypanosomal activity, and metabolomics analyses of Mediterranean marine sponge associated actinomycetes

, 2015
Taxonomic identifiation, anti-trypanosomal activity, and metabolomics analyses of Mediterranean marine sponge associated ...
Horn, Hannes, Abdelmohsen, Usama Ramadan, Cheng Cheng (8013965), Cheng, Cheng, Polymenakou, Paraskevi, Paraskevi Polymenakou (8013974), Hentschel, Ute, RuAngelie Edrada-Ebel (8013977), Hannes Horn (8013971), Edrada-Ebel, RuAngelie, MacIntyre, Lynsey, Usama Ramadan Abdelmohsen (8013968), Ute Hentschel (8013980), Lynsey MacIntyre (800395)   +13 more
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Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a–7e, 8a–8e, and 9a–9e were designed and synthesised with the aim of evaluating their anti-bacterial and anti-trypanosomal activities and ...
Andrea Bistrović, Luka Krstulović, Ivana Stolić, Domagoj Drenjančević, Jasminka Talapko, Martin C. Taylor, John M. Kelly, Miroslav Bajić, Silvana Raić-Malić   +8 more
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