Results 61 to 70 of about 7,391,676 (191)

Bactericidal, Bacteriostatic, and Fungicidal Activities of Clausena anisata Fruit and Its Compounds, Stigmasteryl 3‐Palmitate (a Phytosterol Ester) and Phellopterin (a Furanocoumarin), Against Some Clinical Pathogens

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
C. anisata fruit extract and its compounds demonstrated potent broad‐spectrum antimicrobial activity, notably against Klebsiella pneumoniae (MIC 0.625 mg/mL; MLC 2.5 mg/mL) and Candida albicans (MIC 0.0781 mg/mL; MLC 0.625 mg/mL). The findings highlight promising bactericidal and fungicidal potential of stigmasteryl 3‐palmitate and phellopterin against
Emmanuel Kofi Kumatia, Alex Asase, Prince Kyei Baffour, Borge Leth Frimpong, Ernest Agyei, Nguyen Huu Tung   +5 more
wiley   +1 more source

Synthesis and Optimisation of P3 Substituted Vinyl Sulfone-Based Inhibitors as Anti-Trypanosomal Agents [PDF]

, 2020
A series of lysine-based vinyl sulfone peptidomimetics were synthesised and evaluated for anti-trypanosomal activity against bloodstream forms of T. brucei.
Knox, Andrew, Doherty, William, Evans, Paul, Adler, Nikoletta, Butler, Thomas J.   +4 more
core   +1 more source

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense

Molecules, 2017
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, “sleeping sickness”), we have investigated extracts from the leaves and bark of the West African Holarrhena ...
Charles Okeke Nnadi, Ngozi Justina Nwodo, Marcel Kaiser, Reto Brun, Thomas J. Schmidt   +4 more
doaj   +1 more source

Graphene quantum dots induce cascadic apoptosis via interaction with proteins associated with anti-oxidation after endocytosis by Trypanosoma brucei

Frontiers in Immunology, 2022
Trypanosoma brucei, the pathogen causing African sleeping sickness (trypanosomiasis) in humans, causes debilitating diseases in many regions of the world, but mainly in African countries with tropical and subtropical climates.
Yiwei Xie, Yiwei Xie, Yiwei Xie, Hongrui Liang, Hongrui Liang, Hongrui Liang, Ning Jiang, Ning Jiang, Ning Jiang, Dingyuan Liu, Dingyuan Liu, Dingyuan Liu, Naiwen Zhang, Naiwen Zhang, Naiwen Zhang, Qilong Li, Qilong Li, Qilong Li, Kai Zhang, Kai Zhang, Kai Zhang, Xiaoyu Sang, Xiaoyu Sang, Xiaoyu Sang, Ying Feng, Ying Feng, Ying Feng, Ran Chen, Ran Chen, Ran Chen, Yiwei Zhang, Yiwei Zhang, Yiwei Zhang, Qijun Chen, Qijun Chen, Qijun Chen   +35 more
doaj   +1 more source

CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei.
Georges C. Accrombessi, Jacques Poupaert, Raymond H. Fatondji, Salomé D. S. Kpoviessi, Fernand A. Gbaguidi, Bienvenu Glinma   +5 more
doaj  

Anti-trypanosomal Potential of Methanolic Extract of Calotropis gigantea Leaves against Trypanosma evansi and its Cytotoxicity

International Journal of Bio-Resource and Stress Management, 2023
In an attempt to find anti-trypanosomal extract/compound(s) from medicinal plant for the treatment of trypanosomosis, Calotropis gigantea leaves were extracted with methanol. The obtained extract was screened at concentrations (250-1000 μg ml-1) against 
P. Shaba, N. N. Pandey, O. P. Sharma, J. R. Rao, R. K. Singh   +4 more
doaj  

Crosspteryx fibrifuga leaf extract enhances host resistance to Trypanosoma congolense infection in mice by regulating host immune response and disrupting the activity of parasite superoxide dismutase enzyme

Frontiers in Microbiology, 2023
African trypanosomiasis, a neglected tropical disease, is caused by diverse species of the protozoan parasite belonging to the genus Trypanosoma. Although anti-trypanosomal medications exist, the increase in drug resistance and persistent antigenic ...
Nnamdi Ikeogu, Folayemi Olayinka-Adefemi, Chidalu Edechi, Chukwunonso Onyilagha, Ping Jia, Aaron Marshall, Julius Ode, Jude Uzonna   +7 more
doaj   +1 more source

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Nicoli Dias Oliveira, Mariana Cintra Pagotti, Lucas Antonio de Lima Paula, Mariana Zaramello Paixão, Daiane Albino dos Santos, Renata Faleiros de Freitas, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães   +9 more
wiley   +1 more source

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source

Reported anti-trypanosomal endoperoxides.

, 2012
Reported anti-trypanosomal endoperoxides.
Supchar Chokpaiboon (132469), James H. McKerrow (113918), Geraldine De Muylder (132472), Sean C. Nisam (132477), Roger G. Linington (132483), Khanitha Pudhom (132480), Gabriel Navarro (132468), Walter M. Bray (132474)   +7 more
core   +1 more source